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Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension

Jonathan Florentin, Jingsi Zhao, Yi-Yin Tai, Wei Sun, Lee L Ohayon, Scott P O’Neil, Anagha Arunkumar, Xinyi Zhang, Jianhui Zhu, Yassmin Al Aaraj, Annie Watson, John Sembrat, Mauricio Rojas, Stephen Y Chan  Correspondence email, Partha Dutta  Correspondence email
Published 22 June 2022. DOI: 10.26508/lsa.202101264

Article Information

vol. 5 no. 11 e202101264
DOI 
https://doi.org/10.26508/lsa.202101264
PubMed 
35732465
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received October 19, 2021
  • Revision received June 9, 2022
  • Accepted June 9, 2022
  • Published online June 22, 2022.
Copyright & Usage 
© 2022 Florentin et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Jonathan Florentin, Conceptualization, Data curation, Formal analysis, Investigation, Writing—original draft, review, and editing1,
  2. Jingsi Zhao, Data curation1,
  3. Yi-Yin Tai, Data curation1,
  4. Wei Sun, Data curation1,
  5. Lee L Ohayon, Data curation1,
  6. Scott P O’Neil, Data curation1,
  7. Anagha Arunkumar, Data curation1,
  8. Xinyi Zhang, Data curation1,
  9. Jianhui Zhu, Methodology3,
  10. Yassmin Al Aaraj, Resources1,
  11. Annie Watson, Resources1,
  12. John Sembrat, Resources1,2,
  13. Mauricio Rojas, Resources1,2,
  14. Stephen Y Chan, Resources, Funding acquisition, Writing—review and editing1,*⇑ and
  15. Partha Dutta, Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing1,4,*⇑
  1. 1Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
  2. 2Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  3. 3Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
  4. 4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  1. Correspondence: duttapa{at}pitt.edu; chansy{at}pitt.edu

  1. ↵* Stephen Y Chan and Partha Dutta contributed equally to this work.

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Funding

  • National Institute of Health

    R00HL121076-03; R01HL143967; R01HL142629; R01AG069399
    P Dutta

  • AHA Transformational Project Award

    19TPA34910142
    P Dutta

  • AHA Innovative Project Award

    19IPLOI34760566
    P Dutta

  • ALA Innovation Project Award

    IA-629694
    P Dutta

  • National, Heart, Lung and Blood Institute

    J Florentin

  • NIH

    R01 HL124021; HL 122596

  • American Heart Association Established Investigator Award

    18EIA33900027
    SY Chan

  • NIH

    1S10OD019973-01
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AREG promotes endothelial cell survival in PH
Jonathan Florentin, Jingsi Zhao, Yi-Yin Tai, Wei Sun, Lee L Ohayon, Scott P O’Neil, Anagha Arunkumar, Xinyi Zhang, Jianhui Zhu, Yassmin Al Aaraj, Annie Watson, John Sembrat, Mauricio Rojas, Stephen Y Chan, Partha Dutta
Life Science Alliance Jun 2022, 5 (11) e202101264; DOI: 10.26508/lsa.202101264
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Volume 5, No. 11
November 2022
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