DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

Nuria Gutierrez-Prat; Hedwig L Zuberer; Luca Mangano; Zahra Karimaddini; Luise Wolf; Stefka Tyanova; Lisa C Wellinger; Daniel Marbach; Vera Griesser; Piergiorgio Pettazzoni; James R Bischoff; Daniel Rohle; Chiara Palladino; Igor Vivanco

doi:10.26508/lsa.202101235

Research Article

Open Access

DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

View ORCID ProfileNuria Gutierrez-Prat, View ORCID ProfileHedwig L Zuberer, View ORCID ProfileLuca Mangano, View ORCID ProfileZahra Karimaddini, View ORCID ProfileLuise Wolf, View ORCID ProfileStefka Tyanova, View ORCID ProfileLisa C Wellinger, View ORCID ProfileDaniel Marbach, Vera Griesser, View ORCID ProfilePiergiorgio Pettazzoni, James R Bischoff, View ORCID ProfileDaniel Rohle, View ORCID ProfileChiara Palladino, View ORCID ProfileIgor Vivanco

Nuria Gutierrez-Prat

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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Hedwig L Zuberer

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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Luca Mangano

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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Zahra Karimaddini

2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland

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Luise Wolf

2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland

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Stefka Tyanova

2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland

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Lisa C Wellinger

4Ridgeline Discovery Basel, Basel, Switzerland

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Daniel Marbach

3Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland

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Vera Griesser

3Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland

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Piergiorgio Pettazzoni

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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James R Bischoff

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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Daniel Rohle

4Ridgeline Discovery Basel, Basel, Switzerland

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Chiara Palladino

1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland

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Igor Vivanco

5Institute of Pharmaceutical Science, King’s College London, London, UK

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Published 17 May 2022. DOI: 10.26508/lsa.202101235

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Citation Tools

DUSP4 restricts MAPK overdose in melanoma

Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

Life Science Alliance May 2022, 5 (9) e202101235; DOI: 10.26508/lsa.202101235