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About the Cover

May 2022 | Volume 5, No. 5

Research Articles

  • Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
    Open Access
    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting

    Jennifer Reck, Nicole Beuret, Erhan Demirci, Cristina Prescianotto-Baschong, Martin Spiess

    Jennifer Reck ... Martin Spiess

    Published 27 January 2022

    Small disulfide loops of several peptide hormones are shown to promote aggregation of reporter proteins in cultured cells and to act as novel signals for sorting into secretory granules by self-aggregation.

  • Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection
    Open Access
    Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection

    Martin Scherzer, Fosco Giordano, Maria Solé Ferran, Lena Ström

    Martin Scherzer ... Lena Ström

    Published 27 January 2022

    DSB recruitment of the cohesin loader Scc2/4 relies on Tel1 and γH2A, but contrary to cohesin not on Mec1; binding emanates from the break site and depends on as well as coincides with end resection.

  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia
    Open Access
    Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia

    Loïc Mangnier, Charles Joly-Beauparlant, Arnaud Droit, Steve Bilodeau, Alexandre Bureau

    Loïc Mangnier ... Alexandre Bureau

    Published 27 January 2022

    Genes and their regulatory elements are organized in neurons within 3D networks which model functional structures and explain schizophrenia genetic etiology.

  • Refining the domain architecture model of the replication origin firing factor Treslin/TICRR
    Open Access
    Refining the domain architecture model of the replication origin firing factor Treslin/TICRR

    Pedro Ferreira, Luis Sanchez-Pulido, Anika Marko, Chris P Ponting, Dominik Boos

    Pedro Ferreira ... Dominik Boos

    Published 28 January 2022

    The replication origin firing factor Treslin/TICRR comprises an essential Sld3-like core that requires the flanking Ku70-like N-terminal and the C-terminal domains for efficient origin firing.

  • Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells
    Open Access
    Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells

    Aneesha Kohli, Lucie Sauerhering, Sarah K Fehling, Kevin Klann, Helmut Geiger, Stephan Becker, Benjamin Koch, Patrick C Baer, Thomas Strecker, Christian Münch

    Aneesha Kohli ... Christian Münch

    Published 2 February 2022

    Translatome and proteome analyses of human proximal and distal tubular cells during coronavirus infection reveal distinctive host cell response patterns important for viral replication and renal pathology.

  • Environmental control of Pub1 (NEDD4 family E3 ligase) in <em>Schizosaccharomyces pombe</em> is regulated by TORC2 and Gsk3
    Open Access
    Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3

    Tingting Wang, Philip Woodman, Sean J Humphrey, Janni Petersen

    Tingting Wang ... Janni Petersen

    Published 4 February 2022

    The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake.

  • MMD-associated <em>RNF213</em> SNPs encode dominant-negative alleles that globally impair ubiquitylation
    Open Access
    MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation

    Abhishek Bhardwaj, Robert S Banh, Wei Zhang, Sachdev S Sidhu, Benjamin G Neel

    Abhishek Bhardwaj ... Benjamin G Neel

    Published 8 February 2022

    MMD-associated SNPs of RNF213 encode dominant-negative alleles that globally impair ubiquitylation by RNF213-UBE2D2.

  • Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)
    Open Access
    Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)

    Claudia Dominici, Stéphane Richard

    Claudia Dominici ... Stéphane Richard

    Published 14 February 2022

    The RNA-binding protein Quaking (QKI) is a post-transcriptional regulator of genes encoding polarity proteins in muscle stem cells. Loss of QKI in MuSCs results in reduced myogenic progenitors and a striking muscle regeneration defect.

  • Human <em>BRCA</em> pathogenic variants were originated during recent human history
    Open Access
    Human BRCA pathogenic variants were originated during recent human history

    Jiaheng Li, Bojin Zhao, Teng Huang, Zixin Qin, San Ming Wang

    Jiaheng Li ... San Ming Wang

    Published 14 February 2022

    Evolutionary origin of pathogenic variants in human BRCA1 and BRCA2.

  • Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast
    Open Access
    Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast

    Istvan T Kleijn, Amalia Martínez-Segura, François Bertaux, Malika Saint, Holger Kramer, Vahid Shahrezaei, Samuel Marguerat

    Istvan T Kleijn ... Samuel Marguerat

    Published 28 February 2022

    During growth on nitrogen sources, growth-rate-correlated gene expression is a trade-off between the stress and growth programmes, whereas medium-specific gene expression reflects metabolic states.

