Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

Sabine Borchard; Stefanie Raschke; Krzysztof M Zak; Carola Eberhagen; Claudia Einer; Elisabeth Weber; Sandra M Müller; Bernhard Michalke; Josef Lichtmannegger; Albrecht Wieser; Tamara Rieder; Grzegorz M Popowicz; Jerzy Adamski; Martin Klingenspor; Andrew H Coles; Ruth Viana; Mikkel H Vendelbo; Thomas D Sandahl; Tanja Schwerdtle; Thomas Plitz; Hans Zischka

doi:10.26508/lsa.202101164

Research Article

Open Access

Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

Sabine Borchard, Stefanie Raschke, View ORCID ProfileKrzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, View ORCID ProfileSandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, View ORCID ProfileMartin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, View ORCID ProfileHans Zischka Correspondence email

Sabine Borchard

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Conceptualization, Data curation, Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stefanie Raschke

2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

3TraceAge–Deutsche Forschungsgemeinschaft Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (Forschungsgruppe 2558), Berlin-Potsdam-Jena-Wuppertal, Germany

Roles: Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Krzysztof M Zak

4Institute of Structural Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Krzysztof M Zak

Carola Eberhagen

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Claudia Einer

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elisabeth Weber

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sandra M Müller

2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sandra M Müller

Bernhard Michalke

5Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Josef Lichtmannegger

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Data curation, Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Albrecht Wieser

6Institute of Radiation Medicine, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tamara Rieder

7Technical University Munich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany

Roles: Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Grzegorz M Popowicz

4Institute of Structural Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

Roles: Data curation, Formal analysis, Validation, Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jerzy Adamski

8Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

9Lehrstuhl für Experimentelle Genetik, Technical University Munich, Freising-Weihenstephan, Germany

10Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Roles: Validation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Martin Klingenspor

11Chair of Molecular Nutritional Medicine, Technical University of Munich, School of Life Sciences Weihenstephan, Freising, Germany

12Else-Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany

Roles: Validation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Martin Klingenspor

Andrew H Coles

13Alexion AstraZeneca Rare Disease, Boston, MA, USA

Roles: Validation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ruth Viana

13Alexion AstraZeneca Rare Disease, Boston, MA, USA

Roles: Formal analysis, Funding acquisition, Validation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mikkel H Vendelbo

14Department of Nuclear Medicine and Positron Emission Tomography Centre, Aarhus University Hospital, Aarhus, Denmark

15Department of Biomedicine, Aarhus University, Aarhus C, Denmark

Roles: Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thomas D Sandahl

16Medical Department Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark

Roles: Resources, Investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tanja Schwerdtle

2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

3TraceAge–Deutsche Forschungsgemeinschaft Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (Forschungsgruppe 2558), Berlin-Potsdam-Jena-Wuppertal, Germany

Roles: Investigation, Methodology

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thomas Plitz

17Wilson Therapeutics AB, Stockholm, Sweden

Roles: Conceptualization

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hans Zischka

1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

7Technical University Munich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany

Roles: Conceptualization, Data curation, Supervision, Funding acquisition, Writing—original draft

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hans Zischka
For correspondence: zischka@helmholtz-muenchen.de

Published 2 December 2021. DOI: 10.26508/lsa.202101164

Article
Figures & Data
Info
Metrics
Reviewer Comments
PDF

You are using an old browser, click here to download PDF

PDF Container

PreviousNext

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for your interest in spreading the word on Life Science Alliance.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

Message Subject (Your Name) has sent you a message from Life Science Alliance

Message Body (Your Name) thought you would like to see the Life Science Alliance web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Citation Tools

High-affinity copper chelator

Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka

Life Science Alliance Dec 2021, 5 (3) e202101164; DOI: 10.26508/lsa.202101164