Research Article
Open Access
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
View ORCID ProfileIrene Riera-Tur, View ORCID ProfileTillman Schäfer, View ORCID ProfileDaniel Hornburg, Archana Mishra, Miguel da Silva Padilha, Lorena Fernández-Mosquera, Dennis Feigenbutz, Patrick Auer, View ORCID ProfileMatthias Mann, Wolfgang Baumeister, View ORCID ProfileRüdiger Klein, Felix Meissner, View ORCID ProfileNuno Raimundo, View ORCID ProfileRubén Fernández-Busnadiego Correspondence email, View ORCID ProfileIrina Dudanova Correspondence email
Irene Riera-Tur
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
2Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Formal analysis, Investigation, Visualization
Tillman Schäfer
3Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
Roles: Formal analysis, Investigation, Visualization
Daniel Hornburg
4Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
5Experimental Systems Immunology Group, Max Planck Institute of Biochemistry, Martinsried, Germany
Roles: Formal analysis, Investigation, Visualization
Archana Mishra
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Formal analysis, Investigation
Miguel da Silva Padilha
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
2Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Formal analysis, Investigation, Visualization
Lorena Fernández-Mosquera
6The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Roles: Formal analysis, Investigation
Dennis Feigenbutz
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
2Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Investigation
Patrick Auer
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
2Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Investigation
Matthias Mann
4Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
Roles: Conceptualization, Supervision, Funding acquisition
Wolfgang Baumeister
3Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
Roles: Conceptualization, Supervision, Funding acquisition
Rüdiger Klein
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Conceptualization, Supervision, Funding acquisition
Felix Meissner
5Experimental Systems Immunology Group, Max Planck Institute of Biochemistry, Martinsried, Germany
10Department of Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany
Roles: Conceptualization, Supervision, Project administration
Nuno Raimundo
7Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA
Roles: Conceptualization, Supervision
Rubén Fernández-Busnadiego
3Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
8Institute of Neuropathology, University Medical Center Goettingen, Goettingen, Germany
9Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Goettingen, Goettingen, Germany
Roles: Conceptualization, Supervision, Project administration, Writing—original draft, review, and editing
Irina Dudanova
1Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, Martinsried, Germany
2Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
Roles: Conceptualization, Supervision, Visualization, Project administration, Writing—original draft, review, and editing
Published 21 December 2021. DOI: 10.26508/lsa.202101185
Aggregation-induced lysosomal defects in neurons
Irene Riera-Tur, Tillman Schäfer, Daniel Hornburg, Archana Mishra, Miguel da Silva Padilha, Lorena Fernández-Mosquera, Dennis Feigenbutz, Patrick Auer, Matthias Mann, Wolfgang Baumeister, Rüdiger Klein, Felix Meissner, Nuno Raimundo, Rubén Fernández-Busnadiego, Irina Dudanova
Life Science Alliance Dec 2021, 5 (3) e202101185; DOI: 10.26508/lsa.202101185
Aggregation-induced lysosomal defects in neurons
Irene Riera-Tur, Tillman Schäfer, Daniel Hornburg, Archana Mishra, Miguel da Silva Padilha, Lorena Fernández-Mosquera, Dennis Feigenbutz, Patrick Auer, Matthias Mann, Wolfgang Baumeister, Rüdiger Klein, Felix Meissner, Nuno Raimundo, Rubén Fernández-Busnadiego, Irina Dudanova
Life Science Alliance Dec 2021, 5 (3) e202101185; DOI: 10.26508/lsa.202101185
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Volume 5, No. 3
March 2022
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