Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior

Carla Igual Gil; Bethany M Coull; Wenke Jonas; Rachel N Lippert; Susanne Klaus; Mario Ost

doi:10.26508/lsa.202201495

Research Article

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Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior

View ORCID ProfileCarla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, View ORCID ProfileSusanne Klaus Correspondence email, View ORCID ProfileMario Ost Correspondence email

Carla Igual Gil

1Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

2Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

Roles: Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Carla Igual Gil

Bethany M Coull

3Department of Neurocircuit Development and Function, German Institute of Human Nutrition, Nuthetal, Germany

7NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany

Roles: Investigation, Writing—review and editing

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Wenke Jonas

4Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

5German Center for Diabetes Research, München-Neuherberg, Germany

Roles: Methodology

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Rachel N Lippert

3Department of Neurocircuit Development and Function, German Institute of Human Nutrition, Nuthetal, Germany

5German Center for Diabetes Research, München-Neuherberg, Germany

7NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Berlin, Germany

Roles: Validation, Investigation, Writing—review and editing

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Susanne Klaus

1Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

2Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

Roles: Conceptualization, Supervision, Funding acquisition, Writing—review and editing

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ORCID record for Susanne Klaus
For correspondence: Mario.Ost@dife.de klaus@dife.de

Mario Ost

1Department of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany

6Department of Molecular Nutritional Physiology, Friedrich Schiller University Jena, Jena, Germany

Roles: Conceptualization, Formal analysis, Supervision, Validation, Investigation, Visualization, Project administration, Writing—original draft, review, and editing

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ORCID record for Mario Ost
For correspondence: Mario.Ost@dife.de klaus@dife.de

Published 6 September 2022. DOI: 10.26508/lsa.202201495

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Muscle–brain crosstalk via the GDF15-GFRAL axis

Carla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, Susanne Klaus, Mario Ost

Life Science Alliance Sep 2022, 5 (11) e202201495; DOI: 10.26508/lsa.202201495

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Muscle–brain crosstalk via the GDF15-GFRAL axis

Carla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, Susanne Klaus, Mario Ost

Life Science Alliance Sep 2022, 5 (11) e202201495; DOI: 10.26508/lsa.202201495

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