ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma

Roberto Ferrarese; Annalisa Izzo; Geoffroy Andrieux; Simon Lagies; Johanna Paulina Bartmuss; Anie Priscilla Masilamani; Alix Wasilenko; Daniela Osti; Stefania Faletti; Rana Schulzki; Shuai Yuan; Eva Kling; Valentino Ribecco; Dieter Henrik Heiland; Stefan Tholen; Marco Prinz; Giuliana Pelicci; Bernd Kammerer; Melanie Boerries; Maria Stella Carro

doi:10.26508/lsa.202201400

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ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma

View ORCID ProfileRoberto Ferrarese, Annalisa Izzo, Geoffroy Andrieux, View ORCID ProfileSimon Lagies, View ORCID ProfileJohanna Paulina Bartmuss, Anie Priscilla Masilamani, View ORCID ProfileAlix Wasilenko, Daniela Osti, View ORCID ProfileStefania Faletti, View ORCID ProfileRana Schulzki, Shuai Yuan, Eva Kling, View ORCID ProfileValentino Ribecco, Dieter Henrik Heiland, Stefan Tholen, Marco Prinz, Giuliana Pelicci, Bernd Kammerer, View ORCID ProfileMelanie Boerries, View ORCID ProfileMaria Stella Carro Correspondence email

Roberto Ferrarese

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: formal analysis, investigation, visualization, methodology, writing—original draft, review, and editing

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ORCID record for Roberto Ferrarese

Annalisa Izzo

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation, methodology, writing—original draft

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Geoffroy Andrieux

2Institute of Medical Bioinformatics and Systems Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

3German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany

Roles: formal analysis, visualization

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Simon Lagies

4Center for Biological Systems Analysis, University of Freiburg, Breisgau, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

6Faculty of Biology, University of Freiburg, Freiburg, Germany

Roles: formal analysis, visualization, methodology

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Johanna Paulina Bartmuss

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Anie Priscilla Masilamani

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Alix Wasilenko

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Daniela Osti

7Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy

Roles: resources

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Stefania Faletti

7Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy

Roles: resources

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ORCID record for Stefania Faletti

Rana Schulzki

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Shuai Yuan

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Eva Kling

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Valentino Ribecco

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: investigation

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Dieter Henrik Heiland

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

3German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany

Roles: formal analysis

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Stefan Tholen

8Institute of Clinical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Roles: formal analysis, methodology

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Marco Prinz

9Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

10Signaling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

11Center for NeuroModulation (NeuroModul), University of Freiburg, Freiburg, Germany

Roles: resources

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Giuliana Pelicci

7Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy

12Department of Translational Medicine, Piemonte Orientale University “Amedeo Avo-Gadro,” Novara, Italy

Roles: resources

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Bernd Kammerer

4Center for Biological Systems Analysis, University of Freiburg, Breisgau, Germany

5Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany

13BIOSS Centre of Biological Signaling Studies, University of Freiburg, Freiburg Germany

Roles: formal analysis, supervision

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Melanie Boerries

2Institute of Medical Bioinformatics and Systems Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

3German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany

Roles: formal analysis, supervision, funding acquisition

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ORCID record for Melanie Boerries

Maria Stella Carro

1Department of Neurosurgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisgau, Germany

Roles: conceptualization, supervision, funding acquisition, investigation, project administration, writing—original draft, review, and editing

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ORCID record for Maria Stella Carro
For correspondence: maria.carro{at}uniklinik-freiburg.de

Published 22 November 2022. DOI: 10.26508/lsa.202201400

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ZBTB18 inhibits SREBP-dependent lipid synthesis in GBM

Roberto Ferrarese, Annalisa Izzo, Geoffroy Andrieux, Simon Lagies, Johanna Paulina Bartmuss, Anie Priscilla Masilamani, Alix Wasilenko, Daniela Osti, Stefania Faletti, Rana Schulzki, Shuai Yuan, Eva Kling, Valentino Ribecco, Dieter Henrik Heiland, Stefan Tholen, Marco Prinz, Giuliana Pelicci, Bernd Kammerer, Melanie Boerries, Maria Stella Carro

Life Science Alliance Nov 2022, 6 (1) e202201400; DOI: 10.26508/lsa.202201400

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ZBTB18 inhibits SREBP-dependent lipid synthesis in GBM

Life Science Alliance Nov 2022, 6 (1) e202201400; DOI: 10.26508/lsa.202201400

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