Table of Contents
Research Articles
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in ratsLiver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.
Fms-like tyrosine kinase 3 is a regulator of the cardiac side population in miceThis work shows that Flt3 signaling regulates the composition and functionality of the cardiac side population, which could be relevant for cardiovascular homeostasis under Flt3-inhibitory therapies.
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoitesInfusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damageThe blood–brain barrier endothelial cell monolayer becomes permeable to elevated copper loosely bound to albumin, which can be avoided by a high-affinity copper chelator but not by D-penicillamine.
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA systemMurine neural stem cell exosomes/microvesicles can work to reduce SARS-CoV-2, an effect that can be adaptively enhanced via viral RNA fragment stimulation, which requires the PIWI-piRNA system.
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagyGPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.
Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegansContrary to prior reports, this study shows that a loss of COMPASS components or SET1 activity reduces Caenorhabditis elegans lifespan, suggesting that as in yeast, H3K4 methylation is essential for normal longevity.
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicityUsing cryo-ET, cell biology, and proteomics, this study shows that aggregating proteins impair the autophagy-lysosomal pathway in neurons by sequestering a subunit of the AP-3 adaptor complex.
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity controlThe phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathwayCellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway.
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophilaBy using electron cryo-tomography and subtomogram average, this study reveals the assembly of T. thermophila axonemal MT doublet in wild type and mutant, showing its structure conservation and diversity compared to other organisms.
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasisNecrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.
CNVs with adaptive potential in Rangifer tarandus: genome architecture and new annotated assemblyNext-generation sequencing of three caribou ecotypes aligned to a new annotated genome assembly revealed divergent CNVs, including genes with annotations in line with adaptation.
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrityThis study describes the the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function.
Resources
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingThis study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulationA reporter system for quantitative measurements of NMD-sensitive mRNA and protein levels in mammalian cells shows that NMD suppresses protein levels to a greater degree than RNA levels.
