Research Article
Open Access
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Chiara E Geyer, View ORCID ProfileHung-Jen Chen, Alexander P Bye, Xue D Manz, View ORCID ProfileDenise Guerra, Tom G Caniels, Tom PL Bijl, Guillermo R Griffith, View ORCID ProfileWillianne Hoepel, Steven W de Taeye, View ORCID ProfileJennifer Veth, Alexander PJ Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, View ORCID ProfileJurjan Aman, Jonathan M Gibbins, View ORCID ProfileMarit J van Gils, View ORCID ProfileMenno PJ de Winther Correspondence email, View ORCID ProfileJeroen den Dunnen Correspondence email
Chiara E Geyer
1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft
Hung-Jen Chen
1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft
Alexander P Bye
2Institute for Cardiovascular and Metabolic Research, and School of Biological Sciences, University of Reading, Reading, UK
3Molecular and Clinical Sciences Research Institute, St George’s University, London, UK
4School of Pharmacy, University of Reading, Reading, UK
Roles: Resources, Investigation
Xue D Manz
5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Investigation
Denise Guerra
6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources
Tom G Caniels
6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources
Tom PL Bijl
6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources
Guillermo R Griffith
7Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam Institute for Infection and Immunity, Inflammatory Diseases, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Investigation
Willianne Hoepel
1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Investigation
Steven W de Taeye
6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources
Jennifer Veth
1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Investigation
Alexander PJ Vlaar
8Department of Intensive Care Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources
Gestur Vidarsson
9Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
10Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands
Roles: Resources, Writing—review and editing
Harm Jan Bogaard
5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Writing—review and editing
Jurjan Aman
5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Investigation
Jonathan M Gibbins
2Institute for Cardiovascular and Metabolic Research, and School of Biological Sciences, University of Reading, Reading, UK
Roles: Resources, Writing—review and editing
Marit J van Gils
6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Resources, Writing—review and editing
Menno PJ de Winther
7Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam Institute for Infection and Immunity, Inflammatory Diseases, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Conceptualization, Supervision, Funding acquisition, Methodology, Writing—review and editing
Jeroen den Dunnen
1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands
Roles: Conceptualization, Supervision, Funding acquisition, Methodology, Writing—review and editing
Published 12 September 2023. DOI: 10.26508/lsa.202302106
New drugs to counteract severe COVID-19 hyperinflammation
Chiara E Geyer, Hung-Jen Chen, Alexander P Bye, Xue D Manz, Denise Guerra, Tom G Caniels, Tom PL Bijl, Guillermo R Griffith, Willianne Hoepel, Steven W de Taeye, Jennifer Veth, Alexander PJ Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M Gibbins, Marit J van Gils, Menno PJ de Winther, Jeroen den Dunnen
Life Science Alliance Sep 2023, 6 (11) e202302106; DOI: 10.26508/lsa.202302106
New drugs to counteract severe COVID-19 hyperinflammation
Chiara E Geyer, Hung-Jen Chen, Alexander P Bye, Xue D Manz, Denise Guerra, Tom G Caniels, Tom PL Bijl, Guillermo R Griffith, Willianne Hoepel, Steven W de Taeye, Jennifer Veth, Alexander PJ Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M Gibbins, Marit J van Gils, Menno PJ de Winther, Jeroen den Dunnen
Life Science Alliance Sep 2023, 6 (11) e202302106; DOI: 10.26508/lsa.202302106
In this Issue
Volume 6, No. 11
November 2023
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