Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

Victoria L Hewitt; Leonor Miller-Fleming; Madeleine J Twyning; Simonetta Andreazza; Francesca Mattedi; Julien Prudent; Franck Polleux; Alessio Vagnoni; Alexander J Whitworth

doi:10.26508/lsa.202201531

Research Article

Open Access

Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ₄₂ toxicity

View ORCID ProfileVictoria L Hewitt, View ORCID ProfileLeonor Miller-Fleming, View ORCID ProfileMadeleine J Twyning, View ORCID ProfileSimonetta Andreazza, View ORCID ProfileFrancesca Mattedi, View ORCID ProfileJulien Prudent, View ORCID ProfileFranck Polleux, View ORCID ProfileAlessio Vagnoni, View ORCID ProfileAlexander J Whitworth Correspondence email

Victoria L Hewitt

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

2Department of Neuroscience, Columbia University Medical Center, New York, NY, USA

Roles: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft, review, and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Victoria L Hewitt

Leonor Miller-Fleming

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Leonor Miller-Fleming

Madeleine J Twyning

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Roles: Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Madeleine J Twyning

Simonetta Andreazza

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Roles: Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Simonetta Andreazza

Francesca Mattedi

3Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, IoPPN, King’s College London, London, UK

Roles: Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Francesca Mattedi

Julien Prudent

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Roles: Supervision, Funding acquisition, Investigation, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Julien Prudent

Franck Polleux

2Department of Neuroscience, Columbia University Medical Center, New York, NY, USA

4Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, USA

5Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY, USA

Roles: Supervision, Funding acquisition, Investigation, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Franck Polleux

Alessio Vagnoni

3Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, IoPPN, King’s College London, London, UK

Roles: Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing—review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alessio Vagnoni

Alexander J Whitworth

1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Writing—original draft, review, and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alexander J Whitworth
For correspondence: a.whitworth@mrc-mbu.cam.ac.uk

Published 13 July 2022. DOI: 10.26508/lsa.202201531

Article
Figures & Data
Info
Metrics
Reviewer Comments
PDF

You are using an old browser, click here to download PDF

PDF Container

PreviousNext

Download PDF

Email Article

Thank you for your interest in spreading the word on Life Science Alliance.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

Message Subject (Your Name) has sent you a message from Life Science Alliance

Message Body (Your Name) thought you would like to see the Life Science Alliance web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Citation Tools

Impact of pdzd8 on organismal fitness and Aβ₄₂ toxicity

Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth

Life Science Alliance Jul 2022, 5 (11) e202201531; DOI: 10.26508/lsa.202201531

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Impact of pdzd8 on organismal fitness and Aβ₄₂ toxicity

Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth

Life Science Alliance Jul 2022, 5 (11) e202201531; DOI: 10.26508/lsa.202201531

Share This Article:

Tweet Widget
Facebook Like

In this Issue

Volume 5, No. 11

November 2022

Table of Contents
Cover (PDF)
About the Cover
Masthead (PDF)

Jump to section

Article
Figures & Data
Info
Metrics
Reviewer Comments
PDF

No related articles found.

Cited By...

No citing articles found.

Google Scholar

Main menu

User menu

Search

Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ₄₂ toxicity

Citation Manager Formats

In this Issue

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Content

For Authors

Other Services

More Information