STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

Julia E Lefler; Catherine B MarElia-Bennett; Katie A Thies; Blake E Hildreth; Sudarshana M Sharma; Jason R Pitarresi; Lu Han; Caroline Everett; Christopher Koivisto; Maria C Cuitino; Cynthia D Timmers; Elizabeth O’Quinn; Melodie Parrish; Martin J Romeo; Amanda J Linke; G Aaron Hobbs; Gustavo Leone; Denis C Guttridge; Teresa A Zimmers; Gregory B Lesinski; Michael C Ostrowski

doi:10.26508/lsa.202201460

Research Article

Open Access

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

Julia E Lefler, View ORCID ProfileCatherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Jason R Pitarresi, Lu Han, View ORCID ProfileCaroline Everett, Christopher Koivisto, Maria C Cuitino, Cynthia D Timmers, Elizabeth O’Quinn, Melodie Parrish, Martin J Romeo, Amanda J Linke, G Aaron Hobbs, Gustavo Leone, Denis C Guttridge, Teresa A Zimmers, Gregory B Lesinski, View ORCID ProfileMichael C Ostrowski Correspondence email

Julia E Lefler

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Conceptualization, Data curation, Formal analysis, Investigation, Writing—original draft, review, and editing

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Catherine B MarElia-Bennett

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Data curation, Formal analysis, Investigation, Writing—original draft, review, and editing

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ORCID record for Catherine B MarElia-Bennett

Katie A Thies

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Blake E Hildreth III

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Sudarshana M Sharma

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Methodology, Writing—review and editing

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Jason R Pitarresi

2Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

Roles: Writing—review and editing

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Lu Han

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Caroline Everett

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Data curation, Writing—review and editing

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ORCID record for Caroline Everett

Christopher Koivisto

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Maria C Cuitino

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Methodology, Writing—review and editing

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Cynthia D Timmers

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Methodology, Writing—review and editing

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Elizabeth O’Quinn

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Melodie Parrish

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Methodology, Writing—review and editing

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Martin J Romeo

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Amanda J Linke

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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G Aaron Hobbs

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Gustavo Leone

3Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA

Roles: Writing—review and editing

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Denis C Guttridge

4Department of Pediatrics and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA

Roles: Writing—review and editing

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Teresa A Zimmers

5Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA

Roles: Writing—review and editing

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Gregory B Lesinski

6Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA

Roles: Writing—review and editing

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Michael C Ostrowski

1Hollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

Roles: Conceptualization, Data curation, Writing—original draft, review, and editing

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ORCID record for Michael C Ostrowski
For correspondence: ostrowsk@musc.edu

Published 8 July 2022. DOI: 10.26508/lsa.202201460

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STAT3 in CAFs promotes immunosuppression PDAC

Julia E Lefler, Catherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Jason R Pitarresi, Lu Han, Caroline Everett, Christopher Koivisto, Maria C Cuitino, Cynthia D Timmers, Elizabeth O’Quinn, Melodie Parrish, Martin J Romeo, Amanda J Linke, G Aaron Hobbs, Gustavo Leone, Denis C Guttridge, Teresa A Zimmers, Gregory B Lesinski, Michael C Ostrowski

Life Science Alliance Jul 2022, 5 (11) e202201460; DOI: 10.26508/lsa.202201460

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STAT3 in CAFs promotes immunosuppression PDAC

Life Science Alliance Jul 2022, 5 (11) e202201460; DOI: 10.26508/lsa.202201460

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