C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

Paolo M Marchi; Lara Marrone; Laurent Brasseur; Audrey Coens; Christopher P Webster; Luc Bousset; Marco Destro; Emma F Smith; Christa G Walther; Victor Alfred; Raffaele Marroccella; Emily J Graves; Darren Robinson; Allan C Shaw; Lai Mei Wan; Andrew J Grierson; Stephen J Ebbens; Kurt J De Vos; Guillaume M Hautbergue; Laura Ferraiuolo; Ronald Melki; Mimoun Azzouz

doi:10.26508/lsa.202101276

Research Article

Open Access

C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

View ORCID ProfilePaolo M Marchi, View ORCID ProfileLara Marrone, Laurent Brasseur, Audrey Coens, View ORCID ProfileChristopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, View ORCID ProfileChrista G Walther, View ORCID ProfileVictor Alfred, Raffaele Marroccella, Emily J Graves, View ORCID ProfileDarren Robinson, View ORCID ProfileAllan C Shaw, Lai Mei Wan, Andrew J Grierson, View ORCID ProfileStephen J Ebbens, Kurt J De Vos, View ORCID ProfileGuillaume M Hautbergue, View ORCID ProfileLaura Ferraiuolo, View ORCID ProfileRonald Melki Correspondence email, View ORCID ProfileMimoun Azzouz Correspondence email

Paolo M Marchi

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Methodology, Writing—original draft

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Lara Marrone

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Validation, Investigation, Methodology, Writing—original draft, review, and editing

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Laurent Brasseur

2The French Alternative Energies and Atomic Energy Commission (CEA), Institut François Jacob (MIRcen) and The French National Centre for Scientific Research (CNRS), Laboratory of Neurodegenerative Diseases (UMR9199), Fontenay-aux-Roses, France

Roles: Resources, Methodology

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Audrey Coens

Roles: Methodology

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Christopher P Webster

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology, Writing—review and editing

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Luc Bousset

Roles: Resources, Methodology, Writing—review and editing

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Marco Destro

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources

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Emma F Smith

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

4Centre for Membrane Interactions and Dynamics, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Christa G Walther

5The Wolfson Light Microscopy Facility, University of Sheffield, Sheffield, UK

Roles: Software, Validation, Methodology

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ORCID record for Christa G Walther

Victor Alfred

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Raffaele Marroccella

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Emily J Graves

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Data curation, Formal analysis, Methodology

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Darren Robinson

5The Wolfson Light Microscopy Facility, University of Sheffield, Sheffield, UK

Roles: Resources, Data curation, Formal analysis, Methodology

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ORCID record for Darren Robinson

Allan C Shaw

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Lai Mei Wan

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Andrew J Grierson

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources

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Stephen J Ebbens

6Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK

Roles: Resources, Software, Methodology

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ORCID record for Stephen J Ebbens

Kurt J De Vos

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

4Centre for Membrane Interactions and Dynamics, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Methodology

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Guillaume M Hautbergue

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Conceptualization, Supervision, Writing—review and editing

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ORCID record for Guillaume M Hautbergue

Laura Ferraiuolo

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Resources, Supervision, Investigation, Methodology, Writing—review and editing

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Ronald Melki

Roles: Resources, Methodology, Writing—review and editing

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ORCID record for Ronald Melki
For correspondence: ronald.melki@cnrs.fr m.azzouz@sheffield.ac.uk

Mimoun Azzouz

1Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK

3Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, UK

Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing

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ORCID record for Mimoun Azzouz
For correspondence: ronald.melki@cnrs.fr m.azzouz@sheffield.ac.uk

Published 13 May 2022. DOI: 10.26508/lsa.202101276

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C9ORF72 DPRs spread from iAstrocytes to motor neurons

Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Emily J Graves, Darren Robinson, Allan C Shaw, Lai Mei Wan, Andrew J Grierson, Stephen J Ebbens, Kurt J De Vos, Guillaume M Hautbergue, Laura Ferraiuolo, Ronald Melki, Mimoun Azzouz

Life Science Alliance May 2022, 5 (9) e202101276; DOI: 10.26508/lsa.202101276

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C9ORF72 DPRs spread from iAstrocytes to motor neurons

Life Science Alliance May 2022, 5 (9) e202101276; DOI: 10.26508/lsa.202101276

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