Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses

Miaoran Xia; Bingbing Wang; Wujianan Sun; Dengyu Ji; Hang Zhou; Xuefeng Huang; Minghang Yu; Ziyang Su; Ping Chen; Kun Qu; Xi Wang

doi:10.26508/lsa.202302042

Research Article

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Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses

View ORCID ProfileMiaoran Xia, Bingbing Wang, Wujianan Sun, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, View ORCID ProfilePing Chen Correspondence email, View ORCID ProfileKun Qu Correspondence email, View ORCID ProfileXi Wang Correspondence email

Miaoran Xia

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

Roles: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing—original draft

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ORCID record for Miaoran Xia

Bingbing Wang

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

2Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

3Beijing Institute of Infectious Diseases, Beijing, China

4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5Department of Oncology, Capital Medical University, Beijing, China

Roles: Conceptualization, Data curation, Formal analysis, Visualization

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Wujianan Sun

6Department of Oncology, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

Roles: Software, Formal analysis, Visualization

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Dengyu Ji

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

Roles: Validation

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Hang Zhou

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

Roles: Investigation

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Xuefeng Huang

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

2Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

3Beijing Institute of Infectious Diseases, Beijing, China

4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5Department of Oncology, Capital Medical University, Beijing, China

Roles: Conceptualization, Validation

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Minghang Yu

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

2Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

3Beijing Institute of Infectious Diseases, Beijing, China

4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5Department of Oncology, Capital Medical University, Beijing, China

Roles: Conceptualization, Resources

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Ziyang Su

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

2Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

3Beijing Institute of Infectious Diseases, Beijing, China

4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5Department of Oncology, Capital Medical University, Beijing, China

Roles: Conceptualization

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Ping Chen

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

Roles: Conceptualization, Supervision, Funding acquisition, Methodology, Project administration, Writing—review and editing

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ORCID record for Ping Chen
For correspondence: chenping@ccmu.edu.cn

Kun Qu

6Department of Oncology, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

7Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China

Roles: Conceptualization, Data curation, Software, Supervision, Funding acquisition, Methodology, Writing—review and editing

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ORCID record for Kun Qu
For correspondence: qukun@ustc.edu.cn

Xi Wang

1Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China

2Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

3Beijing Institute of Infectious Diseases, Beijing, China

4National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China

5Department of Oncology, Capital Medical University, Beijing, China

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing

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ORCID record for Xi Wang
For correspondence: xiwang@ccmu.edu.cn

Published 10 July 2023. DOI: 10.26508/lsa.202302042

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Ablation of Lsd1 induces viral mimicry in thymocytes

Miaoran Xia, Bingbing Wang, Wujianan Sun, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, Ping Chen, Kun Qu, Xi Wang

Life Science Alliance Jul 2023, 6 (10) e202302042; DOI: 10.26508/lsa.202302042

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Ablation of Lsd1 induces viral mimicry in thymocytes

Miaoran Xia, Bingbing Wang, Wujianan Sun, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, Ping Chen, Kun Qu, Xi Wang

Life Science Alliance Jul 2023, 6 (10) e202302042; DOI: 10.26508/lsa.202302042

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