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Angioplasty induces epigenomic remodeling in injured arteries

Mengxue Zhang, Go Urabe, Hatice Gulcin Ozer, Xiujie Xie, Amy Webb, Takuro Shirasu, Jing Li, Renzhi Han, K Craig Kent, View ORCID ProfileBowen Wang  Correspondence email, View ORCID ProfileLian-Wang Guo  Correspondence email
Mengxue Zhang
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Data curation, Investigation
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Go Urabe
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Data curation, Formal analysis
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Hatice Gulcin Ozer
2Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA
Roles: Formal analysis, Investigation, Visualization
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Xiujie Xie
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Data curation, Methodology
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Amy Webb
2Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA
Roles: Formal analysis, Investigation, Visualization
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Takuro Shirasu
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Data curation
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Jing Li
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Data curation
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Renzhi Han
3Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA
Roles: Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Gene editing methodology
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K Craig Kent
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Supervision, Funding acquisition
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Bowen Wang
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
Roles: Conceptualization, Formal analysis, Investigation, Writing—review and editing
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  • ORCID record for Bowen Wang
  • For correspondence: bw2pw@virginia.edu
Lian-Wang Guo
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
4Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, VA, USA
5Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Lian-Wang Guo
  • For correspondence: lg8zr@virginia.edu
Published 15 February 2022. DOI: 10.26508/lsa.202101114
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Article Information

vol. 5 no. 5 e202101114
DOI 
https://doi.org/10.26508/lsa.202101114
PubMed 
35169042

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 5, 2021
  • Revision received January 25, 2022
  • Accepted January 26, 2022
  • Published online February 15, 2022.

Copyright & Usage 
© 2022 Zhang et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Mengxue Zhang, Data curation, Investigation1,*,
  2. Go Urabe, Data curation, Formal analysis1,*,
  3. Hatice Gulcin Ozer, Formal analysis, Investigation, Visualization2,
  4. Xiujie Xie, Data curation, Methodology1,
  5. Amy Webb, Formal analysis, Investigation, Visualization2,
  6. Takuro Shirasu, Data curation1,
  7. Jing Li, Data curation1,
  8. Renzhi Han, Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Gene editing methodology3,
  9. K Craig Kent, Supervision, Funding acquisition1,
  10. Bowen Wang, Conceptualization, Formal analysis, Investigation, Writing—review and editing1⇑ and
  11. Lian-Wang Guo, Conceptualization, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing1,4,5⇑
  1. 1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, USA
  2. 2Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA
  3. 3Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA
  4. 4Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville, VA, USA
  5. 5Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
  1. Correspondence: lg8zr{at}virginia.edu
  2. bw2pw{at}virginia.edu
  1. ↵* Mengxue Zhang and Go Urabe contributed equally to this work.

View Full Text

Funding

  • NIH

    R01 HL133665
    L-W Guo
  • NIH

    R01HL-143469 and R01HL-129785
    KC Kent, L-W Guo
  • AHA pre-doctoral award

    17PRE33670865
    M Zhang
  • AHA post-doctoral award

    20POST35210967
    M Zhang
  • The Uehara Memorial Foundation in Japan

    T Shirasu
  • NIH

    R01HL116546, R01HL159900, R01AR070752
    R Han
  • Parent Project Muscular Dystrophy award

    R Han
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Epigenomic remodeling upon neointima formation
Mengxue Zhang, Go Urabe, Hatice Gulcin Ozer, Xiujie Xie, Amy Webb, Takuro Shirasu, Jing Li, Renzhi Han, K Craig Kent, Bowen Wang, Lian-Wang Guo
Life Science Alliance Feb 2022, 5 (5) e202101114; DOI: 10.26508/lsa.202101114

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Epigenomic remodeling upon neointima formation
Mengxue Zhang, Go Urabe, Hatice Gulcin Ozer, Xiujie Xie, Amy Webb, Takuro Shirasu, Jing Li, Renzhi Han, K Craig Kent, Bowen Wang, Lian-Wang Guo
Life Science Alliance Feb 2022, 5 (5) e202101114; DOI: 10.26508/lsa.202101114
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Volume 5, No. 5
May 2022
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