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Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy

Emma V Rusilowicz-Jones, View ORCID ProfileFrancesco G Barone, Fernanda Martins Lopes, Elezabeth Stephen, View ORCID ProfileHeather Mortiboys, Sylvie Urbé  Correspondence email, View ORCID ProfileMichael J Clague  Correspondence email
Emma V Rusilowicz-Jones
1Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
Roles: Conceptualization, Data curation, Formal analysis, Investigation, Funding acquisition, Methodology, Writing—original draft, review, and editing
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Francesco G Barone
1Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
Roles: Conceptualization, Data curation, Formal analysis, Investigation, Writing—review and editing
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  • ORCID record for Francesco G Barone
Fernanda Martins Lopes
2Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
Roles: Formal analysis, Investigation
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Elezabeth Stephen
2Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
Roles: Formal analysis, Investigation
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Heather Mortiboys
2Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing
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  • ORCID record for Heather Mortiboys
Sylvie Urbé
1Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
Roles: Conceptualization, Supervision, Funding acquisition, Visualization, Project administration, Writing—original draft, review, and editing
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  • For correspondence: urbe@liv.ac.uk
Michael J Clague
1Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing
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  • For correspondence: clague@liv.ac.uk
Published 29 November 2021. DOI: 10.26508/lsa.202101287
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Article Information

vol. 5 no. 2 e202101287
DOI 
https://doi.org/10.26508/lsa.202101287
PubMed 
34844982

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received November 3, 2021
  • Revision received November 10, 2021
  • Accepted November 12, 2021
  • Published online November 29, 2021.

Copyright & Usage 
© 2021 Rusilowicz-Jones et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Emma V Rusilowicz-Jones, Conceptualization, Data curation, Formal analysis, Investigation, Funding acquisition, Methodology, Writing—original draft, review, and editing1,*,
  2. Francesco G Barone, Conceptualization, Data curation, Formal analysis, Investigation, Writing—review and editing1,*,
  3. Fernanda Martins Lopes, Formal analysis, Investigation2,
  4. Elezabeth Stephen, Formal analysis, Investigation2,
  5. Heather Mortiboys, Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing2,
  6. Sylvie Urbé, Conceptualization, Supervision, Funding acquisition, Visualization, Project administration, Writing—original draft, review, and editing1⇑ and
  7. Michael J Clague, Conceptualization, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing1⇑
  1. 1Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
  2. 2Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK
  1. Correspondence: urbe{at}liv.ac.uk
  2. clague{at}liv.ac.uk
  1. ↵* Emma V Rusilowicz-Jones and Francesco G Barone contributed equally to this work

View Full Text

Funding

  • Wellcome Trust

    102172/B/13/Z
    FG Barone
  • Bristol Myers Squibb and Celgene

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Benchmarking a USP30 inhibitor
Emma V Rusilowicz-Jones, Francesco G Barone, Fernanda Martins Lopes, Elezabeth Stephen, Heather Mortiboys, Sylvie Urbé, Michael J Clague
Life Science Alliance Nov 2021, 5 (2) e202101287; DOI: 10.26508/lsa.202101287

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Benchmarking a USP30 inhibitor
Emma V Rusilowicz-Jones, Francesco G Barone, Fernanda Martins Lopes, Elezabeth Stephen, Heather Mortiboys, Sylvie Urbé, Michael J Clague
Life Science Alliance Nov 2021, 5 (2) e202101287; DOI: 10.26508/lsa.202101287
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Volume 5, No. 2
February 2022
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