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History
- Received August 18, 2021
- Revision received December 24, 2021
- Accepted December 28, 2021
- Published online January 10, 2022.
Copyright & Usage
© 2022 Varona et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
Author Information
- Jose F Varona, Conceptualization, Investigation, Writing—original draft, review, and editing1,2⇑,
- Pedro Landete, Investigation3,4,
- Jose A Lopez-Martin, Conceptualization, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing—original draft, review, and editing5,
- Vicente Estrada, Conceptualization, Investigation6,7,
- Roger Paredes, Conceptualization, Investigation8,9,
- Pablo Guisado-Vasco, Investigation10,11,
- Lucia Fernandez de Orueta, Investigation11,12,
- Miguel Torralba, Investigation13,14,
- Jesus Fortun, Conceptualization, Investigation15,
- Roberto Vates, Investigation12,
- Jose Barberan, Conceptualization, Investigation1,2,
- Bonaventura Clotet, Investigation8,9,16,17,
- Julio Ancochea, Investigation3,4,18,
- Daniel Carnevali, Investigation10,11,
- Noemi Cabello, Investigation19,
- Lourdes Porras, Investigation20,
- Paloma Gijon, Investigation21,
- Alfonso Monereo, Investigation12,
- Daniel Abad, Investigation11,12,
- Sonia Zuñiga, Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration22,
- Isabel Sola, Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration22,
- Jordi Rodon, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Validation, Investigation23,
- Julia Vergara-Alert, Conceptualization, Data curation, Investigation23,
- Nuria Izquierdo-Useros, Conceptualization, Resources, Data curation, Supervision, Validation, Investigation, Project administration, Writing—review and editing24,25,
- Salvador Fudio, Conceptualization, Data curation, Software, Formal analysis, Visualization, Methodology26,
- Maria Jose Pontes, Conceptualization, Data curation, Project administration27,
- Beatriz de Rivas, Conceptualization, Data curation, Project administration27,
- Patricia Giron de Velasco, Data curation, Formal analysis, Investigation, Visualization, Methodology5,
- Antonio Nieto, Conceptualization, Data curation, Formal analysis28,
- Javier Gomez, Conceptualization, Data curation, Formal analysis, Visualization28,
- Pablo Aviles, Investigation29,
- Rubin Lubomirov, Conceptualization, Data curation, Software, Formal analysis, Visualization, Methodology26,
- Alvaro Belgrano, Conceptualization, Data curation, Formal analysis28,
- Belen Sopesen, Investigation5,30,31,
- Kris M White, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Project administration, Writing—original draft, review, and editing32,33,
- Romel Rosales, Conceptualization, Resources, Supervision, Validation, Investigation32,33,
- Soner Yildiz, Conceptualization, Resources, Supervision, Validation, Investigation32,33,
- Ann-Kathrin Reuschl, Formal analysis, Investigation34,
- Lucy G Thorne, Formal analysis, Investigation34,
- Clare Jolly, Formal analysis, Investigation34,
- Greg J Towers, Formal analysis, Investigation34,
- Lorena Zuliani-Alvarez, Formal analysis, Investigation35,36,37,38,
- Mehdi Bouhaddou, Formal analysis, Investigation35,36,37,38,
- Kirsten Obernier, Formal analysis, Investigation35,36,37,38,
- Briana L McGovern, Conceptualization, Resources, Supervision, Validation, Investigation32,33,
- M Luis Rodriguez, Conceptualization, Resources, Supervision, Validation, Investigation32,33,
- Luis Enjuanes, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Validation, Investigation, Project administration22,
- Jose M Fernandez-Sousa, Conceptualization, Funding acquisition, Methodology39,
- Nevan J Krogan, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Writing—original draft, Project administration32,35,36,37,38,
- Jose M Jimeno, Conceptualization, Data curation, Formal analysis, Supervision, Investigation, Methodology, Project administration, Writing—original draft, review, and editing5,* and
- Adolfo Garcia-Sastre, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Project administration, Writing—review and editing32,33,40,41,*
- 1Departamento de Medicina Interna, Hospital Universitario HM Monteprincipe, HM Hospitales, Madrid, Spain
- 2Facultad de Medicina, Universidad San Pablo-CEU, Madrid, Spain
- 3Hospital Universitario La Princesa, Madrid, Spain
- 4Universidad Autónoma de Madrid, Madrid, Spain
- 5Virology and Inflammation Unit, PharmaMar, SA, Madrid, Spain
- 6Hospital Clínico San Carlos, Madrid, Spain
- 7Universidad Complutense de Madrid, Madrid, Spain
- 8Infectious Diseases Department, IrsiCaixa AIDS Research Institute, Barcelona, Spain
- 9Hospital Germans Trias I Pujol, Barcelona, Spain
- 10Hospital Universitario Quironsalud Madrid, Madrid, Spain
- 11Universidad Europea, Madrid, Spain
- 12Internal Medicine Department, Hospital Universitario de Getafe, Madrid, Spain
- 13Health Sciences Faculty, University of Alcalá, Madrid, Spain
- 14Guadalajara University Hospital, Guadalajara, Spain
- 15Hospital Universitario Ramón y Cajal, Madrid, Spain
- 16Universitat Autònoma de Barcelona, Barcelona, Spain
- 17Universitat de Vic, Universitat Central de Catalunya, Barcelona, Spain
- 18Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
- 19Infectious Diseases Department, Clinico San Carlos University Hospital, Madrid, Spain
- 20Internal Medicine, Hospital General de Ciudad Real, Ciudad Real, Spain
- 21Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
- 22Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
- 23IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra, Spain
- 24IrsiCaixa AIDS Research Institute, Barcelona, Spain
- 25Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain
- 26Clinical Pharmacology Unit, PharmaMar, Madrid, Spain
- 27Medical Affairs, PharmaMar, Madrid, Spain
- 28Bio Statistics Unit, PharmaMar, Madrid, Spain
- 29Preclinical Unit, Pharmamar, Madrid, Spain
- 30Sylentis, SAU, Madrid, Spain
- 31Biocross, SL, Valladolid, Spain
- 32Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 33Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 34Division of Infection and Immunity, University College London, London, UK
- 35Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA
- 36J David Gladstone Institutes, San Francisco, CA, USA
- 37QBI, Coronavirus Research Group (QCRG), San Francisco, CA, USA
- 38Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA
- 39Pharmamar, Madrid, Spain
- 40Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 41Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Correspondence: jfvarona{at}hmhospitales.com
↵* José M Jimeno and Adolfo García-Sastre contributed equally to this work.
Funding
Government of Spain
PIE_INTRAMURAL_ LINEA 1 - 202020E079; PIE_INTRAMURAL_CSIC-202020E043PharmaMar
N Izquierdo-UserosNational Institutes of Health
P50AI150476, U19AI135990, U19AI135972, R01AI143292, R01AI120694, and P01AI063302NJ KroganExcellence in Research Award
#133122PNJ KroganRoddenberry Foundation, QCRG philanthropic donors
NJ KroganDefense Advanced Research Projects Agency
#HR0011-19-2-0020CRIPT, NIAID supported Center of Excellence for Influenza Research and Response
75N93021C00014A García-SastreDARPA
HR0011-19-2-0020A García-SastreNIAID
U19AI142733, U19AI135972A García-SastreDoD
W81XWH-20-1-0270A García-SastreJPB Foundation, Open Philanthropy Project
2020-215611 (5384)A García-Sastre