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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing

View ORCID ProfileSigny Chow, Olena Kis, View ORCID ProfileDavid T Mulder, Arnavaz Danesh, Jeff Bruce, Ting Ting Wang, Donna Reece, Nizar Bhalis, Paola Neri, View ORCID ProfilePeter JB Sabatini, View ORCID ProfileJonathan Keats, Suzanne Trudel  Correspondence email, View ORCID ProfileTrevor J Pugh  Correspondence email
Signy Chow
1University Health Network, Toronto, Canada
2Sunnybrook Health Sciences Centre, Toronto, Canada
3University of Toronto, Toronto, Canada
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Methodology
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  • ORCID record for Signy Chow
Olena Kis
1University Health Network, Toronto, Canada
Roles: Conceptualization, Data curation, Formal analysis, Investigation, Methodology
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David T Mulder
1University Health Network, Toronto, Canada
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Arnavaz Danesh
1University Health Network, Toronto, Canada
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Jeff Bruce
1University Health Network, Toronto, Canada
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Ting Ting Wang
1University Health Network, Toronto, Canada
3University of Toronto, Toronto, Canada
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Donna Reece
1University Health Network, Toronto, Canada
3University of Toronto, Toronto, Canada
Roles: Resources, Funding acquisition
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Nizar Bhalis
4University of Calgary, Calgary, Canada
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Paola Neri
4University of Calgary, Calgary, Canada
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Peter JB Sabatini
1University Health Network, Toronto, Canada
3University of Toronto, Toronto, Canada
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  • ORCID record for Peter JB Sabatini
Jonathan Keats
5Translational Genomics Research Institute, City of Hope, AZ, USA
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  • ORCID record for Jonathan Keats
Suzanne Trudel
1University Health Network, Toronto, Canada
3University of Toronto, Toronto, Canada
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  • For correspondence: trevor.pugh@utoronto.ca suzanne.trudel@uhn.ca
Trevor J Pugh
1University Health Network, Toronto, Canada
3University of Toronto, Toronto, Canada
6Ontario Institute for Cancer Research, Toronto, Canada
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Writing—review and editing
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  • For correspondence: trevor.pugh@utoronto.ca suzanne.trudel@uhn.ca
Published 3 November 2022. DOI: 10.26508/lsa.202201543
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Article Information

vol. 6 no. 1 e202201543
DOI 
https://doi.org/10.26508/lsa.202201543
PubMed 
36328595

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 31, 2022
  • Revision received September 29, 2022
  • Accepted September 30, 2022
  • Published online November 3, 2022.

Copyright & Usage 
© 2022 Chow et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Signy Chow1,2,3, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Methodology,
  2. Olena Kis1, Conceptualization, Data curation, Formal analysis, Investigation, Methodology,
  3. David T Mulder1, Conceptualization, Data curation, Investigation, Methodology,
  4. Arnavaz Danesh1, Formal analysis, Investigation,
  5. Jeff Bruce1, Formal analysis, Investigation,
  6. Ting Ting Wang1,3, Data curation, Methodology,
  7. Donna Reece1,3, Resources, Funding acquisition,
  8. Nizar Bhalis4, Resources, Investigation,
  9. Paola Neri4, Resources, Investigation,
  10. Peter JB Sabatini1,3, Resources, Investigation, Methodology,
  11. Jonathan Keats5, Conceptualization, Resources, Investigation,
  12. Suzanne Trudel1,3,*⇑, Conceptualization, Data curation, Supervision, Investigation, Methodology and
  13. Trevor J Pugh1,3,6,*, Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Writing—review and editing⇑
  1. 1University Health Network, Toronto, Canada
  2. 2Sunnybrook Health Sciences Centre, Toronto, Canada
  3. 3University of Toronto, Toronto, Canada
  4. 4University of Calgary, Calgary, Canada
  5. 5Translational Genomics Research Institute, City of Hope, AZ, USA
  6. 6Ontario Institute for Cancer Research, Toronto, Canada
  1. Correspondence: trevor.pugh{at}utoronto.ca; suzanne.trudel{at}uhn.ca
  1. ↵* Suzanne Trudel and Trevor J Pugh contributed equally to this work.

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Funding

  • Canadian Cancer Society

  • Princess Margaret Cancer Foundation

  • Princess Margaret Cancer Centre Innovation Accelerator Fund

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Target capture detection of V(D)J and IG translocation
Signy Chow, Olena Kis, David T Mulder, Arnavaz Danesh, Jeff Bruce, Ting Ting Wang, Donna Reece, Nizar Bhalis, Paola Neri, Peter JB Sabatini, Jonathan Keats, Suzanne Trudel, Trevor J Pugh
Life Science Alliance Nov 2022, 6 (1) e202201543; DOI: 10.26508/lsa.202201543

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Target capture detection of V(D)J and IG translocation
Signy Chow, Olena Kis, David T Mulder, Arnavaz Danesh, Jeff Bruce, Ting Ting Wang, Donna Reece, Nizar Bhalis, Paola Neri, Peter JB Sabatini, Jonathan Keats, Suzanne Trudel, Trevor J Pugh
Life Science Alliance Nov 2022, 6 (1) e202201543; DOI: 10.26508/lsa.202201543
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Volume 6, No. 1
January 2023
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