TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses

Yusuke Miyashita; Takahisa Kouwaki; Hirotake Tsukamoto; Masaaki Okamoto; Kimitoshi Nakamura; Hiroyuki Oshiumi

doi:10.26508/lsa.202101181

Research Article

Open Access

TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses

View ORCID ProfileYusuke Miyashita, Takahisa Kouwaki, View ORCID ProfileHirotake Tsukamoto Correspondence email, View ORCID ProfileMasaaki Okamoto, View ORCID ProfileKimitoshi Nakamura, View ORCID ProfileHiroyuki Oshiumi Correspondence email

Yusuke Miyashita

1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

Roles: Data curation, Formal analysis, Validation, Investigation, Writing—original draft, review, and editing

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ORCID record for Yusuke Miyashita

Takahisa Kouwaki

1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

Roles: Data curation, Investigation

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Hirotake Tsukamoto

1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

3Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Roles: Data curation, Supervision, Investigation, Writing—original draft, review, and editing

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ORCID record for Hirotake Tsukamoto
For correspondence: tsukamoto.hirotake.4j@kyoto-u.ac.jp

Masaaki Okamoto

1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

Roles: Data curation, Investigation

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ORCID record for Masaaki Okamoto

Kimitoshi Nakamura

2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

Roles: Conceptualization, Supervision, Project administration

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ORCID record for Kimitoshi Nakamura

Hiroyuki Oshiumi

1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing

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ORCID record for Hiroyuki Oshiumi
For correspondence: oshiumi@kumamoto-u.ac.jp

Published 24 November 2021. DOI: 10.26508/lsa.202101181

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TICAM-1 is a negative regulator of IL-17RA signaling