Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants

Laura Strohm; Zehan Hu; Yongwon Suk; Alina Rühmkorf; Erin Sternburg; Vanessa Gattringer; Henrick Riemenschneider; Riccardo Berutti; Elisabeth Graf; Jochen H Weishaupt; Monika S Brill; Angelika B Harbauer; Dorothee Dormann; Jörn Dengjel; Dieter Edbauer; Christian Behrends

doi:10.26508/lsa.202101327

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Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants

View ORCID ProfileLaura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, View ORCID ProfileMonika S Brill, View ORCID ProfileAngelika B Harbauer, View ORCID ProfileDorothee Dormann, Jörn Dengjel, Dieter Edbauer, View ORCID ProfileChristian Behrends Correspondence email

Laura Strohm

1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany

Roles: Conceptualization, Data curation, Validation, Investigation, Visualization, Methodology, Writing—original draft, review, and editing

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Zehan Hu

3Department of Biology, University of Fribourg, Fribourg, Switzerland

Roles: Data curation, Investigation, Methodology

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Yongwon Suk

4Institute for Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany

Roles: Investigation

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Alina Rühmkorf

10Max Planck Institute of Neurobiology, Martinsried, Germany

Roles: Investigation

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Erin Sternburg

4Institute for Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany

Roles: Data curation

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Vanessa Gattringer

1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany

Roles: Investigation

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Henrick Riemenschneider

1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany

2German Center for Neurodegenerative Diseases Munich, Munich, Germany

Roles: Investigation

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Riccardo Berutti

8Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany

Roles: Data curation, Investigation, Methodology

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Elisabeth Graf

7Institut für Humangenetik, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany

Roles: Data curation, Investigation, Methodology

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Jochen H Weishaupt

6Division of Neurodegenerative Disorders, Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany

Roles: Resources

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Monika S Brill

11Munich Cluster for Systems Neurology, Munich, Germany

12Institute of Neuronal Cell Biology, Technische Universität München, Munich, Germany

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Angelika B Harbauer

9Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany

10Max Planck Institute of Neurobiology, Martinsried, Germany

11Munich Cluster for Systems Neurology, Munich, Germany

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Dorothee Dormann

4Institute for Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany

5Institute of Molecule Biology, Mainz, Germany

Roles: Resources, Validation

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Jörn Dengjel

3Department of Biology, University of Fribourg, Fribourg, Switzerland

Roles: Resources, Investigation, Methodology

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Dieter Edbauer

1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany

2German Center for Neurodegenerative Diseases Munich, Munich, Germany

Roles: Resources, Methodology

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Christian Behrends

1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-University München, Munich, Germany

Roles: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Validation, Visualization, Project administration, Writing—original draft, review, and editing

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ORCID record for Christian Behrends
For correspondence: christian.behrends@mail03.med.uni-muenchen.de

Published 1 July 2022. DOI: 10.26508/lsa.202101327

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UBQLN2-dependent alterations

Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, Monika S Brill, Angelika B Harbauer, Dorothee Dormann, Jörn Dengjel, Dieter Edbauer, Christian Behrends

Life Science Alliance Jul 2022, 5 (11) e202101327; DOI: 10.26508/lsa.202101327

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UBQLN2-dependent alterations

Life Science Alliance Jul 2022, 5 (11) e202101327; DOI: 10.26508/lsa.202101327

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Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants

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