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Research Article
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TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses

View ORCID ProfileYusuke Miyashita, Takahisa Kouwaki, View ORCID ProfileHirotake Tsukamoto  Correspondence email, View ORCID ProfileMasaaki Okamoto, View ORCID ProfileKimitoshi Nakamura, View ORCID ProfileHiroyuki Oshiumi  Correspondence email
Yusuke Miyashita
1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
Roles: Data curation, Formal analysis, Validation, Investigation, Writing—original draft, review, and editing
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  • ORCID record for Yusuke Miyashita
Takahisa Kouwaki
1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
Roles: Data curation, Investigation
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Hirotake Tsukamoto
1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
3Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Roles: Data curation, Supervision, Investigation, Writing—original draft, review, and editing
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  • ORCID record for Hirotake Tsukamoto
  • For correspondence: tsukamoto.hirotake.4j@kyoto-u.ac.jp
Masaaki Okamoto
1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
Roles: Data curation, Investigation
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  • ORCID record for Masaaki Okamoto
Kimitoshi Nakamura
2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
Roles: Conceptualization, Supervision, Project administration
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  • ORCID record for Kimitoshi Nakamura
Hiroyuki Oshiumi
1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Hiroyuki Oshiumi
  • For correspondence: oshiumi@kumamoto-u.ac.jp
Published 24 November 2021. DOI: 10.26508/lsa.202101181
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Article Information

vol. 5 no. 2 e202101181
DOI 
https://doi.org/10.26508/lsa.202101181
PubMed 
34819358

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received July 30, 2021
  • Revision received November 12, 2021
  • Accepted November 12, 2021
  • Published online November 24, 2021.

Copyright & Usage 
© 2021 Miyashita et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Yusuke Miyashita, Data curation, Formal analysis, Validation, Investigation, Writing—original draft, review, and editing1,2,
  2. Takahisa Kouwaki, Data curation, Investigation1,
  3. Hirotake Tsukamoto, Data curation, Supervision, Investigation, Writing—original draft, review, and editing1,3⇑,
  4. Masaaki Okamoto, Data curation, Investigation1,
  5. Kimitoshi Nakamura, Conceptualization, Supervision, Project administration2 and
  6. Hiroyuki Oshiumi, Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing1⇑
  1. 1Department of Immunology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
  2. 2Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan
  3. 3Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  1. Correspondence: oshiumi{at}kumamoto-u.ac.jp
  2. tsukamoto.hirotake.4j{at}kyoto-u.ac.jp
View Full Text

Funding

  • Japan Society for the Promotion of Science (JSPS) KAKENHI

    JPH03480 and 19H03480
  • Japan Agency for Medical Research and Development

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TICAM-1 is a negative regulator of IL-17RA signaling
Yusuke Miyashita, Takahisa Kouwaki, Hirotake Tsukamoto, Masaaki Okamoto, Kimitoshi Nakamura, Hiroyuki Oshiumi
Life Science Alliance Nov 2021, 5 (2) e202101181; DOI: 10.26508/lsa.202101181

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TICAM-1 is a negative regulator of IL-17RA signaling
Yusuke Miyashita, Takahisa Kouwaki, Hirotake Tsukamoto, Masaaki Okamoto, Kimitoshi Nakamura, Hiroyuki Oshiumi
Life Science Alliance Nov 2021, 5 (2) e202101181; DOI: 10.26508/lsa.202101181
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Volume 5, No. 2
February 2022
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