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Research Article
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Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme

Amy H Chan, Sabrina S Burgener, Kassandra Vezyrgiannis, Xiaohui Wang, Jadie Acklam, Jessica B Von Pein, Malvina Pizzuto, Larisa I Labzin, Dave Boucher, View ORCID ProfileKate Schroder  Correspondence email
Amy H Chan
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Methodology, Writing—original draft, Project administration, Writing—review and editing
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Sabrina S Burgener
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Formal analysis, Investigation, Methodology, Writing—review and editing
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Kassandra Vezyrgiannis
2Department of Biology, York Biomedical Research Institute, University of York, York, UK
Roles: Investigation
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Xiaohui Wang
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Formal analysis, Investigation
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Jadie Acklam
2Department of Biology, York Biomedical Research Institute, University of York, York, UK
Roles: Investigation
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Jessica B Von Pein
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Investigation
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Malvina Pizzuto
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
3Structure and Function of Biological Membranes Laboratory, Université Libre de Bruxelles, Brussels, Belgium
Roles: Formal analysis, Investigation, Methodology
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Larisa I Labzin
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Resources, Supervision, Writing—review and editing
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Dave Boucher
2Department of Biology, York Biomedical Research Institute, University of York, York, UK
Roles: Conceptualization, Resources, Supervision, Investigation, Methodology, Writing—review and editing
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Kate Schroder
1Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Methodology, Project administration, Writing—review and editing
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  • ORCID record for Kate Schroder
  • For correspondence: K.Schroder{at}imb.uq.edu.au
Published 9 August 2023. DOI: 10.26508/lsa.202301908
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Active caspase-4 is an interleukin-1β-converting enzyme
Amy H Chan, Sabrina S Burgener, Kassandra Vezyrgiannis, Xiaohui Wang, Jadie Acklam, Jessica B Von Pein, Malvina Pizzuto, Larisa I Labzin, Dave Boucher, Kate Schroder
Life Science Alliance Aug 2023, 6 (10) e202301908; DOI: 10.26508/lsa.202301908

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Active caspase-4 is an interleukin-1β-converting enzyme
Amy H Chan, Sabrina S Burgener, Kassandra Vezyrgiannis, Xiaohui Wang, Jadie Acklam, Jessica B Von Pein, Malvina Pizzuto, Larisa I Labzin, Dave Boucher, Kate Schroder
Life Science Alliance Aug 2023, 6 (10) e202301908; DOI: 10.26508/lsa.202301908
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Volume 6, No. 10
October 2023
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Subjects

  • Cell Biology
  • Immunology
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  • GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium
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