OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

Elinor Hortle; Vi LT Tran; Kathryn Wright; Angela RM Fontaine; Natalia Pinello; Matthew B O’Rourke; Justin J-L Wong; Philip M Hansbro; Warwick J Britton; Stefan H Oehlers

doi:10.26508/lsa.202201476

Research Article

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OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

View ORCID ProfileElinor Hortle Correspondence email, Vi LT Tran, View ORCID ProfileKathryn Wright, View ORCID ProfileAngela RM Fontaine, View ORCID ProfileNatalia Pinello, Matthew B O’Rourke, View ORCID ProfileJustin J-L Wong, Philip M Hansbro, Warwick J Britton, View ORCID ProfileStefan H Oehlers Correspondence email

Elinor Hortle

1Tuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia

2The University of Sydney, Discipline of Infectious Diseases and Immunology and Sydney Institute for Infectious Diseases, Camperdown, Australia

3Centre for Inflammation and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia

Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Elinor Hortle
For correspondence: e.hortle@centenary.org.au stefan_oehlers@idlabs.a-star.edu.sg

Vi LT Tran

1Tuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia

Roles: Data curation, Formal analysis, Investigation

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Kathryn Wright

1Tuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia

Roles: Formal analysis, Validation, Investigation

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ORCID record for Kathryn Wright

Angela RM Fontaine

4Centenary Imaging and Sydney Cytometry at the Centenary Institute, The University of Sydney, Camperdown, Australia

Roles: Formal analysis, Visualization, Methodology

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ORCID record for Angela RM Fontaine

Natalia Pinello

5Epigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, Australia

6The University of Sydney, Faculty of Medicine and Health, Camperdown, Australia

Roles: Investigation, Methodology

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ORCID record for Natalia Pinello

Matthew B O’Rourke

3Centre for Inflammation and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia

Roles: Resources, Data curation, Software, Formal analysis, Investigation, Methodology

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Justin J-L Wong

5Epigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, Australia

6The University of Sydney, Faculty of Medicine and Health, Camperdown, Australia

Roles: Investigation, Methodology

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ORCID record for Justin J-L Wong

Philip M Hansbro

3Centre for Inflammation and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia

Roles: Resources

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Warwick J Britton

1Tuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia

7Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, Australia

Roles: Resources, Formal analysis, Supervision, Funding acquisition, Writing—review and editing

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Stefan H Oehlers

1Tuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia

2The University of Sydney, Discipline of Infectious Diseases and Immunology and Sydney Institute for Infectious Diseases, Camperdown, Australia

8A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Stefan H Oehlers
For correspondence: e.hortle@centenary.org.au stefan_oehlers@idlabs.a-star.edu.sg

Published 11 May 2022. DOI: 10.26508/lsa.202201476

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OXSR1 inhibits inflammasome activation

Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

Life Science Alliance May 2022, 5 (9) e202201476; DOI: 10.26508/lsa.202201476

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OXSR1 inhibits inflammasome activation

Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

Life Science Alliance May 2022, 5 (9) e202201476; DOI: 10.26508/lsa.202201476

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