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Research Article
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Open Access

Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

Sabine Borchard, Stefanie Raschke, View ORCID ProfileKrzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, View ORCID ProfileSandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, View ORCID ProfileMartin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, View ORCID ProfileHans Zischka  Correspondence email
Sabine Borchard
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Conceptualization, Data curation, Investigation, Methodology
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Stefanie Raschke
2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
3TraceAge–Deutsche Forschungsgemeinschaft Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (Forschungsgruppe 2558), Berlin-Potsdam-Jena-Wuppertal, Germany
Roles: Investigation, Methodology
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Krzysztof M Zak
4Institute of Structural Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation
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  • ORCID record for Krzysztof M Zak
Carola Eberhagen
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation
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Claudia Einer
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation
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Elisabeth Weber
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation
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Sandra M Müller
2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Roles: Investigation
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  • ORCID record for Sandra M Müller
Bernhard Michalke
5Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation, Methodology
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Josef Lichtmannegger
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Data curation, Investigation, Methodology
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Albrecht Wieser
6Institute of Radiation Medicine, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Investigation, Methodology
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Tamara Rieder
7Technical University Munich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany
Roles: Investigation, Methodology
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Grzegorz M Popowicz
4Institute of Structural Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
Roles: Data curation, Formal analysis, Validation, Investigation, Methodology
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Jerzy Adamski
8Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
9Lehrstuhl für Experimentelle Genetik, Technical University Munich, Freising-Weihenstephan, Germany
10Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Roles: Validation
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Martin Klingenspor
11Chair of Molecular Nutritional Medicine, Technical University of Munich, School of Life Sciences Weihenstephan, Freising, Germany
12Else-Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany
Roles: Validation
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  • ORCID record for Martin Klingenspor
Andrew H Coles
13Alexion AstraZeneca Rare Disease, Boston, MA, USA
Roles: Validation
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Ruth Viana
13Alexion AstraZeneca Rare Disease, Boston, MA, USA
Roles: Formal analysis, Funding acquisition, Validation
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Mikkel H Vendelbo
14Department of Nuclear Medicine and Positron Emission Tomography Centre, Aarhus University Hospital, Aarhus, Denmark
15Department of Biomedicine, Aarhus University, Aarhus C, Denmark
Roles: Investigation
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Thomas D Sandahl
16Medical Department Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
Roles: Resources, Investigation
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Tanja Schwerdtle
2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
3TraceAge–Deutsche Forschungsgemeinschaft Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (Forschungsgruppe 2558), Berlin-Potsdam-Jena-Wuppertal, Germany
Roles: Investigation, Methodology
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Thomas Plitz
17Wilson Therapeutics AB, Stockholm, Sweden
Roles: Conceptualization
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Hans Zischka
1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
7Technical University Munich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany
Roles: Conceptualization, Data curation, Supervision, Funding acquisition, Writing—original draft
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  • ORCID record for Hans Zischka
  • For correspondence: zischka@helmholtz-muenchen.de
Published 2 December 2021. DOI: 10.26508/lsa.202101164
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Article Information

vol. 5 no. 3 e202101164
DOI 
https://doi.org/10.26508/lsa.202101164
PubMed 
34857647

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received July 19, 2021
  • Revision received November 16, 2021
  • Accepted November 17, 2021
  • Published online December 2, 2021.

Copyright & Usage 
© 2021 Borchard et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Sabine Borchard, Conceptualization, Data curation, Investigation, Methodology1,
  2. Stefanie Raschke, Investigation, Methodology2,3,
  3. Krzysztof M Zak, Investigation4,
  4. Carola Eberhagen, Investigation1,
  5. Claudia Einer, Investigation1,
  6. Elisabeth Weber, Investigation1,
  7. Sandra M Müller, Investigation2,
  8. Bernhard Michalke, Investigation, Methodology5,
  9. Josef Lichtmannegger, Data curation, Investigation, Methodology1,
  10. Albrecht Wieser, Investigation, Methodology6,
  11. Tamara Rieder, Investigation, Methodology7,
  12. Grzegorz M Popowicz, Data curation, Formal analysis, Validation, Investigation, Methodology4,
  13. Jerzy Adamski, Validation8,9,10,
  14. Martin Klingenspor, Validation11,12,
  15. Andrew H Coles, Validation13,
  16. Ruth Viana, Formal analysis, Funding acquisition, Validation13,
  17. Mikkel H Vendelbo, Investigation14,15,
  18. Thomas D Sandahl, Resources, Investigation16,
  19. Tanja Schwerdtle, Investigation, Methodology2,3,
  20. Thomas Plitz, Conceptualization17 and
  21. Hans Zischka, Conceptualization, Data curation, Supervision, Funding acquisition, Writing—original draft1,7⇑
  1. 1Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
  2. 2Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
  3. 3TraceAge–Deutsche Forschungsgemeinschaft Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (Forschungsgruppe 2558), Berlin-Potsdam-Jena-Wuppertal, Germany
  4. 4Institute of Structural Biology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
  5. 5Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
  6. 6Institute of Radiation Medicine, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
  7. 7Technical University Munich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany
  8. 8Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
  9. 9Lehrstuhl für Experimentelle Genetik, Technical University Munich, Freising-Weihenstephan, Germany
  10. 10Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  11. 11Chair of Molecular Nutritional Medicine, Technical University of Munich, School of Life Sciences Weihenstephan, Freising, Germany
  12. 12Else-Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany
  13. 13Alexion AstraZeneca Rare Disease, Boston, MA, USA
  14. 14Department of Nuclear Medicine and Positron Emission Tomography Centre, Aarhus University Hospital, Aarhus, Denmark
  15. 15Department of Biomedicine, Aarhus University, Aarhus C, Denmark
  16. 16Medical Department Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
  17. 17Wilson Therapeutics AB, Stockholm, Sweden
  1. Correspondence: zischka{at}helmholtz-muenchen.de
View Full Text

Funding

  • Wilson Therapeutics AB/Alexion AstraZeneca Rare Disease

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High-affinity copper chelator
Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka
Life Science Alliance Dec 2021, 5 (3) e202101164; DOI: 10.26508/lsa.202101164

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High-affinity copper chelator
Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka
Life Science Alliance Dec 2021, 5 (3) e202101164; DOI: 10.26508/lsa.202101164
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Volume 5, No. 3
March 2022
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