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Research Articles
Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sortingSmall disulfide loops of several peptide hormones are shown to promote aggregation of reporter proteins in cultured cells and to act as novel signals for sorting into secretory granules by self-aggregation.
Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resectionDSB recruitment of the cohesin loader Scc2/4 relies on Tel1 and γH2A, but contrary to cohesin not on Mec1; binding emanates from the break site and depends on as well as coincides with end resection.
Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophreniaGenes and their regulatory elements are organized in neurons within 3D networks which model functional structures and explain schizophrenia genetic etiology.
Refining the domain architecture model of the replication origin firing factor Treslin/TICRRThe replication origin firing factor Treslin/TICRR comprises an essential Sld3-like core that requires the flanking Ku70-like N-terminal and the C-terminal domains for efficient origin firing.
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cellsTranslatome and proteome analyses of human proximal and distal tubular cells during coronavirus infection reveal distinctive host cell response patterns important for viral replication and renal pathology.
Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake.
MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylationMMD-associated SNPs of RNF213 encode dominant-negative alleles that globally impair ubiquitylation by RNF213-UBE2D2.
Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)The RNA-binding protein Quaking (QKI) is a post-transcriptional regulator of genes encoding polarity proteins in muscle stem cells. Loss of QKI in MuSCs results in reduced myogenic progenitors and a striking muscle regeneration defect.
Human BRCA pathogenic variants were originated during recent human historyEvolutionary origin of pathogenic variants in human BRCA1 and BRCA2.
Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeastDuring growth on nitrogen sources, growth-rate-correlated gene expression is a trade-off between the stress and growth programmes, whereas medium-specific gene expression reflects metabolic states.
Angioplasty induces epigenomic remodeling in injured arteriesThis is the first in vivo epigenomic survey revealing genome-wide loci-specific chromatin mark redistribution after angioplasty; the underlying epigenetic regulations may inform therapeutic targeting.
The m6A(m)-independent role of FTO in regulating WNT signaling pathwaysThis study extends the regulatory role of RNA demethylase FTO and reveals its noncanonical function in WNT signaling that is independent of its enzymatic activity.
Quantitative profiling of adaptation to cyclin E overproductionDetailed analysis of individual human cells responding then adapting to the stress of chronic cyclin E overproduction, which inhibits DNA replication origin licensing by inducing premature S phase.
Visualized procollagen Iα1 demonstrates the intracellular processing of propeptidesProcollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.
ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cellsIn tuberin-deficient cells, SYK regulates ETV2 nuclear translocation, where it regulated Parpbp expression. Silencing Etv2 or Parpbp induces ER stress–mediated cell death in tuberin-deficient cells.
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitorsThis study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputsThe tRNA ligase RtcB is tyrosine phosphorylated upon ER stress which in turn leads to modulation of XBP1 mRNA splicing and IRE1 signaling outputs.
The expression of essential selenoproteins during development requires SECIS-binding protein 2–likeThis work reveals that the Sbp2 paralogue, Secisbp2-like, is required for selective selenoprotein synthesis when the function of Sbp2 is compromised.
