Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Table of Contents

August 2022 | Volume 5, No. 8

Research Articles

  • Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
    Open Access
    Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis

    Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabò, Andrea Bisso, Bruno Amati

    Nina Tanaskovic ... Bruno Amati

    Published 14 April 2022

    Max dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.

  • SMN-deficient cells exhibit increased ribosomal DNA damage
    Open Access
    SMN-deficient cells exhibit increased ribosomal DNA damage

    Evangelia Karyka, Nelly Berrueta Ramirez, Christopher P Webster, Paolo M Marchi, Emily J Graves, Vinay K Godena, Lara Marrone, Anushka Bhargava, Swagat Ray, Ke Ning, Hannah Crane, Guillaume M Hautbergue, Sherif F El-Khamisy, Mimoun Azzouz

    Evangelia Karyka ... Mimoun Azzouz

    Published 19 April 2022

    SMN deficiency leads to elevated ribosomal DNA damage that results in impaired ribosomal RNA synthesis and translation and is accompanied by a motor neuron-specific down-regulation of DDX21 protein.

  • Tricalbin proteins regulate plasma membrane phospholipid homeostasis
    Open Access
    Tricalbin proteins regulate plasma membrane phospholipid homeostasis

    Ffion B Thomas, Deike J Omnus, Jakob M Bader, Gary HC Chung, Nozomu Kono, Christopher J Stefan

    Ffion B Thomas ... Christopher J Stefan

    Published 19 April 2022

    The extended synaptotagmin (E-Syt) family are conserved proteins that function at membrane contacts. This study reveals that yeast E-Syt family members regulate phospholipid homeostasis necessary for plasma membrane integrity.

  • Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation
    Open Access
    Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation

    Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai

    Minas Nalbandian ... Hidetoshi Sakurai

    Published 22 April 2022

    This study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells.

  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
    Open Access
    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

    Lisa Merklinger ... J Preben Morth

    Published 22 April 2022

    This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.

  • The miR-26 family regulates early B cell development and transformation
    Open Access
    The miR-26 family regulates early B cell development and transformation

    Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog

    Katharina Hutter ... Sebastian Herzog

    Published 22 April 2022

    We show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.

  • The value of genotype-specific reference for transcriptome analyses in barley
    Open Access
    The value of genotype-specific reference for transcriptome analyses in barley

    Wenbin Guo, Max Coulter, Robbie Waugh, Runxuan Zhang

    Wenbin Guo ... Runxuan Zhang

    Published 22 April 2022

    We demonstrate in this study that using a common reference genome may lead to loss of genotype-specific information in the assembled Reference Transcript Dataset (RTD) and the generation of erroneous, incomplete, or misleading transcriptomics analysis results in barley.

  • Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice
    Open Access
    Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice

    Gang Li, Xin Li, Li Yang, Shuyue Wang, Yulin Dai, Baharan Fekry, Lucas Veillon, Lin Tan, Rebecca Berdeaux, Kristin Eckel-Mahan, Philip L Lorenzi, Zhongming Zhao, Richard Lehner, Kai Sun

    Gang Li ... Kai Sun

    Published 22 April 2022

    Ces1d is a crucial enzyme in adipose tissue. Here, we found a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce unique fatty acids which are key for glucose and lipid metabolism.

  • Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
    Open Access
    Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells

    Koji Kikuchi, Yasuhisa Sakamoto, Akiyoshi Uezu, Hideyuki Yamamoto, Kei-ichiro Ishiguro, Kenji Shimamura, Taro Saito, Shin-ichi Hisanaga, Hiroyuki Nakanishi

    Koji Kikuchi ... Hiroyuki Nakanishi

    Published 25 April 2022

    The microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth.

  • Nutrient sensitive protein <em>O</em>-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
    Open Access
    Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

    Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

    Shama Parween ... Suraiya A Ansari

    Published 25 April 2022

    Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.

  • Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption
    Open Access
    Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption

    Lin Lyu, Ru Feng, Mingnan Zhang, Xiaoqing Xie, Yinjing Liao, Yanjiao Zhou, Xiaokui Guo, Bing Su, Yair Dorsett, Lei Chen

    Lin Lyu ... Lei Chen

    Published 25 April 2022

    CORONATATOR, developed to analyze the subgenomic RNA of coronavirus, was applied on large number of sequencing data sets from coronaviruses, and shed light on viral gene regulation.

  • Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
    Open Access
    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

    Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt

    Anna Salerno-Kochan ... Sebastian Glatt

    Published 5 May 2022

    This study provides molecular insights into RNA target recognition by the TRIM-NHL protein Mei-P26 that functions in Drosophila ovarian germline stem cell maintenance, oogenesis, and spermatogenesis.

  • Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
    Open Access
    Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

    Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger

    Ali Hageb ... Hartmut Geiger

    Published 29 April 2022

    Analysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.

  • Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice
    Open Access
    Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

    Burak Bali, Eva Gruber-Dujardin, Kathrin Kusch, Vladan Rankovic, Tobias Moser

    Burak Bali ... Tobias Moser

    Published 5 May 2022

    This longitudinal study revealed stable expression of the fast-gating channelrhodopsin f-Chrimson in cochlear neurons of mice over at least 2 yr upon a single postnatal AAV dosing of the cochlea.

  • Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <em>Candida albicans</em>
    Open Access
    Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans

    Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika Borek, Leah E Cowen, Alexei Savchenko

    Peter J Stogios ... Alexei Savchenko

    Published 5 May 2022

    Structural characterization of shikimate pathway multi-enzyme Aro1 from opportunistic fungal pathogen Candida albicans provides the first molecular image of all five domains. Only four of these domains are active and individually essential for C. albicans viability.

Methods

  • Evaluation of the correctable decoding sequencing as a new powerful strategy for DNA sequencing
    Open Access
    Evaluation of the correctable decoding sequencing as a new powerful strategy for DNA sequencing

    Chu Cheng, Pengfeng Xiao

    Chu Cheng ... Pengfeng Xiao

    Published 14 April 2022

    This article proposed the correctable decoding sequencing technology with conservative theoretical error rate of 0.0009%, and evaluated its robustness by simulation. This technology can provide a powerful new protocol for NGS platforms, enabling accurate identification of rare mutations in medicine.

Resources

  • LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters
    Open Access
    LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

    Kamila Weissová, Bohumil Fafílek, Tomasz Radaszkiewicz, Canan Celiker, Petra Macháčková, Tamara Čechová, Jana Šebestíková, Aleš Hampl, Vítězslav Bryja, Pavel Krejčí, Tomáš Bárta

    Kamila Weissová ... Tomáš Bárta

    Published 19 April 2022

    Description of affordable ($40) open-source platform for real-time in-cell monitoring of luciferase activity.

  • Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
    Open Access
    Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis

    Jun Adachi, Akemi Kakudo, Yoko Takada, Junko Isoyama, Narumi Ikemoto, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Daigo Gunji, Yasuhiro Hara, Ryohei Katayama, Takeshi Tomonaga

    Jun Adachi ... Takeshi Tomonaga

    Published 4 May 2022

    Integrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.

Back to top
PreviousNext
Issue Cover

In this Issue

Volume 5, No. 8
August 2022
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Sign up for alerts

Jump to

  • Research Articles
  • Methods
  • Resources
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2023 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.