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Research Articles
- Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy
Radiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.
- Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition
In this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.
- miR-486 is essential for muscle function and suppresses a dystrophic transcriptome
The authors identify miR-486 as essential for normal muscle function and a driver of dystrophic transcriptomic pathways using mir-486 knockout mice and multiple sequencing platforms.
- Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.
- Genetic and compound screens uncover factors modulating cancer cell response to indisulam
The authors identify that loss of SRPK1 sensitises cancer cells to indisulam treatment and loss of CAND1 confers resistance. Resistance is mediated through RBM39. Furthermore, pharmacological Bcl-xL inhibition prevents acquired resistance to indisulam.
- The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.
- Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.
- Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission
This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.
- OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
- Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
- C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
Extracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.
- Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
- The HDL particle composition determines its antitumor activity in pancreatic cancer
The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
- DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
- Expression regulation of genes is linked to their CpG density distributions around transcription start sites
In this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.
- Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.
- Comprehensive evolutionary analysis and nomenclature of plant G3BPs
A thorough phylogenetic analysis of eukaryotic G3BPs (Rasputins) with a focus on plant G3BP proteins, classification into two subfamilies and a proposed systematic nomenclature.