Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension

Jonathan Florentin; Jingsi Zhao; Yi-Yin Tai; Wei Sun; Lee L Ohayon; Scott P O’Neil; Anagha Arunkumar; Xinyi Zhang; Jianhui Zhu; Yassmin Al Aaraj; Annie Watson; John Sembrat; Mauricio Rojas; Stephen Y Chan; Partha Dutta

doi:10.26508/lsa.202101264

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Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension

Jonathan Florentin, Jingsi Zhao, Yi-Yin Tai, Wei Sun, Lee L Ohayon, Scott P O’Neil, Anagha Arunkumar, View ORCID ProfileXinyi Zhang, View ORCID ProfileJianhui Zhu, Yassmin Al Aaraj, Annie Watson, John Sembrat, Mauricio Rojas, View ORCID ProfileStephen Y Chan Correspondence email, View ORCID ProfilePartha Dutta Correspondence email

Jonathan Florentin

1Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Roles: Conceptualization, Data curation, Formal analysis, Investigation, Writing—original draft, review, and editing

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Jingsi Zhao

Roles: Data curation

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Yi-Yin Tai

Roles: Data curation

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Wei Sun

Roles: Data curation

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Lee L Ohayon

Roles: Data curation

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Scott P O’Neil

Roles: Data curation

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Anagha Arunkumar

Roles: Data curation

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Xinyi Zhang

Roles: Data curation

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Jianhui Zhu

3Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA

Roles: Methodology

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Yassmin Al Aaraj

Roles: Resources

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Annie Watson

Roles: Resources

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John Sembrat

2Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA

Roles: Resources

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Mauricio Rojas

2Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA

Roles: Resources

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Stephen Y Chan

Roles: Resources, Funding acquisition, Writing—review and editing

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For correspondence: duttapa@pitt.edu chansy@pitt.edu

Partha Dutta

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing

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For correspondence: duttapa@pitt.edu chansy@pitt.edu

Published 22 June 2022. DOI: 10.26508/lsa.202101264

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AREG promotes endothelial cell survival in PH

Jonathan Florentin, Jingsi Zhao, Yi-Yin Tai, Wei Sun, Lee L Ohayon, Scott P O’Neil, Anagha Arunkumar, Xinyi Zhang, Jianhui Zhu, Yassmin Al Aaraj, Annie Watson, John Sembrat, Mauricio Rojas, Stephen Y Chan, Partha Dutta

Life Science Alliance Jun 2022, 5 (11) e202101264; DOI: 10.26508/lsa.202101264

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AREG promotes endothelial cell survival in PH

Life Science Alliance Jun 2022, 5 (11) e202101264; DOI: 10.26508/lsa.202101264

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