Research Article
Open Access
DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins
Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, View ORCID ProfileFelix Lansing, Jovan Mircetic, Mirko Theis, View ORCID ProfileFrank Buchholz Correspondence email
Li Ding
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Conceptualization, Data curation, Investigation, Methodology, Writing—original draft
Lukas Theo Schmitt
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Data curation, Investigation
Melanie Brux
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
2National Center for Tumor Diseases (NCT/UCC) Dresden, German Cancer Research Center (DKFZ), University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
Roles: Investigation
Duran Sürün
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Investigation
Martina Augsburg
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Investigation
Felix Lansing
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Investigation
Jovan Mircetic
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
3Mildred Scheel Early Career Center, National Center for Tumor Diseases Dresden (NCT/UCC), Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
Roles: Investigation
Mirko Theis
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
2National Center for Tumor Diseases (NCT/UCC) Dresden, German Cancer Research Center (DKFZ), University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
Roles: Validation, Investigation, Methodology
Frank Buchholz
1Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
2National Center for Tumor Diseases (NCT/UCC) Dresden, German Cancer Research Center (DKFZ), University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
4German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK) Partner Site Dresden, Dresden, Germany
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing
Published 14 March 2022. DOI: 10.26508/lsa.202101321
dCas9-KRABd-MeCP2 induce long-term epigenetic gene silencing
Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, Felix Lansing, Jovan Mircetic, Mirko Theis, Frank Buchholz
Life Science Alliance Mar 2022, 5 (6) e202101321; DOI: 10.26508/lsa.202101321
In this Issue
Volume 5, No. 6
June 2022
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