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About the Cover

September 2022 | Volume 5, No. 9

Interviews

  • Rita Tewari: malaria parasite cell division
    Open Access
    Rita Tewari: malaria parasite cell division

    Rita Tewari

    Rita Tewari

    Published 1 September 2022

    Interview with Rita Tewari

Research Articles

  • Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy
    Open Access
    Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy

    Tiffany C Blair, Shelly Bambina, Gwen F Kramer, Alexa K Dowdell, Alejandro F Alice, Jason R Baird, Amanda W Lund, Brian D Piening, Marka R Crittenden, Michael J Gough

    Tiffany C Blair ... Michael J Gough

    Published 29 April 2022

    Radiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.

  • Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition
    Open Access
    Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition

    Margarida C Quaresma, Hugo M Botelho, Ines Pankonien, Cláudia S Rodrigues, Madalena C Pinto, Pau R Costa, Aires Duarte, Margarida D Amaral

    Margarida C Quaresma ... Margarida D Amaral

    Published 2 May 2022

    In this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.

  • miR-486 is essential for muscle function and suppresses a dystrophic transcriptome
    Open Access
    miR-486 is essential for muscle function and suppresses a dystrophic transcriptome

    Adrienne Samani, Rylie M Hightower, Andrea L Reid, Katherine G English, Michael A Lopez, J Scott Doyle, Michael J Conklin, David A Schneider, Marcas M Bamman, Jeffrey J Widrick, David K Crossman, Min Xie, David Jee, Eric C Lai, Matthew S Alexander

    Adrienne Samani ... Matthew S Alexander

    Published 5 May 2022

    The authors identify miR-486 as essential for normal muscle function and a driver of dystrophic transcriptomic pathways using mir-486 knockout mice and multiple sequencing platforms.

  • Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
    Open Access
    Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation

    Ke-Jun Han, Valeryia Mikalayeva, Scott A Gerber, Arminja N Kettenbach, Vytenis A Skeberdis, Rytis Prekeris

    Ke-Jun Han ... Rytis Prekeris

    Published 5 May 2022

    The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.

  • Genetic and compound screens uncover factors modulating cancer cell response to indisulam
    Open Access
    Genetic and compound screens uncover factors modulating cancer cell response to indisulam

    Ziva Pogacar, Kelvin Groot, Fleur Jochems, Matheus Dos Santos Dias, Antonio Mulero-Sánchez, Ben Morris, Mieke Roosen, Leyma Wardak, Giulia De Conti, Arno Velds, Cor Lieftink, Bram Thijssen, Roderick L Beijersbergen, René Bernards, Rodrigo Leite de Oliveira

    Ziva Pogacar ... Rodrigo Leite de Oliveira

    Published 9 May 2022

    The authors identify that loss of SRPK1 sensitises cancer cells to indisulam treatment and loss of CAND1 confers resistance. Resistance is mediated through RBM39. Furthermore, pharmacological Bcl-xL inhibition prevents acquired resistance to indisulam.

  • The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
    Open Access
    The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish

    Pauline Dao, Stefan Hajny, Ronald Mekis, Lukas Orel, Nora Dinhopl, Kristin Tessmar-Raible, Karin Nowikovsky

    Pauline Dao ... Karin Nowikovsky

    Published 13 June 2022

    The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.

  • Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
    Open Access
    Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection

    Anoop T Ambikan, Sara Svensson-Akusjärvi, Shuba Krishnan, Maike Sperk, Piotr Nowak, Jan Vesterbacka, Anders Sönnerborg, Rui Benfeitas, Ujjwal Neogi

    Anoop T Ambikan ... Ujjwal Neogi

    Published 10 May 2022

    A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.

  • <em>Plasmodium</em> SAS4: basal body component of male cell which is dispensable for parasite transmission
    Open Access
    Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission

    Mohammad Zeeshan, Declan Brady, Robert Markus, Sue Vaughan, David Ferguson, Anthony A Holder, Rita Tewari

    Mohammad Zeeshan ... Rita Tewari

    Published 12 May 2022

    This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.

  • OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
    Open Access
    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

    Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

    Elinor Hortle ... Stefan H Oehlers

    Published 11 May 2022

    Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.

  • Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
    Open Access
    Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response

    Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

    Shingo Kose ... Naoko Imamoto

    Published 17 May 2022

    Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

  • <em>C9ORF72</em>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
    Open Access
    C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

    Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Emily J Graves, Darren Robinson, Allan C Shaw, Lai Mei Wan, Andrew J Grierson, Stephen J Ebbens, Kurt J De Vos, Guillaume M Hautbergue, Laura Ferraiuolo, Ronald Melki, Mimoun Azzouz

    Paolo M Marchi ... Mimoun Azzouz

    Published 13 May 2022

    Extracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.

  • Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
    Open Access
    Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy

    Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

    Manon Garcia ... María Moriel-Carretero

    Published 13 May 2022

    We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access
    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access
    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • Expression regulation of genes is linked to their CpG density distributions around transcription start sites
    Open Access
    Expression regulation of genes is linked to their CpG density distributions around transcription start sites

    Hao Tian, Yueying He, Yue Xue, Yi Qin Gao

    Hao Tian ... Yi Qin Gao

    Published 17 May 2022

    In this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.

  • Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
    Open Access
    Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations

    Zixin Qin, Teng Huang, Maoni Guo, San Ming Wang

    Zixin Qin ... San Ming Wang

    Published 20 May 2022

    Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.

  • Comprehensive evolutionary analysis and nomenclature of plant G3BPs
    Open Access
    Comprehensive evolutionary analysis and nomenclature of plant G3BPs

    Aala A Abulfaraj, Hajime Ohyanagi, Kosuke Goto, Katsuhiko Mineta, Takashi Gojobori, Heribert Hirt, Naganand Rayapuram

    Aala A Abulfaraj ... Naganand Rayapuram

    Published 26 May 2022

    A thorough phylogenetic analysis of eukaryotic G3BPs (Rasputins) with a focus on plant G3BP proteins, classification into two subfamilies and a proposed systematic nomenclature.

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Volume 5, No. 9
September 2022
  • Table of Contents
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  • About the Cover
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