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Table of Contents

July 2022 | Volume 5, No. 7

Research Articles

  • SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape
    Open Access
    SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape

    Tarun Mishra, Rishikesh Dalavi, Garima Joshi, Atul Kumar, Pankaj Pandey, Sanjeev Shukla, Ram K Mishra, Ajit Chande

    Tarun Mishra ... Ajit Chande

    Published 16 March 2022

    This study underscores the significance of NTD-specific SARS-CoV-2 spike mutations E156G/Δ157-158 in determining virion infectivity and neutralization by vaccine-elicited antibodies.

  • Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo
    Open Access
    Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo

    Nikhila Krishnan, Maxx Swoger, Lindsay I Rathbun, Peter J Fioramonti, Judy Freshour, Michael Bates, Alison E Patteson, Heidi Hehnly

    Nikhila Krishnan ... Heidi Hehnly

    Published 18 March 2022

    Cell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.

  • Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies
    Open Access
    Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies

    Dominik P Buser, Gaétan Bader, Martin Spiess

    Dominik P Buser ... Martin Spiess

    Published 21 March 2022

    Nanobody toolkit enables the quantitative analysis of endosome-to-TGN transport of the mannose-6-phosphate receptor in cells depleted of retrograde transport machineries

  • All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal
    Open Access
    All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal

    Yuichiro Adachi, Masashi Masuda, Iori Sakakibara, Takayuki Uchida, Yuki Niida, Yuki Mori, Yuki Kamei, Yosuke Okumura, Hirokazu Ohminami, Kohta Ohnishi, Hisami Yamanaka-Okumura, Takeshi Nikawa, Yutaka Taketani

    Yuichiro Adachi ... Yutaka Taketani

    Published 22 March 2022

    ATRA increases GADD34 expression by decreasing the expression of Six1, which down-regulates the transcriptional activity with TLE3 and increasing mRNA stability through blocking the interaction between TTP and ARE on GADD34 mRNA, resulting in muscle fiber type change.

  • Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
    Open Access
    Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly

    Haruka Matsumori, Kenji Watanabe, Hiroaki Tachiwana, Tomoko Fujita, Yuma Ito, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroko Osakada, Tokuko Haraguchi, Akinori Awazu, Hiroshi Ochiai, Yuka Sakata, Koji Ochiai, Tsutomu Toki, Etsuro Ito, Ilya G Goldberg, Kazuaki Tokunaga, Mitsuyoshi Nakao, Noriko Saitoh

    Haruka Matsumori ... Noriko Saitoh

    Published 23 March 2022

    High content image analysis, single molecule tracking, modeling, and DBA patient analysis revealed that ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.

  • Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans
    Open Access
    Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans

    Yihang Zhou, Yi Wang, Xiao Xiong, Arthur G Appel, Chao Zhang, Xu Wang

    Yihang Zhou ... Xu Wang

    Published 1 April 2022

    A bioinformatic pipeline for telomeric repeat motif detection was applied to 129 insect species and identified diverse forms of telomeric motifs in Hymenopterans, including canonical 5-bp, novel 8- and 9-bp forms, suggesting extraordinary evolutionary fluidity of telomeric repeat in Hymenopterans.

  • TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
    Open Access
    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis

    Audrey Laurent, Thierry Madigou, Maud Bizot, Marion Turpin, Gaëlle Palierne, Elise Mahé, Sarah Guimard, Raphaël Métivier, Stéphane Avner, Christine Le Péron, Gilles Salbert

    Audrey Laurent ... Gilles Salbert

    Published 29 March 2022

    TET2-mediated oxidation of 5-methylcytosine establishes an antiviral state and contributes to MYC-dependent down-regulation of genes involved in lysosome biogenesis and function in breast cancer cells.

  • Quantitative analysis of nuclear pore complex organization in <em>Schizosaccharomyces pombe</em>
    Open Access
    Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

    Joseph M Varberg, Jay R Unruh, Andrew J Bestul, Azqa A Khan, Sue L Jaspersen

    Joseph M Varberg ... Sue L Jaspersen

    Published 30 March 2022

    Characterization of nuclear pores in Schizosaccharomyces pombe identifies regions of heterogeneous NPC density and composition and shows that NPCs are excluded near the spindle pole body by Lem2-mediated centromere tethering.

  • ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
    Open Access
    ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

    Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska

    Marta Wróbel ... Marta Miączyńska

    Published 30 March 2022

    ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.

  • Functional and structural deficiencies of Gemin5 variants associated with neurological disorders
    Open Access
    Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

    Rosario Francisco-Velilla, Azman Embarc-Buh, Francisco del Caño-Ochoa, Salvador Abellan, Marçal Vilar, Sara Alvarez, Alberto Fernandez-Jaen, Sukhleen Kour, Deepa S Rajan, Udai Bhan Pandey, Santiago Ramón-Maiques, Encarnacion Martinez-Salas

    Rosario Francisco-Velilla ... Encarnacion Martinez-Salas

    Published 7 April 2022

    Gemin5 clinical variants perturbing the dimerization module and the noncanonical RNA-binding site impair oligomerization, RNA–protein interaction networks, ribosome association, and protein stability.

  • The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity
    Open Access
    The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

    Helena Dragic, Audrey Barthelaix, Cédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Serge N Manié

    Helena Dragic ... Serge N Manié

    Published 8 April 2022

    We present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.

  • A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway
    Open Access
    A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway

    Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

    Li Zhong ... Andrea Cimarelli

    Published 8 April 2022

    In this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.

  • Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core
    Open Access
    Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core

    Abdoallah Sharaf, Mallika Vijayanathan, Miroslav Oborník, Iva Mozgová

    Abdoallah Sharaf ... Iva Mozgová

    Published 19 April 2022

    This study strengthens the support for PRC2 emergence before the diversification of eukaryotes, detects a common presence of E(z) and ESC, indicating a conserved core, identifies diverse VEFS-Box Su(z)12 candidate proteins, and proposes a substrate specificity shift during E(z) evolution.

Methods

  • Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics
    Open Access
    Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics

    Felix Schmieder, Rouhollah Habibey, Johannes Striebel, Lars Büttner, Jürgen Czarske, Volker Busskamp

    Felix Schmieder ... Volker Busskamp

    Published 13 April 2022

    Holographic optogenetic stimulation of human iPSC–derived neuronal networks was exploited to map precise functional connectivity motifs and their long-term dynamics during network development.

Resources

  • Intensive single-cell analysis reveals immune-cell diversity among healthy individuals
    Open Access
    Intensive single-cell analysis reveals immune-cell diversity among healthy individuals

    Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata-Yanagimoto, Yumiko Imai, Kaori Nakayama-Hosoya, Ai Kawana-Tachikawa, Taketoshi Mizutani, Yutaka Suzuki

    Yukie Kashima ... Yutaka Suzuki

    Published 5 April 2022

    This study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.

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Volume 5, No. 7
July 2022
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