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Research Articles
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylationInactivation of N-terminal acetyltransferase A is found to alter Rpn4 as well as E3 ligase abundance, causing up-regulation of Ubiquitin–proteasome activity. In this context, Tom1 is also identified as a novel chain-elongating enzyme of the UFD-pathway.
The different activities of RNA G-quadruplex structures are controlled by flanking sequencesThis study demonstrates the dynamic and multifunctional aspects of RNA G4 structures.
Serine palmitoyltransferase assembles at ER–mitochondria contact sitesSPTLC2 localizes to the ER and mitochondria where it interacts with ER-localized SPTLC1 to form the sphingolipid-synthesizing enzyme serine palmitoyltransferase at the ER and ER–mitochondria contact sites.
Chromosome length and gene density contribute to micronuclear membrane stabilityChromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulseThe authors characterize the growth condition dependence of survival of bacteria exposed to lethal antibiotics for a week. 1-h starvation pulse is shown to cause an increase in survival for days.
Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distressVaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesisTumor axonogenesis is an emerging hallmark of cancer and TGF-beta is a well-known cytokine involved in the control of cancer progression. In this study we identify a novel function for the TGF-beta signaling in cancer aggressivity by promoting cancer axonogenesis.
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochleaThe authors show in the mouse how the auditory hair cell structural maintenance is perturbed by the inactivation of Manf and the concomitant ER stress, causing early-onset, progressive hearing loss.
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switchingTGFβ, YAP/TAZ, and canonical Wnt/β-catenin signaling functionally interact in a hierarchical manner to induce the switching of melanoma cells from proliferative-to-invasive cell phenotype.
TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregationDiffuse alveolar hemorrhage developed in an SLE mouse model is ameliorated by TANK via the suppression of type I IFN induced by cGAS-mediated sensing of intracellular DNA.
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responsesTICAM-1/TRIF, a TLR3 adaptor molecule, associates with Act1 to inhibit the interaction between IL-17RA and Act1, resulting in attenuated IL-17-mediated inflammatory responses.
Temporal and sequential order of nonoverlapping gene networks unraveled in mated female DrosophilaMating triggers successive waves of temporal transcriptomic changes within independent gene networks in female Drosophila, suggesting a recruitment of interconnected modules that vanish in late life.
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagyA detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy.
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasmaUsing microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.
RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress responseComparative RNA interactome capture identifies potential regulators of RNA metabolism in fission yeast and reveals RNA exosome–dependent buffering of stress-responsive gene expression networks.
