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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

View ORCID ProfileNuria Gutierrez-Prat, View ORCID ProfileHedwig L Zuberer, View ORCID ProfileLuca Mangano, View ORCID ProfileZahra Karimaddini, View ORCID ProfileLuise Wolf, View ORCID ProfileStefka Tyanova, View ORCID ProfileLisa C Wellinger, View ORCID ProfileDaniel Marbach, Vera Griesser, View ORCID ProfilePiergiorgio Pettazzoni, James R Bischoff, View ORCID ProfileDaniel Rohle, View ORCID ProfileChiara Palladino, View ORCID ProfileIgor Vivanco
Nuria Gutierrez-Prat
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Nuria Gutierrez-Prat
Hedwig L Zuberer
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Hedwig L Zuberer
Luca Mangano
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Luca Mangano
Zahra Karimaddini
2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Zahra Karimaddini
Luise Wolf
2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Luise Wolf
Stefka Tyanova
2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Stefka Tyanova
Lisa C Wellinger
4Ridgeline Discovery Basel, Basel, Switzerland
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  • ORCID record for Lisa C Wellinger
Daniel Marbach
3Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Daniel Marbach
Vera Griesser
3Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland
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Piergiorgio Pettazzoni
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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  • ORCID record for Piergiorgio Pettazzoni
James R Bischoff
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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Daniel Rohle
4Ridgeline Discovery Basel, Basel, Switzerland
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Chiara Palladino
1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
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Igor Vivanco
5Institute of Pharmaceutical Science, King’s College London, London, UK
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Published 17 May 2022. DOI: 10.26508/lsa.202101235
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Article Information

vol. 5 no. 9 e202101235
DOI 
https://doi.org/10.26508/lsa.202101235
PubMed 
35580987

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received September 16, 2021
  • Revision received May 4, 2022
  • Accepted May 5, 2022
  • Published online May 17, 2022.

Copyright & Usage 
© 2022 Gutierrez-Prat et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Nuria Gutierrez-Prat1,
  2. Hedwig L Zuberer1,
  3. Luca Mangano1,
  4. Zahra Karimaddini2,
  5. Luise Wolf2,
  6. Stefka Tyanova2,
  7. Lisa C Wellinger4,
  8. Daniel Marbach3,
  9. Vera Griesser3,
  10. Piergiorgio Pettazzoni1,
  11. James R Bischoff1,
  12. Daniel Rohle4,*⇑,
  13. Chiara Palladino1,*⇑ and
  14. Igor Vivanco5,*⇑
  1. 1Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Basel, Basel, Switzerland
  2. 2Roche Pharma Research and Early Development, Informatics, Roche Innovation Center Basel, Basel, Switzerland
  3. 3Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland
  4. 4Ridgeline Discovery Basel, Basel, Switzerland
  5. 5Institute of Pharmaceutical Science, King’s College London, London, UK
  1. Correspondence: igor.vivanco@kcl.ac.uk; chiara.palladino@roche.com; dan@charmtx.com
  1. ↵* Daniel Rohle, Chiara Palladino, and Igor Vivanco contributed equally to this work.

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Funding

  • Roche Postdoctoral Fellowship Program

    N Gutierrez-Prat
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DUSP4 restricts MAPK overdose in melanoma
Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco
Life Science Alliance May 2022, 5 (9) e202101235; DOI: 10.26508/lsa.202101235

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DUSP4 restricts MAPK overdose in melanoma
Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco
Life Science Alliance May 2022, 5 (9) e202101235; DOI: 10.26508/lsa.202101235
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Volume 5, No. 9
September 2022
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