RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability

Kristin Gehling; Swati Parekh; Farina Schneider; Marcel Kirchner; Vangelis Kondylis; Chrysa Nikopoulou; Peter Tessarz

doi:10.26508/lsa.202101340

Research Article

Open Access

RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability

View ORCID ProfileKristin Gehling, View ORCID ProfileSwati Parekh, Farina Schneider, Marcel Kirchner, View ORCID ProfileVangelis Kondylis, View ORCID ProfileChrysa Nikopoulou Correspondence email, View ORCID ProfilePeter Tessarz Correspondence email

Kristin Gehling

1Max Planck Research Group “Chromatin and Ageing,” Max Planck Institute for Biology of Ageing, Cologne, Germany

2Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany

Roles: Formal analysis, Investigation, Methodology

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ORCID record for Kristin Gehling

Swati Parekh

1Max Planck Research Group “Chromatin and Ageing,” Max Planck Institute for Biology of Ageing, Cologne, Germany

Roles: Formal analysis

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ORCID record for Swati Parekh

Farina Schneider

3Institute for Pathology, University Hospital Cologne, Cologne, Germany

Roles: Investigation

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Marcel Kirchner

4FACS and Imaging Core Facility, Max Planck Institute for Biology of Ageing, Cologne, Germany

Roles: Software, Visualization

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Vangelis Kondylis

3Institute for Pathology, University Hospital Cologne, Cologne, Germany

Roles: Investigation, Methodology

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ORCID record for Vangelis Kondylis

Chrysa Nikopoulou

1Max Planck Research Group “Chromatin and Ageing,” Max Planck Institute for Biology of Ageing, Cologne, Germany

Roles: Conceptualization, Supervision, Investigation, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Chrysa Nikopoulou
For correspondence: cnikopoulou@age.mpg.de ptessarz@age.mpg.de

Peter Tessarz

1Max Planck Research Group “Chromatin and Ageing,” Max Planck Institute for Biology of Ageing, Cologne, Germany

2Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany

Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—original draft, review, and editing

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ORCID record for Peter Tessarz
For correspondence: cnikopoulou@age.mpg.de ptessarz@age.mpg.de

Published 1 August 2022. DOI: 10.26508/lsa.202101340

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Organoid-to-organoid heterogeneity

Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz

Life Science Alliance Aug 2022, 5 (12) e202101340; DOI: 10.26508/lsa.202101340

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Organoid-to-organoid heterogeneity

Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz

Life Science Alliance Aug 2022, 5 (12) e202101340; DOI: 10.26508/lsa.202101340

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December 2022

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