  • Angioplasty induces epigenomic remodeling in injured arteries
    Open Access
    Angioplasty induces epigenomic remodeling in injured arteries

    Mengxue Zhang, Go Urabe, Hatice Gulcin Ozer, Xiujie Xie, Amy Webb, Takuro Shirasu, Jing Li, Renzhi Han, K Craig Kent, Bowen Wang, Lian-Wang Guo

    Mengxue Zhang ... Lian-Wang Guo

    Published 15 February 2022

    This is the first in vivo epigenomic survey revealing genome-wide loci-specific chromatin mark redistribution after angioplasty; the underlying epigenetic regulations may inform therapeutic targeting.

  • The m6A(m)-independent role of FTO in regulating WNT signaling pathways
    Open Access
    The m6A(m)-independent role of FTO in regulating WNT signaling pathways

    Hyunjoon Kim, Soohyun Jang, Young-suk Lee

    Hyunjoon Kim ... Young-suk Lee

    Published 15 February 2022

    This study extends the regulatory role of RNA demethylase FTO and reveals its noncanonical function in WNT signaling that is independent of its enzymatic activity.

  • Quantitative profiling of adaptation to cyclin E overproduction
    Open Access
    Quantitative profiling of adaptation to cyclin E overproduction

    Juanita C Limas, Amiee N Littlejohn, Amy M House, Katarzyna M Kedziora, Brandon L Mouery, Boyang Ma, Dalia Fleifel, Andrea Walens, Maria M Aleman, Daniel Dominguez, Jeanette Gowen Cook

    Juanita C Limas ... Jeanette Gowen Cook

    Published 16 February 2022

    Detailed analysis of individual human cells responding then adapting to the stress of chronic cyclin E overproduction, which inhibits DNA replication origin licensing by inducing premature S phase.

  • Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides
    Open Access
    Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides

    Toshiaki Tanaka, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, Toshiyuki Ikoma

    Toshiaki Tanaka ... Toshiyuki Ikoma

    Published 18 February 2022

    Procollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.

  • ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells
    Open Access
    ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells

    Shikshya Shrestha, Anthony Lamattina, Gustavo Pacheco-Rodriguez, Julie Ng, Xiaoli Liu, Abhijeet Sonawane, Jewel Imani, Weiliang Qiu, Kosmas Kosmas, Pierce Louis, Anne Hentschel, Wendy K Steagall, Rieko Onishi, Helen Christou, Elizabeth P Henske, Kimberly Glass, Mark A Perrella, Joel Moss, Kelan Tantisira, Souheil El-Chemaly

    Shikshya Shrestha ... Souheil El-Chemaly

    Published 18 February 2022

    In tuberin-deficient cells, SYK regulates ETV2 nuclear translocation, where it regulated Parpbp expression. Silencing Etv2 or Parpbp induces ER stress–mediated cell death in tuberin-deficient cells.

  • Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors
    Open Access
    Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors

    Nabil Rabhi, Kathleen Desevin, Anna C Belkina, Andrew Tilston-Lunel, Xaralabos Varelas, Matthew D Layne, Stephen R Farmer

    Nabil Rabhi ... Stephen R Farmer

    Published 18 February 2022

    This study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.

  • Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs
    Open Access
    Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs

    Alexandra Papaioannou, Federica Centonze, Alice Metais, Marion Maurel, Luc Negroni, Matías Gonzalez-Quiroz, Sayyed Jalil Mahdizadeh, Gabriella Svensson, Ensieh Zare, Alice Blondel, Albert C Koong, Claudio Hetz, Rémy Pedeux, Michel L Tremblay, Leif A Eriksson, Eric Chevet

    Alexandra Papaioannou ... Eric Chevet

    Published 22 February 2022

    The tRNA ligase RtcB is tyrosine phosphorylated upon ER stress which in turn leads to modulation of XBP1 mRNA splicing and IRE1 signaling outputs.

  • The expression of essential selenoproteins during development requires SECIS-binding protein 2–like
    Open Access
    The expression of essential selenoproteins during development requires SECIS-binding protein 2–like

    Nora T Kiledjian, Rushvi Shah, Michael B Vetick, Paul R Copeland

    Nora T Kiledjian ... Paul R Copeland

    Published 24 February 2022

    This work reveals that the Sbp2 paralogue, Secisbp2-like, is required for selective selenoprotein synthesis when the function of Sbp2 is compromised.

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Volume 5, No. 5
May 2022
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