Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension

Sonal Dahale; Jorge Ruiz-Orera; Jan Silhavy; Norbert Hübner; Sebastiaan van Heesch; Michal Pravenec; Santosh S Atanur

doi:10.26508/lsa.202101234

Research Article

Open Access

Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension

Sonal Dahale, Jorge Ruiz-Orera, Jan Silhavy, Norbert Hübner, View ORCID ProfileSebastiaan van Heesch, Michal Pravenec, View ORCID ProfileSantosh S Atanur Correspondence email

Sonal Dahale

1Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK

2Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

Roles: Software, Formal analysis

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Jorge Ruiz-Orera

3Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

Roles: Validation (promoter shift in Insr gene)

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Jan Silhavy

4Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic

Roles: Resources

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Norbert Hübner

3Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

5Charité -Universitätsmedizin, Berlin, Germany

6DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany

Roles: Validation (promoter shift in Insr gene)

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Sebastiaan van Heesch

7Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

Roles: Validation (promoter shift in Insr gene)

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ORCID record for Sebastiaan van Heesch

Michal Pravenec

4Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic

Roles: Resources, Writing—review and editing

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Santosh S Atanur

1Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK

8The National Institute for Health Research, Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK

Roles: Conceptualization, Software, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Santosh S Atanur
For correspondence: santosh.atanur@imperial.ac.uk

Published 7 January 2022. DOI: 10.26508/lsa.202101234

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Alternative promoter usage in a rat model of hypertension