Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Chiara E Geyer; Hung-Jen Chen; Alexander P Bye; Xue D Manz; Denise Guerra; Tom G Caniels; Tom PL Bijl; Guillermo R Griffith; Willianne Hoepel; Steven W de Taeye; Jennifer Veth; Alexander PJ Vlaar; Amsterdam UMC COVID-19 Biobank; Gestur Vidarsson; Harm Jan Bogaard; Jurjan Aman; Jonathan M Gibbins; Marit J van Gils; Menno PJ de Winther; Jeroen den Dunnen

doi:10.26508/lsa.202302106

Research Article

Open Access

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Chiara E Geyer, View ORCID ProfileHung-Jen Chen, Alexander P Bye, Xue D Manz, View ORCID ProfileDenise Guerra, Tom G Caniels, Tom PL Bijl, Guillermo R Griffith, View ORCID ProfileWillianne Hoepel, Steven W de Taeye, View ORCID ProfileJennifer Veth, Alexander PJ Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, View ORCID ProfileJurjan Aman, Jonathan M Gibbins, View ORCID ProfileMarit J van Gils, View ORCID ProfileMenno PJ de Winther Correspondence email, View ORCID ProfileJeroen den Dunnen Correspondence email

Chiara E Geyer

1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft

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Hung-Jen Chen

1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft

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ORCID record for Hung-Jen Chen

Alexander P Bye

2Institute for Cardiovascular and Metabolic Research, and School of Biological Sciences, University of Reading, Reading, UK

3Molecular and Clinical Sciences Research Institute, St George’s University, London, UK

4School of Pharmacy, University of Reading, Reading, UK

Roles: Resources, Investigation

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Xue D Manz

5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Investigation

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Denise Guerra

6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources

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ORCID record for Denise Guerra

Tom G Caniels

6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources

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Tom PL Bijl

6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources

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Guillermo R Griffith

7Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam Institute for Infection and Immunity, Inflammatory Diseases, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Investigation

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Willianne Hoepel

1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Investigation

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ORCID record for Willianne Hoepel

Steven W de Taeye

6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources

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Jennifer Veth

1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Investigation

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ORCID record for Jennifer Veth

Alexander PJ Vlaar

8Department of Intensive Care Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources

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Gestur Vidarsson

9Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands

10Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands

Roles: Resources, Writing—review and editing

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Harm Jan Bogaard

5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Writing—review and editing

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Jurjan Aman

5Pulmonary Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Investigation

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Jonathan M Gibbins

2Institute for Cardiovascular and Metabolic Research, and School of Biological Sciences, University of Reading, Reading, UK

Roles: Resources, Writing—review and editing

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Marit J van Gils

6Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Resources, Writing—review and editing

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ORCID record for Marit J van Gils

Menno PJ de Winther

Roles: Conceptualization, Supervision, Funding acquisition, Methodology, Writing—review and editing

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ORCID record for Menno PJ de Winther
For correspondence: m.dewinther@amsterdamumc.nl

Jeroen den Dunnen

1Center for Experimental and Molecular Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, Netherlands

Roles: Conceptualization, Supervision, Funding acquisition, Methodology, Writing—review and editing

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ORCID record for Jeroen den Dunnen
For correspondence: j.dendunnen@amsterdamumc.nl

Published 12 September 2023. DOI: 10.26508/lsa.202302106

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New drugs to counteract severe COVID-19 hyperinflammation

Chiara E Geyer, Hung-Jen Chen, Alexander P Bye, Xue D Manz, Denise Guerra, Tom G Caniels, Tom PL Bijl, Guillermo R Griffith, Willianne Hoepel, Steven W de Taeye, Jennifer Veth, Alexander PJ Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M Gibbins, Marit J van Gils, Menno PJ de Winther, Jeroen den Dunnen

Life Science Alliance Sep 2023, 6 (11) e202302106; DOI: 10.26508/lsa.202302106

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New drugs to counteract severe COVID-19 hyperinflammation

Life Science Alliance Sep 2023, 6 (11) e202302106; DOI: 10.26508/lsa.202302106

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November 2023

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