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Research Article
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Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation

View ORCID ProfileMinas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, View ORCID ProfileTakuya Yamamoto, View ORCID ProfileHidetoshi Sakurai  Correspondence email
Minas Nalbandian
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
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  • ORCID record for Minas Nalbandian
Mingming Zhao
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
Roles: Investigation, Methodology, Writing—review and editing
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Hiroki Kato
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
2Asahi Kasei Co., Ltd., Tokyo, Japan
Roles: Conceptualization, Investigation, Methodology
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Tatsuya Jonouchi
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
Roles: Investigation, Methodology
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May Nakajima-Koyama
3Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
Roles: Investigation, Methodology
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Takuya Yamamoto
3Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
4Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
5Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan
Roles: Resources, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing
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  • ORCID record for Takuya Yamamoto
Hidetoshi Sakurai
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing
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  • For correspondence: hsakurai@cira.kyoto-u.ac.jp
Published 22 April 2022. DOI: 10.26508/lsa.202101312
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Article Information

vol. 5 no. 8 e202101312
DOI 
https://doi.org/10.26508/lsa.202101312
PubMed 
35459735

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received November 22, 2021
  • Revision received March 28, 2022
  • Accepted March 30, 2022
  • Published online April 22, 2022.

Copyright & Usage 
© 2022 Nalbandian et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Minas Nalbandian1⇑,
  2. Mingming Zhao, Investigation, Methodology, Writing—review and editing1,
  3. Hiroki Kato, Conceptualization, Investigation, Methodology1,2,
  4. Tatsuya Jonouchi, Investigation, Methodology1,
  5. May Nakajima-Koyama, Investigation, Methodology3,
  6. Takuya Yamamoto, Resources, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing3,4,5 and
  7. Hidetoshi Sakurai, Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing1⇑
  1. 1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
  2. 2Asahi Kasei Co., Ltd., Tokyo, Japan
  3. 3Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
  4. 4Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
  5. 5Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan
  1. Correspondence: hsakurai{at}cira.kyoto-u.ac.jp
  2. mnalband@stanford.edu
View Full Text

Funding

  • AMED-The Core Center for iPS Cell Research

    JP21bm0104001
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Heterogeneity in hiPSC-derived muscle progenitor cells
Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai
Life Science Alliance Apr 2022, 5 (8) e202101312; DOI: 10.26508/lsa.202101312

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Heterogeneity in hiPSC-derived muscle progenitor cells
Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai
Life Science Alliance Apr 2022, 5 (8) e202101312; DOI: 10.26508/lsa.202101312
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Volume 5, No. 8
August 2022
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