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Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs

Aysis Koshy, Elodie Mathieux, François Stüder, Aude Bramoulle, Michele Lieb, Bruno Maria Colombo, Hinrich Gronemeyer, View ORCID ProfileMarco Antonio Mendoza-Parra  Correspondence email
Aysis Koshy
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Formal analysis, Investigation, Methodology
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Elodie Mathieux
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Formal analysis, Investigation, Methodology
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François Stüder
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Data curation, Software, Formal analysis
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Aude Bramoulle
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Resources, Methodology
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Michele Lieb
2Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
Roles: Resources, Methodology
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Bruno Maria Colombo
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Writing—review and editing
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Hinrich Gronemeyer
2Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
Roles: Supervision, Funding acquisition, Writing—review and editing
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Marco Antonio Mendoza-Parra
1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
Roles: Conceptualization, Formal analysis, Supervision, Funding acquisition, Writing—original draft
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  • ORCID record for Marco Antonio Mendoza-Parra
  • For correspondence: mmendoza{at}genoscope.cns.fr
Published 29 November 2022. DOI: 10.26508/lsa.202201627
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Article Information

vol. 6 no. 2 e202201627
DOI 
https://doi.org/10.26508/lsa.202201627
PubMed 
36446525

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received July 23, 2022
  • Revision received November 10, 2022
  • Accepted November 14, 2022
  • Published online November 29, 2022.

Copyright & Usage 
© 2022 Koshy et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Aysis Koshy1,*, Formal analysis, Investigation, Methodology,
  2. Elodie Mathieux1,*, Formal analysis, Investigation, Methodology,
  3. François Stüder1, Data curation, Software, Formal analysis,
  4. Aude Bramoulle1, Resources, Methodology,
  5. Michele Lieb2, Resources, Methodology,
  6. Bruno Maria Colombo1, Writing—review and editing,
  7. Hinrich Gronemeyer2, Supervision, Funding acquisition, Writing—review and editing and
  8. Marco Antonio Mendoza-Parra1, Conceptualization, Formal analysis, Supervision, Funding acquisition, Writing—original draft⇑
  1. 1UMR 8030 Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, University of Evry-val-d’Essonne, University Paris-Saclay, Évry, France
  2. 2Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
  1. Correspondence: mmendoza{at}genoscope.cns.fr
  1. ↵* Aysis Koshy and Elodie Mathieux contributed equally to this work

View Full Text

Funding

  • CEA, CNRS, and Université d’Evry-Val d’Essonne

  • Genopole Thematic Incentive Actions

    ATIGE-2017
    E Mathieux
  • Fondation pour la Recherche Medicale

    ALZ-201912009904
    A Koshy
  • Institut National du Cancer (INCa)

    2OI9-L22
    F Stüder
  • INCa

    2020-181
    A Bramoulle
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Combined RARβ and RARγ agonists lead to neuronal maturation
Aysis Koshy, Elodie Mathieux, François Stüder, Aude Bramoulle, Michele Lieb, Bruno Maria Colombo, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra
Life Science Alliance Nov 2022, 6 (2) e202201627; DOI: 10.26508/lsa.202201627

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Combined RARβ and RARγ agonists lead to neuronal maturation
Aysis Koshy, Elodie Mathieux, François Stüder, Aude Bramoulle, Michele Lieb, Bruno Maria Colombo, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra
Life Science Alliance Nov 2022, 6 (2) e202201627; DOI: 10.26508/lsa.202201627
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Volume 6, No. 2
February 2023
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