Research Article
Open Access
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
View ORCID ProfileJose F Varona Correspondence email, Pedro Landete, View ORCID ProfileJose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, View ORCID ProfileJesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, View ORCID ProfileJulio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, View ORCID ProfileSonia Zuñiga, Isabel Sola, View ORCID ProfileJordi Rodon, Julia Vergara-Alert, View ORCID ProfileNuria Izquierdo-Useros, View ORCID ProfileSalvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, View ORCID ProfileKris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, View ORCID ProfileLucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, View ORCID ProfileKirsten Obernier, View ORCID ProfileBriana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, View ORCID ProfileNevan J Krogan, Jose M Jimeno, View ORCID ProfileAdolfo Garcia-Sastre
Jose F Varona
1Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain
2Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain
Roles: Conceptualization, Investigation, Writing—original draft, review, and editing
Pedro Landete
3Hospital Universitario La Princesa, Madrid, Spain
4Universidad Autónoma de Madrid, Madrid, Spain
Roles: Investigation
Jose A Lopez-Martin
5Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain
Roles: Conceptualization, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing—original draft, review, and editing
Vicente Estrada
6Hospital Clínico San Carlos, Madrid, Spain
7Universidad Complutense de Madrid, Madrid, Spain
Roles: Conceptualization, Investigation
Roger Paredes
8Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain
9Hospital Germans Trias I Pujol, Barcelona, Spain
Roles: Conceptualization, Investigation
Pablo Guisado-Vasco
10Hospital Universitario Quironsalud Madrid, Madrid, Spain
11Universidad Europea, Madrid, Spain
Roles: Investigation
Lucia Fernandez de Orueta
11Universidad Europea, Madrid, Spain
12Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain
Roles: Investigation
Miguel Torralba
13Health Sciences Faculty, University of Alcalá, Madrid, Spain
14Guadalajara University Hospital, Guadalajara, Spain
Roles: Investigation
Jesus Fortun
15Hospital Universitario Ramón y Cajal, Madrid, Spain
Roles: Conceptualization, Investigation
Roberto Vates
12Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain
Roles: Investigation
Jose Barberan
1Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain
2Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain
Roles: Conceptualization, Investigation
Bonaventura Clotet
8Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain
9Hospital Germans Trias I Pujol, Barcelona, Spain
16Universitat Autònoma de Barcelona, Barcelona, Spain
17Universitat de Vic, Universitat Central de Catalunya, Barcelona, Spain
Roles: Investigation
Julio Ancochea
3Hospital Universitario La Princesa, Madrid, Spain
4Universidad Autónoma de Madrid, Madrid, Spain
18Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Roles: Investigation
Daniel Carnevali
10Hospital Universitario Quironsalud Madrid, Madrid, Spain
11Universidad Europea, Madrid, Spain
Roles: Investigation
Noemi Cabello
19Infectious Diseases Department, Clinico San Carlos University Hospital, Madrid, Spain
Roles: Investigation
Lourdes Porras
20Internal Medicine, Hospital General de Ciudad Real, Ciudad Real, Spain
Roles: Investigation
Paloma Gijon
21Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
Roles: Investigation
Alfonso Monereo
12Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain
Roles: Investigation
Daniel Abad
11Universidad Europea, Madrid, Spain
12Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain
Roles: Investigation
Sonia Zuñiga
22Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
Roles: Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration
Isabel Sola
22Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
Roles: Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration
Jordi Rodon
23IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Validation, Investigation
Julia Vergara-Alert
23IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain
Roles: Conceptualization, Data curation, Investigation
Nuria Izquierdo-Useros
24IrsiCaixa AIDS Research Institute, Barcelona, Spain
25Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain
Roles: Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration, Writing—review and editing
Salvador Fudio
26Clinical Pharmacology Unit, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Software, Formal analysis, Visualization, Methodology
Maria Jose Pontes
27Medical Affairs, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Project administration
Beatriz de Rivas
27Medical Affairs, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Project administration
Patricia Giron de Velasco
5Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain
Roles: Data curation, Formal analysis, Investigation, Visualization, Methodology
Antonio Nieto
28Bio Statistics Unit, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Formal analysis
Javier Gomez
28Bio Statistics Unit, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Formal analysis, Visualization
Pablo Aviles
29Preclinical Unit, Pharmamar, Madrid, Spain
Roles: Investigation
Rubin Lubomirov
26Clinical Pharmacology Unit, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Software, Formal analysis, Visualization, Methodology
Alvaro Belgrano
28Bio Statistics Unit, PharmaMar, Madrid, Spain
Roles: Conceptualization, Data curation, Formal analysis
Belen Sopesen
5Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain
30Sylentis, SAU, Madrid, Spain
31Biocross, SL, Valladolid, Spain
Roles: Investigation
Kris M White
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Project administration, Writing—original draft, review, and editing
Romel Rosales
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Resources, Supervision, Validation, Investigation
Soner Yildiz
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Resources, Supervision, Validation, Investigation
Ann-Kathrin Reuschl
34Division of Infection and Immunity, University College London, London, UK
Roles: Formal analysis, Investigation
Lucy G Thorne
34Division of Infection and Immunity, University College London, London, UK
Roles: Formal analysis, Investigation
Clare Jolly
34Division of Infection and Immunity, University College London, London, UK
Roles: Formal analysis, Investigation
Greg J Towers
34Division of Infection and Immunity, University College London, London, UK
Roles: Formal analysis, Investigation
Lorena Zuliani-Alvarez
35Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
36J David Gladstone Institutes, San Francisco, CA, USA
37QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA
38Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
Roles: Formal analysis, Investigation
Mehdi Bouhaddou
35Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
36J David Gladstone Institutes, San Francisco, CA, USA
37QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA
38Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
Roles: Formal analysis, Investigation
Kirsten Obernier
35Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
36J David Gladstone Institutes, San Francisco, CA, USA
37QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA
38Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
Roles: Formal analysis, Investigation
Briana L McGovern
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Resources, Supervision, Validation, Investigation
M Luis Rodriguez
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Resources, Supervision, Validation, Investigation
Luis Enjuanes
22Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Validation, Investigation, Project administration
Jose M Fernandez-Sousa
39Pharmamar, Madrid, Spain
Roles: Conceptualization, Funding acquisition, Methodology
Nevan J Krogan
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
35Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
36J David Gladstone Institutes, San Francisco, CA, USA
37QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA
38Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Writing—original draft, Project administration
Jose M Jimeno
5Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Investigation, Methodology, Project administration, Writing—original draft, review, and editing
Adolfo Garcia-Sastre
32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
40Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
41Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Project administration, Writing—review and editing
Published 10 January 2022. DOI: 10.26508/lsa.202101200
Proof-of-concept study of plitidepsin in COVID-19
Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre
Life Science Alliance Jan 2022, 5 (4) e202101200; DOI: 10.26508/lsa.202101200
Proof-of-concept study of plitidepsin in COVID-19
Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre
Life Science Alliance Jan 2022, 5 (4) e202101200; DOI: 10.26508/lsa.202101200
In this Issue
Volume 5, No. 4
April 2022
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