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Research Article
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Open Access

Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law

View ORCID ProfileXudong Zou, View ORCID ProfileBernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, View ORCID ProfileLiang Fang, View ORCID ProfileYuhui Hu, View ORCID ProfileWei Chen  Correspondence email
Xudong Zou
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Conceptualization, Data curation, Software, Formal analysis, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Xudong Zou
Bernhard Schaefke
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
Roles: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing—review and editing
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  • ORCID record for Bernhard Schaefke
Yisheng Li
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Data curation, Formal analysis, Writing—review and editing
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Fujian Jia
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Formal analysis
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Wei Sun
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Resources, Data curation
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Guipeng Li
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
Roles: Software, Methodology
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Weizheng Liang
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Validation
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Tristan Reif
4Institute for Biochemistry, Freie Universität Berlin, Berlin, Germany
Roles: Formal analysis
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Florian Heyd
4Institute for Biochemistry, Freie Universität Berlin, Berlin, Germany
Roles: Resources
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Qingsong Gao
5Laboratory for Systems Biology and Functional Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany
Roles: Methodology
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Shuye Tian
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Data curation, Validation
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Yanping Li
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Data curation, Validation
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Yisen Tang
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Data curation, Validation
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Liang Fang
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
Roles: Conceptualization, Validation
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Yuhui Hu
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
Roles: Methodology, Writing—review and editing
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Wei Chen
1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
Roles: Conceptualization, Supervision, Funding acquisition, Investigation, Methodology, Project administration, Writing—review and editing
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  • ORCID record for Wei Chen
  • For correspondence: chenw@sustech.edu.cn
Published 30 December 2021. DOI: 10.26508/lsa.202101333
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Article Information

vol. 5 no. 4 e202101333
DOI 
https://doi.org/10.26508/lsa.202101333
PubMed 
34969779

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received December 10, 2021
  • Revision received December 20, 2021
  • Accepted December 20, 2021
  • Published online December 30, 2021.

Copyright & Usage 
© 2021 Zou et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Xudong Zou, Conceptualization, Data curation, Software, Formal analysis, Methodology, Project administration, Writing—original draft, review, and editing1,2,*,
  2. Bernhard Schaefke, Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing—review and editing1,2,3,*,
  3. Yisheng Li, Data curation, Formal analysis, Writing—review and editing2,
  4. Fujian Jia, Formal analysis2,
  5. Wei Sun, Resources, Data curation2,
  6. Guipeng Li, Software, Methodology1,2,3,
  7. Weizheng Liang, Validation2,
  8. Tristan Reif, Formal analysis4,
  9. Florian Heyd, Resources4,
  10. Qingsong Gao, Methodology5,
  11. Shuye Tian, Data curation, Validation1,2,
  12. Yanping Li, Data curation, Validation2,
  13. Yisen Tang, Data curation, Validation2,
  14. Liang Fang, Conceptualization, Validation1,2,3,
  15. Yuhui Hu, Methodology, Writing—review and editing1,2 and
  16. Wei Chen, Conceptualization, Supervision, Funding acquisition, Investigation, Methodology, Project administration, Writing—review and editing1,2,3⇑
  1. 1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
  2. 2Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
  3. 3Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
  4. 4Institute for Biochemistry, Freie Universität Berlin, Berlin, Germany
  5. 5Laboratory for Systems Biology and Functional Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany
  1. Correspondence: chenw{at}sustech.edu.cn
  1. ↵* Xudong Zou and Bernhard Schaefke contributed equally to this work.

  • Xudong Zou’s present address is Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.

  • Bernhard Schaefke’s present address is The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science–Shenzhen Fundamental Research Institutions, Shenzhen, China.

  • Wei Sun’s present address is Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.

  • Qingsong Gao’s present address is Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA.

View Full Text

Funding

  • Shenzhen Key Laboratory of Gene Regulation and Systems Biology

    ZDSYS20200811144002008
  • Shenzhen Science and Technology Program

    KQTD20180411143432337
  • Science and Technology Innovation Commission of the Shenzhen Municipal Government

    JCYJ20180504165804015
  • Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

    2019SHIBS0002
  • National Natural Science Foundation of China

    31861133013, 31970601, and 31771443
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Splicing divergence in hybrid mice
Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen
Life Science Alliance Dec 2021, 5 (4) e202101333; DOI: 10.26508/lsa.202101333

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Splicing divergence in hybrid mice
Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao, Shuye Tian, Yanping Li, Yisen Tang, Liang Fang, Yuhui Hu, Wei Chen
Life Science Alliance Dec 2021, 5 (4) e202101333; DOI: 10.26508/lsa.202101333
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Volume 5, No. 4
April 2022
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