β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

Jung-AA Woo; Yan Yan; Teresa R Kee; Sara Cazzaro; Kyle C McGill Percy; Xinming Wang; Tian Liu; Stephen B Liggett; David E Kang

doi:10.26508/lsa.202101183

Research Article

Open Access

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

View ORCID ProfileJung-AA Woo Correspondence email, Yan Yan, Teresa R Kee, Sara Cazzaro, Kyle C McGill Percy, Xinming Wang, Tian Liu, View ORCID ProfileStephen B Liggett, David E Kang

Jung-AA Woo

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

Roles: Conceptualization, Resources, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Jung-AA Woo
For correspondence: jaw330@case.edu

Yan Yan

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

2Department of Molecular Medicine, University of South Florida, College of Medicine, Tampa, FL, USA

Roles: Validation, Investigation, Methodology, Writing—review and editing

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Teresa R Kee

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

2Department of Molecular Medicine, University of South Florida, College of Medicine, Tampa, FL, USA

Roles: Data curation, Validation, Investigation, Methodology, Writing—review and editing

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Sara Cazzaro

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

2Department of Molecular Medicine, University of South Florida, College of Medicine, Tampa, FL, USA

Roles: Data curation, Validation, Investigation, Methodology, Writing—review and editing

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Kyle C McGill Percy

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

Roles: Data curation, Validation, Investigation, Methodology, Writing—review and editing

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Xinming Wang

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

Roles: Data curation, Validation, Investigation, Methodology, Writing—review and editing

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Tian Liu

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

Roles: Data curation, Validation, Visualization, Methodology, Writing—review and editing

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Stephen B Liggett

3Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, FL, USA

Roles: Resources, Validation, Investigation, Writing—review and editing

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ORCID record for Stephen B Liggett

David E Kang

1Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

4Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA

Roles: Conceptualization, Resources, Funding acquisition, Project administration, Writing—original draft, review, and editing

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Published 3 December 2021. DOI: 10.26508/lsa.202101183

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Reduced β-arrestin1 mitigates tauopathy in vivo