Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law

Xudong Zou; Bernhard Schaefke; Yisheng Li; Fujian Jia; Wei Sun; Guipeng Li; Weizheng Liang; Tristan Reif; Florian Heyd; Qingsong Gao; Shuye Tian; Yanping Li; Yisen Tang; Liang Fang; Yuhui Hu; Wei Chen

doi:10.26508/lsa.202101333

Research Article

Open Access

Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law

View ORCID ProfileXudong Zou, View ORCID ProfileBernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, View ORCID ProfileLiang Fang, View ORCID ProfileYuhui Hu, View ORCID ProfileWei Chen Correspondence email

Xudong Zou

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Conceptualization, Data curation, Software, Formal analysis, Methodology, Project administration, Writing—original draft, review, and editing

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Bernhard Schaefke

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China

Roles: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing—review and editing

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Yisheng Li

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Data curation, Formal analysis, Writing—review and editing

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Fujian Jia

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Formal analysis

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Wei Sun

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Resources, Data curation

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Guipeng Li

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China

Roles: Software, Methodology

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Weizheng Liang

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Validation

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Tristan Reif

4Institute for Biochemistry, Freie Universität Berlin, Berlin, Germany

Roles: Formal analysis

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Florian Heyd

4Institute for Biochemistry, Freie Universität Berlin, Berlin, Germany

Roles: Resources

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Qingsong Gao

5Laboratory for Systems Biology and Functional Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany

Roles: Methodology

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Shuye Tian

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Data curation, Validation

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Yanping Li

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Data curation, Validation

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Yisen Tang

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Data curation, Validation

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Liang Fang

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China

Roles: Conceptualization, Validation

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ORCID record for Liang Fang

Yuhui Hu

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

Roles: Methodology, Writing—review and editing

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Wei Chen

1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China

Roles: Conceptualization, Supervision, Funding acquisition, Investigation, Methodology, Project administration, Writing—review and editing

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ORCID record for Wei Chen
For correspondence: chenw@sustech.edu.cn

Published 30 December 2021. DOI: 10.26508/lsa.202101333

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Citation Tools

Splicing divergence in hybrid mice

Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen

Life Science Alliance Dec 2021, 5 (4) e202101333; DOI: 10.26508/lsa.202101333