Advertisement
Research Article
Transparent Process
Open Access

Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth  Correspondence email
Published 13 July 2022. DOI: 10.26508/lsa.202201531

Article Information

vol. 5 no. 11 e202201531
DOI 
https://doi.org/10.26508/lsa.202201531
PubMed 
35831024
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 24, 2022
  • Revision received July 1, 2022
  • Accepted July 1, 2022
  • Published online July 13, 2022.
Copyright & Usage 
© 2022 Hewitt et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Victoria L Hewitt, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft, review, and editing1,2,
  2. Leonor Miller-Fleming1,
  3. Madeleine J Twyning, Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing1,
  4. Simonetta Andreazza, Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing1,
  5. Francesca Mattedi, Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing3,
  6. Julien Prudent, Supervision, Funding acquisition, Investigation, Writing—review and editing1,
  7. Franck Polleux, Supervision, Funding acquisition, Investigation, Writing—review and editing2,4,5,
  8. Alessio Vagnoni, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing—review and editing3 and
  9. Alexander J Whitworth, Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Writing—original draft, review, and editing1⇑
  1. 1Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK
  2. 2Department of Neuroscience, Columbia University Medical Center, New York, NY, USA
  3. 3Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, IoPPN, King’s College London, London, UK
  4. 4Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, USA
  5. 5Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY, USA
  1. Correspondence: a.whitworth{at}mrc-mbu.cam.ac.uk
View Full Text

Funding

  • NIH

    P40OD018537

  • Medical Research Council

    MC_UU_00015/6; MC_UU_00028/6
    AJ Whitworth

  • Medical Research Council

    MC_UU_00015/7; MC_UU_00028/5
    J Prudent

  • European Research Council

    309742
    AJ Whitworth

  • Skills and Knowledge Transfer

    N/N001753/2; NC/T001224/1

  • Academy of Medical Sciences Springboard Award

    SBF004/1088

  • EMBO

    ALTF 740-2015
    VL Hewitt

  • European Commission FP7

    GA-2013-609409
Back to top
Download PDF
Email Article
Citation Tools
Impact of pdzd8 on organismal fitness and Aβ42 toxicity
Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth
Life Science Alliance Jul 2022, 5 (11) e202201531; DOI: 10.26508/lsa.202201531
Reddit logo Twitter logo Facebook logo Mendeley logo
Issue Cover

In this Issue

Volume 5, No. 11
November 2022
Advertisement

Jump to section