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Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension

Sonal Dahale, Jorge Ruiz-Orera, Jan Silhavy, Norbert Hübner, View ORCID ProfileSebastiaan van Heesch, Michal Pravenec, View ORCID ProfileSantosh S Atanur  Correspondence email
Sonal Dahale
1Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK
2Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Roles: Software, Formal analysis
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Jorge Ruiz-Orera
3Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
Roles: Validation (promoter shift in Insr gene)
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Jan Silhavy
4Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
Roles: Resources
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Norbert Hübner
3Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
5Charité -Universitätsmedizin, Berlin, Germany
6DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany
Roles: Validation (promoter shift in Insr gene)
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Sebastiaan van Heesch
7Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
Roles: Validation (promoter shift in Insr gene)
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  • ORCID record for Sebastiaan van Heesch
Michal Pravenec
4Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
Roles: Resources, Writing—review and editing
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Santosh S Atanur
1Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK
8The National Institute for Health Research, Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK
Roles: Conceptualization, Software, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Santosh S Atanur
  • For correspondence: santosh.atanur@imperial.ac.uk
Published 7 January 2022. DOI: 10.26508/lsa.202101234
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Article Information

vol. 5 no. 4 e202101234
DOI 
https://doi.org/10.26508/lsa.202101234
PubMed 
34996843

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received September 15, 2021
  • Revision received December 26, 2021
  • Accepted December 28, 2021
  • Published online January 7, 2022.

Copyright & Usage 
© 2022 Dahale et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Sonal Dahale, Software, Formal analysis1,2,
  2. Jorge Ruiz-Orera, Validation (promoter shift in Insr gene)3,
  3. Jan Silhavy, Resources4,
  4. Norbert Hübner, Validation (promoter shift in Insr gene)3,5,6,
  5. Sebastiaan van Heesch, Validation (promoter shift in Insr gene)7,
  6. Michal Pravenec, Resources, Writing—review and editing4 and
  7. Santosh S Atanur, Conceptualization, Software, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,8⇑
  1. 1Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK
  2. 2Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
  3. 3Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
  4. 4Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
  5. 5Charité -Universitätsmedizin, Berlin, Germany
  6. 6DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany
  7. 7Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
  8. 8The National Institute for Health Research, Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK
  1. Correspondence: santosh.atanur{at}imperial.ac.uk
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Alternative promoter usage in a rat model of hypertension
Sonal Dahale, Jorge Ruiz-Orera, Jan Silhavy, Norbert Hübner, Sebastiaan van Heesch, Michal Pravenec, Santosh S Atanur
Life Science Alliance Jan 2022, 5 (4) e202101234; DOI: 10.26508/lsa.202101234

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Alternative promoter usage in a rat model of hypertension
Sonal Dahale, Jorge Ruiz-Orera, Jan Silhavy, Norbert Hübner, Sebastiaan van Heesch, Michal Pravenec, Santosh S Atanur
Life Science Alliance Jan 2022, 5 (4) e202101234; DOI: 10.26508/lsa.202101234
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Volume 5, No. 4
April 2022
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