Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

David Romano; Lucía García-Gutiérrez; Nourhan Aboud; David J Duffy; Keith T Flaherty; Dennie T Frederick; Walter Kolch; David Matallanas

doi:10.26508/lsa.202201445

Research Article

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Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

David Romano, View ORCID ProfileLucía García-Gutiérrez, View ORCID ProfileNourhan Aboud, View ORCID ProfileDavid J Duffy, View ORCID ProfileKeith T Flaherty, Dennie T Frederick, View ORCID ProfileWalter Kolch Correspondence email, View ORCID ProfileDavid Matallanas Correspondence email

David Romano

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

Roles: Conceptualization, Data curation, Formal analysis, Investigation, Writing—review and editing

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Lucía García-Gutiérrez

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

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ORCID record for Lucía García-Gutiérrez

Nourhan Aboud

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

Roles: Investigation

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ORCID record for Nourhan Aboud

David J Duffy

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

4Department of Biology/Whitney Laboratory for Marine Bioscience, University of Florida, Gainesville, FL, USA

Roles: Data curation, Investigation, Writing—review and editing

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ORCID record for David J Duffy

Keith T Flaherty

3Massachusetts General Hospital, Boston, MA, USA

Roles: Data curation, Investigation, Writing—review and editing

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ORCID record for Keith T Flaherty

Dennie T Frederick

3Massachusetts General Hospital, Boston, MA, USA

Roles: Data curation, Investigation, Writing—review and editing

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Walter Kolch

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

2Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

Roles: Conceptualization, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing

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ORCID record for Walter Kolch
For correspondence: david.gomez@ucd.ie walter.kolch@ucd.ie

David Matallanas

1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland

Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing

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For correspondence: david.gomez@ucd.ie walter.kolch@ucd.ie

Published 29 August 2022. DOI: 10.26508/lsa.202201445

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MST2 regulates BRAF inhibitors response

David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas

Life Science Alliance Aug 2022, 5 (10) e202201445; DOI: 10.26508/lsa.202201445

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MST2 regulates BRAF inhibitors response

David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas

Life Science Alliance Aug 2022, 5 (10) e202201445; DOI: 10.26508/lsa.202201445

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