Table of Contents
Research Articles
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escapeThis study underscores the significance of NTD-specific SARS-CoV-2 spike mutations E156G/Δ157-158 in determining virion infectivity and neutralization by vaccine-elicited antibodies.
Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivoCell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.
Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodiesNanobody toolkit enables the quantitative analysis of endosome-to-TGN transport of the mannose-6-phosphate receptor in cells depleted of retrograde transport machineries
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signalATRA increases GADD34 expression by decreasing the expression of Six1, which down-regulates the transcriptional activity with TLE3 and increasing mRNA stability through blocking the interaction between TTP and ARE on GADD34 mRNA, resulting in muscle fiber type change.
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assemblyHigh content image analysis, single molecule tracking, modeling, and DBA patient analysis revealed that ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.
Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in HymenopteransA bioinformatic pipeline for telomeric repeat motif detection was applied to 129 insect species and identified diverse forms of telomeric motifs in Hymenopterans, including canonical 5-bp, novel 8- and 9-bp forms, suggesting extraordinary evolutionary fluidity of telomeric repeat in Hymenopterans.
TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesisTET2-mediated oxidation of 5-methylcytosine establishes an antiviral state and contributes to MYC-dependent down-regulation of genes involved in lysosome biogenesis and function in breast cancer cells.
Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombeCharacterization of nuclear pores in Schizosaccharomyces pombe identifies regions of heterogeneous NPC density and composition and shows that NPCs are excluded near the spindle pole body by Lem2-mediated centromere tethering.
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathwayESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.
Functional and structural deficiencies of Gemin5 variants associated with neurological disordersGemin5 clinical variants perturbing the dimerization module and the noncanonical RNA-binding site impair oligomerization, RNA–protein interaction networks, ribosome association, and protein stability.
The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcityWe present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.
A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathwayIn this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.
Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional coreThis study strengthens the support for PRC2 emergence before the diversification of eukaryotes, detects a common presence of E(z) and ESC, indicating a conserved core, identifies diverse VEFS-Box Su(z)12 candidate proteins, and proposes a substrate specificity shift during E(z) evolution.
Resources
Intensive single-cell analysis reveals immune-cell diversity among healthy individualsThis study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.
Methods
Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogeneticsHolographic optogenetic stimulation of human iPSC–derived neuronal networks was exploited to map precise functional connectivity motifs and their long-term dynamics during network development.
