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Table of Contents

June 2022 | Volume 5, No. 6

Interviews

  • Umut Şahin: SUMOylation in health and disease
    Open Access
    Umut Şahin: SUMOylation in health and disease

    Umut Şahin

    Umut Şahin

    Published 3 June 2022

    Umut Şahin is an Associate Professor in the Department of Molecular Biology and Genetics at Boğaziçi University’s Center for Life Sciences and Technologies. We asked him about his recent paper published in Life Science Alliance (LSA) and his experience in science thus far.

Research Articles

  • mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients
    Open Access
    mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

    Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

    Elena Azzolini ... Maria Rescigno

    Published 15 February 2022

    Immunocompromised patients poorly respond to two doses of SARS-CoV-2 mRNA vaccines. However, an additional booster dose elicits a strong humoral and cellular immune response in these subjects.

  • Human immunodeficiency virus type 1 impairs sumoylation
    Open Access
    Human immunodeficiency virus type 1 impairs sumoylation

    Bilgül Mete, Emre Pekbilir, Bilge Nur Bilge, Panagiota Georgiadou, Elif Çelik, Tolga Sutlu, Fehmi Tabak, Umut Sahin

    Bilgül Mete ... Umut Sahin

    Published 18 February 2022

    The HIV type 1 dampens host cell sumoylation in vitro and reduces the expression of UBA2 protein, a subunit of the SUMO E1–activating enzyme. In vivo, infection in patients is associated with diminished global leukocyte sumoylation activity.

  • pSATdb: a database of mitochondrial common, polymorphic, and unique microsatellites
    Open Access
    pSATdb: a database of mitochondrial common, polymorphic, and unique microsatellites

    Sonu Kumar, Ashutosh Singh, Asheesh Shanker

    Sonu Kumar ... Asheesh Shanker

    Published 18 February 2022

    The polymorphic microSATellites database (pSATdb) provides information on common, polymorphic, and unique mitochondrial microsatellites.

  • Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation
    Open Access
    Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation

    Satarupa Ganguly, Bartika Ghoshal, Ishani Banerji, Shreya Bhattacharjee, Sreemoyee Chakraborty, Avijit Goswami, Kamalika Mukherjee, Suvendra N Bhattacharyya

    Satarupa Ganguly ... Suvendra N Bhattacharyya

    Published 24 February 2022

    Leishmania donovani infects and hijacks microRNA import-export machinery of host macrophages and survives by communicating the host-derived miR-146a to neighbouring cells and stops inflammation.

  • Genome analysis of <em>Legionella pneumophila</em> ST23 from various countries reveals highly similar strains
    Open Access
    Genome analysis of Legionella pneumophila ST23 from various countries reveals highly similar strains

    Maria Luisa Ricci, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Christophe Ginevra, Sophie Jarraud, Antonietta Girolamo, Fabrizio Barbanti, Maria Cristina Rota, Diane Lindsay, Jamie Gorzynski, Søren A Uldum, Sharmin Baig, Marina Foti, Giancarlo Petralito, Stefania Torri, Marino Faccini, Maira Bonini, Gabriella Gentili, Sabrina Senatore, Anna Lamberti, Joao André Carrico, Maria Scaturro

    Maria Luisa Ricci ... Maria Scaturro

    Published 2 March 2022

    ST23 isolated in Italy are analysed by cgMLST and SNP approaches and they are also compared with ST23 from other countries. They are found to be phylogenetically related independently on year, town, or country of isolation.

  • Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade
    Open Access
    Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

    Yuki Miyai, Daisuke Sugiyama, Tetsunari Hase, Naoya Asai, Tetsuro Taki, Kazuki Nishida, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa, Hiroki Kobayashi, Shinji Mii, Yukihiro Shiraki, Yoshinori Hasegawa, Hiroyoshi Nishikawa, Yuichi Ando, Masahide Takahashi, Atsushi Enomoto

    Yuki Miyai ... Atsushi Enomoto

    Published 2 March 2022

    Meflin/ISLR is the marker of a cancer-associated fibroblast subset that enhances tumor response to immune checkpoint blockade therapy.

  • AGO1 regulates pericentromeric regions in mouse embryonic stem cells
    Open Access
    AGO1 regulates pericentromeric regions in mouse embryonic stem cells

    Madlen Müller, Tara Fäh, Moritz Schaefer, Victoria Hermes, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo

    Madlen Müller ... Constance Ciaudo

    Published 2 March 2022

    Depletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.

  • LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity
    Open Access
    LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity

    Giuseppe Bombaci, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Eric Chi-Wang Yu, Gillian M Mackie, Matthew Pugh, Vedat Burak Ozan, Yara Banz, Thibaud Spinetti, Cedric Hirzel, Esther Youd, Joerg C Schefold, Graham Taylor, Amiq Gazdhar, Nicolas Bonadies, Anne Angelillo-Scherrer, Pascal Schneider, Kendle M Maslowski, Ramanjaneyulu Allam

    Giuseppe Bombaci ... Ramanjaneyulu Allam

    Published 7 March 2022

    RNH1 prevents inflammation by inhibiting inflammasome activation through controlling caspase-1 protein levels. In COVID-19 patients, RNH1 expression levels were negatively associated with disease severity and inflammation, suggesting a role for RNH1 in SARS-CoV-2–mediated inflammation and pathology.

  • Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern
    Open Access
    Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern

    Taishi Kondo, Kazuhiro Matsuoka, Shun Umemoto, Tomoshige Fujino, Gosuke Hayashi, Yasumasa Iwatani, Hiroshi Murakami

    Taishi Kondo ... Hiroshi Murakami

    Published 7 March 2022

    By extensive affinity maturation against the SARS-CoV-2 spike protein, we developed a monobody with potent neutralizing activity against SARS-CoV-2 B.1.1 and four other variants of concern.

  • Transcellular blood–brain barrier disruption in malaria-induced reversible brain edema
    Open Access
    Transcellular blood–brain barrier disruption in malaria-induced reversible brain edema

    Jessica Jin, Mame Aida Ba, Chi Ho Wai, Sanjib Mohanty, Praveen K Sahu, Rajyabardhan Pattnaik, Lukas Pirpamer, Manuel Fischer, Sabine Heiland, Michael Lanzer, Friedrich Frischknecht, Ann-Kristin Mueller, Johannes Pfeil, Megharay Majhi, Marek Cyrklaff, Samuel C Wassmer, Martin Bendszus, Angelika Hoffmann

    Jessica Jin ... Angelika Hoffmann

    Published 8 March 2022

    We present how reversible edema can reliably be induced in experimental cerebral malaria and show that it is associated with transcellular blood–brain barrier disruption and delayed microhemorrhages.

  • Conserved exchange of paralog proteins during neuronal differentiation
    Open Access
    Conserved exchange of paralog proteins during neuronal differentiation

    Domenico Di Fraia, Mihaela Anitei, Marie-Therese Mackmull, Luca Parca, Laura Behrendt, Amparo Andres-Pons, Darren Gilmour, Manuela Helmer Citterich, Christoph Kaether, Martin Beck, Alessandro Ori‬‬

    Domenico Di Fraia ... Alessandro Ori‬‬

    Published 10 March 2022

    Paralog proteins promote fine tuning of protein complexes. The author identified a specific paralog signature conserved across vertebrate neuronal differentiation. Altering the ratio of SEC23 paralogs in the COPII complex influences neuronal differentiation in a opposite way.

  • Septins tune lipid kinase activity and PI(4,5)P<sub>2</sub> turnover during G-protein–coupled PLC signalling in vivo
    Open Access
    Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein–coupled PLC signalling in vivo

    Aastha Kumari, Avishek Ghosh, Sourav Kolay, Padinjat Raghu

    Aastha Kumari ... Padinjat Raghu

    Published 11 March 2022

    In Drosophila photoreceptors, PI(4,5)P2 synthesis during PLC signalling is regulated by PIP5K and septins.

  • Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt
    Open Access
    Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt

    Brittany L Dunkerly-Eyring, Shi Pan, Miguel Pinilla-Vera, Desirae McKoy, Sumita Mishra, Maria I Grajeda Martinez, Christian U Oeing, Mark J Ranek, David A Kass

    Brittany L Dunkerly-Eyring ... David A Kass

    Published 14 March 2022

    Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation.

  • DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins
    Open Access
    DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

    Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, Felix Lansing, Jovan Mircetic, Mirko Theis, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 14 March 2022

    Long-term epigenetic gene silencing can be induced independently of DNA methylation by dCas9-KRABd-MeCP2 fusion proteins.

  • Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress
    Open Access
    Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress

    Yoshitami Hashimoto, Hirofumi Tanaka

    Yoshitami Hashimoto ... Hirofumi Tanaka

    Published 15 March 2022

    Mre11 exonuclease facilitates the processing of stalled replication forks upon mitotic entry, leading to irreversible mitotic progression and mitotic replisome disassembly.

  • Structure and conformational dynamics of <em>Clostridioides difficile</em> toxin A
    Open Access
    Structure and conformational dynamics of Clostridioides difficile toxin A

    Baohua Chen, Sujit Basak, Peng Chen, Changcheng Zhang, Kay Perry, Songhai Tian, Clinton Yu, Min Dong, Lan Huang, Mark E Bowen, Rongsheng Jin

    Baohua Chen ... Rongsheng Jin

    Published 15 March 2022

    This study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication.

  • Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma
    Open Access
    Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma

    Charles Capdeville, Linda Russo, David Penton, Jessica Migliavacca, Milica Zecevic, Alexandre Gries, Stephan CF Neuhauss, Michael A Grotzer, Martin Baumgartner

    Charles Capdeville ... Martin Baumgartner

    Published 16 March 2022

    Spatial proteomics identifies MAP4K4 as a regulator of the plasma membrane-associated proteome and reveals CD155 and EndoA1 as mediators of proliferation and invasiveness in medulloblastoma cells.

  • LINE-1 and SINE-B1 mapping and genome diversification in <em>Proechimys</em> species (Rodentia: Echimyidae)
    Open Access
    LINE-1 and SINE-B1 mapping and genome diversification in Proechimys species (Rodentia: Echimyidae)

    Simone Cardoso Soares, Eduardo Schmidt Eler, Carlos Eduardo Faresin e Silva, Maria Nazareth Ferreira da Silva, Naiara Pereira Araújo, Marta Svartman, Eliana Feldberg

    Simone Cardoso Soares ... Eliana Feldberg

    Published 18 March 2022

    Signal distribution of L1 and B1 among chromosomes in five species of Proechimys may represent a strong indication of their role in karyotype diversity of this speciose Neotropical rodent.

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Volume 5, No. 6
June 2022
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