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Table of Contents

February 2022 | Volume 5, No. 2

Research Articles

  • Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation
    Open Access
    Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation

    Ilia Kats, Christian Reinbold, Marc Kschonsak, Anton Khmelinskii, Laura Armbruster, Thomas Ruppert, Michael Knop

    Ilia Kats ... Michael Knop

    Published 11 November 2021

    Inactivation of N-terminal acetyltransferase A is found to alter Rpn4 as well as E3 ligase abundance, causing up-regulation of Ubiquitin–proteasome activity. In this context, Tom1 is also identified as a novel chain-elongating enzyme of the UFD-pathway.

  • The different activities of RNA G-quadruplex structures are controlled by flanking sequences
    Open Access
    The different activities of RNA G-quadruplex structures are controlled by flanking sequences

    Alice J-L Zheng, Aikaterini Thermou, Pedro Guixens Gallardo, Laurence Malbert-Colas, Chrysoula Daskalogianni, Nathan Vaudiau, Petter Brohagen, Anton Granzhan, Marc Blondel, Marie-Paule Teulade-Fichou, Rodrigo Prado Martins, Robin Fahraeus

    Alice J-L Zheng ... Robin Fahraeus

    Published 16 November 2021

    This study demonstrates the dynamic and multifunctional aspects of RNA G4 structures.

  • Serine palmitoyltransferase assembles at ER–mitochondria contact sites
    Open Access
    Serine palmitoyltransferase assembles at ER–mitochondria contact sites

    Mari J Aaltonen, Irina Alecu, Tim König, Steffany AL Bennett, Eric A Shoubridge

    Mari J Aaltonen ... Eric A Shoubridge

    Published 16 November 2021

    SPTLC2 localizes to the ER and mitochondria where it interacts with ER-localized SPTLC1 to form the sphingolipid-synthesizing enzyme serine palmitoyltransferase at the ER and ER–mitochondria contact sites.

  • Chromosome length and gene density contribute to micronuclear membrane stability
    Open Access
    Chromosome length and gene density contribute to micronuclear membrane stability

    Anna E Mammel, Heather Z Huang, Amanda L Gunn, Emma Choo, Emily M Hatch

    Anna E Mammel ... Emily M Hatch

    Published 17 November 2021

    Chromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.

  • Existence of log-phase <em>Escherichia coli</em> persisters and lasting memory of a starvation pulse
    Open Access
    Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulse

    Mikkel Skjoldan Svenningsen, Sine Lo Svenningsen, Michael Askvad Sørensen, Namiko Mitarai

    Mikkel Skjoldan Svenningsen ... Namiko Mitarai

    Published 18 November 2021

    The authors characterize the growth condition dependence of survival of bacteria exposed to lethal antibiotics for a week. 1-h starvation pulse is shown to cause an increase in survival for days.

  • Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
    Open Access
    Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress

    Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A Sussman

    Carolina Esquer ... Mark A Sussman

    Published 22 November 2021

    Vaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.

  • TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis
    Open Access
    TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis

    Simon Grelet, Cécile Fréreux, Clémence Obellianne, Ken Noguchi, Breege V Howley, Annamarie C Dalton, Philip H Howe

    Simon Grelet ... Philip H Howe

    Published 22 November 2021

    Tumor axonogenesis is an emerging hallmark of cancer and TGF-beta is a well-known cytokine involved in the control of cancer progression. In this study we identify a novel function for the TGF-beta signaling in cancer aggressivity by promoting cancer axonogenesis.

  • MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea
    Open Access
    MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea

    Kuu Ikäheimo, Anni Herranen, Vilma Iivanainen, Tuuli Lankinen, Antti A Aarnisalo, Ville Sivonen, Kashyap A Patel, Korcan Demir, Mart Saarma, Maria Lindahl, Ulla Pirvola

    Kuu Ikäheimo ... Ulla Pirvola

    Published 23 November 2021

    The authors show in the mouse how the auditory hair cell structural maintenance is perturbed by the inactivation of Manf and the concomitant ER stress, causing early-onset, progressive hearing loss.

  • Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching
    Open Access
    Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching

    Fabiana Lüönd, Martin Pirkl, Mizue Hisano, Vincenzo Prestigiacomo, Ravi KR Kalathur, Niko Beerenwinkel, Gerhard Christofori

    Fabiana Lüönd ... Gerhard Christofori

    Published 24 November 2021

    TGFβ, YAP/TAZ, and canonical Wnt/β-catenin signaling functionally interact in a hierarchical manner to induce the switching of melanoma cells from proliferative-to-invasive cell phenotype.

  • TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation
    Open Access
    TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation

    Atsuko Wakabayashi, Masanori Yoshinaga, Osamu Takeuchi

    Atsuko Wakabayashi ... Osamu Takeuchi

    Published 24 November 2021

    Diffuse alveolar hemorrhage developed in an SLE mouse model is ameliorated by TANK via the suppression of type I IFN induced by cGAS-mediated sensing of intracellular DNA.

  • TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses
    Open Access
    TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses

    Yusuke Miyashita, Takahisa Kouwaki, Hirotake Tsukamoto, Masaaki Okamoto, Kimitoshi Nakamura, Hiroyuki Oshiumi

    Yusuke Miyashita ... Hiroyuki Oshiumi

    Published 24 November 2021

    TICAM-1/TRIF, a TLR3 adaptor molecule, associates with Act1 to inhibit the interaction between IL-17RA and Act1, resulting in attenuated IL-17-mediated inflammatory responses.

  • Temporal and sequential order of nonoverlapping gene networks unraveled in mated female Drosophila
    Open Access
    Temporal and sequential order of nonoverlapping gene networks unraveled in mated female Drosophila

    Claude Pasquier, Alain Robichon

    Claude Pasquier ... Alain Robichon

    Published 29 November 2021

    Mating triggers successive waves of temporal transcriptomic changes within independent gene networks in female Drosophila, suggesting a recruitment of interconnected modules that vanish in late life.

  • Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy
    Open Access
    Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy

    Emma V Rusilowicz-Jones, Francesco G Barone, Fernanda Martins Lopes, Elezabeth Stephen, Heather Mortiboys, Sylvie Urbé, Michael J Clague

    Emma V Rusilowicz-Jones ... Michael J Clague

    Published 29 November 2021

    A detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy.

  • Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
    Open Access
    Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

    Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado Morales, Georg Meisl, Priscilla Turelli, Chryssa Zografou, Manuela R Zimmermann, Beat M Frey, Sebastian Fiedler, Viola Denninger, Raphaël PB Jacquat, Lidia Madrigal, Alison Ilsley, Vasilis Kosmoliaptsis, Heike Fiegler, Didier Trono, Tuomas PJ Knowles, Adriano Aguzzi

    Matthias M Schneider ... Adriano Aguzzi

    Published 30 November 2021

    Using microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.

  • RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response
    Open Access
    RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response

    Adrien Birot, Krzysztof Kus, Emily Priest, Ahmad Al Alwash, Alfredo Castello, Shabaz Mohammed, Lidia Vasiljeva, Cornelia Kilchert

    Adrien Birot ... Cornelia Kilchert

    Published 30 November 2021

    Comparative RNA interactome capture identifies potential regulators of RNA metabolism in fission yeast and reveals RNA exosome–dependent buffering of stress-responsive gene expression networks.

Corrections

  • Open Access
    Correction: A brain-specific PGC1a fusion transcript affects gene expression and behavioral outcomes in mice

    Oswaldo A Lozoya, Fuhua Xu, Dagoberto Grenet, Tianyuan Wang, Korey D Stevanovic, Jesse D Cushman, Thomas B Hagler, Artiom Gruzdev, Patricia Jensen, Bairon Hernandez, Gonzalo Riadi, Sheryl S Moy, Janine H Santos, Richard P Woychik

    Oswaldo A Lozoya ... Richard P Woychik

    Published 24 November 2021
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Volume 5, No. 2
February 2022
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