Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer

Paola Briseño-Díaz; Michael Schnoor; Martiniano Bello-Ramirez; Jose Correa-Basurto; Arturo Rojo-Domínguez; Leticia Arregui; Libia Vega; Enrique Núñez-González; Luis Andres Palau-Hernández; Carlos Guadalupe Parra-Torres; Óscar Manuel García Córdova; Ernesto Zepeda-Castilla; Eduardo Torices-Escalante; Leticia Domínguez-Camacho; Beatriz Xoconostle-Cazares; Marco Antonio Meraz-Ríos; Sandra Delfín-Azuara; Dayan Andrea Carrión-Estrada; Nicolas Villegas-Sepúlveda; Rosaura Hernández-Rivas; Maria del Rocio Thompson-Bonilla; Miguel Vargas

doi:10.26508/lsa.202302019

Research Article

Open Access

Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer

View ORCID ProfilePaola Briseño-Díaz, Michael Schnoor, Martiniano Bello-Ramirez, Jose Correa-Basurto, View ORCID ProfileArturo Rojo-Domínguez, View ORCID ProfileLeticia Arregui, View ORCID ProfileLibia Vega, Enrique Núñez-González, Luis Andres Palau-Hernández, Carlos Guadalupe Parra-Torres, View ORCID ProfileÓscar Manuel García Córdova, View ORCID ProfileErnesto Zepeda-Castilla, View ORCID ProfileEduardo Torices-Escalante, Leticia Domínguez-Camacho, Beatriz Xoconostle-Cazares, View ORCID ProfileMarco Antonio Meraz-Ríos, Sandra Delfín-Azuara, Dayan Andrea Carrión-Estrada, View ORCID ProfileNicolas Villegas-Sepúlveda, Rosaura Hernández-Rivas, Maria del Rocio Thompson-Bonilla, View ORCID ProfileMiguel Vargas Correspondence email

Paola Briseño-Díaz

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Formal analysis, Supervision

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Michael Schnoor

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Investigation, Writing—original draft

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Martiniano Bello-Ramirez

2Laboratory of Molecular Modeling and Drug Design of the Higher School of Medicine, National Polytechnic Institute, Mexico City, Mexico

Roles: Investigation

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Jose Correa-Basurto

2Laboratory of Molecular Modeling and Drug Design of the Higher School of Medicine, National Polytechnic Institute, Mexico City, Mexico

Roles: Investigation

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Arturo Rojo-Domínguez

3Department of Natural Sciences, Metropolitan Autonomous University, Mexico City, Mexico

Roles: Investigation

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Leticia Arregui

3Department of Natural Sciences, Metropolitan Autonomous University, Mexico City, Mexico

Roles: Investigation

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Libia Vega

4Toxicology Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico

Roles: Investigation

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Enrique Núñez-González

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Luis Andres Palau-Hernández

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Carlos Guadalupe Parra-Torres

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Óscar Manuel García Córdova

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Ernesto Zepeda-Castilla

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Eduardo Torices-Escalante

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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ORCID record for Eduardo Torices-Escalante

Leticia Domínguez-Camacho

5Department of Surgical Oncology and General Surgery, Hospital 1 de Octubre, ISSSTE, Mexico City, Mexico

Roles: Investigation

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Beatriz Xoconostle-Cazares

6Department of Biotechnology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Software, Investigation

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Marco Antonio Meraz-Ríos

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Investigation

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Sandra Delfín-Azuara

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Investigation

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Dayan Andrea Carrión-Estrada

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Supervision, Investigation

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Nicolas Villegas-Sepúlveda

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Investigation

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ORCID record for Nicolas Villegas-Sepúlveda

Rosaura Hernández-Rivas

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Investigation

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Maria del Rocio Thompson-Bonilla

7Biomedical and Transnational Research, Genomic Medicine Laboratory, Hospital 1 de Octubre, ISSSTE, México City, Mexico

Roles: Investigation

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Miguel Vargas

1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico

Roles: Conceptualization, Formal analysis, Supervision, Investigation, Writing—original draft

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ORCID record for Miguel Vargas
For correspondence: mavargas@cinvestav.mx

Published 9 October 2023. DOI: 10.26508/lsa.202302019

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KRas4B/PDE6 molecular antagonists

Paola Briseño-Díaz, Michael Schnoor, Martiniano Bello-Ramirez, Jose Correa-Basurto, Arturo Rojo-Domínguez, Leticia Arregui, Libia Vega, Enrique Núñez-González, Luis Andres Palau-Hernández, Carlos Guadalupe Parra-Torres, Óscar Manuel García Córdova, Ernesto Zepeda-Castilla, Eduardo Torices-Escalante, Leticia Domínguez-Camacho, Beatriz Xoconostle-Cazares, Marco Antonio Meraz-Ríos, Sandra Delfín-Azuara, Dayan Andrea Carrión-Estrada, Nicolas Villegas-Sepúlveda, Rosaura Hernández-Rivas, Maria del Rocio Thompson-Bonilla, Miguel Vargas

Life Science Alliance Oct 2023, 6 (12) e202302019; DOI: 10.26508/lsa.202302019

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KRas4B/PDE6 molecular antagonists

Life Science Alliance Oct 2023, 6 (12) e202302019; DOI: 10.26508/lsa.202302019

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