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Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

David Romano, View ORCID ProfileLucía García-Gutiérrez, View ORCID ProfileNourhan Aboud, View ORCID ProfileDavid J Duffy, View ORCID ProfileKeith T Flaherty, Dennie T Frederick, View ORCID ProfileWalter Kolch  Correspondence email, View ORCID ProfileDavid Matallanas  Correspondence email
David Romano
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
Roles: Conceptualization, Data curation, Formal analysis, Investigation, Writing—review and editing
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Lucía García-Gutiérrez
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
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  • ORCID record for Lucía García-Gutiérrez
Nourhan Aboud
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
Roles: Investigation
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  • ORCID record for Nourhan Aboud
David J Duffy
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
4Department of Biology/Whitney Laboratory for Marine Bioscience, University of Florida, Gainesville, FL, USA
Roles: Data curation, Investigation, Writing—review and editing
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  • ORCID record for David J Duffy
Keith T Flaherty
3Massachusetts General Hospital, Boston, MA, USA
Roles: Data curation, Investigation, Writing—review and editing
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  • ORCID record for Keith T Flaherty
Dennie T Frederick
3Massachusetts General Hospital, Boston, MA, USA
Roles: Data curation, Investigation, Writing—review and editing
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Walter Kolch
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
2Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Roles: Conceptualization, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing
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  • ORCID record for Walter Kolch
  • For correspondence: david.gomez@ucd.ie walter.kolch@ucd.ie
David Matallanas
1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing
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  • For correspondence: david.gomez@ucd.ie walter.kolch@ucd.ie
Published 29 August 2022. DOI: 10.26508/lsa.202201445
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Article Information

vol. 5 no. 10 e202201445
DOI 
https://doi.org/10.26508/lsa.202201445
PubMed 
36038253

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received March 11, 2022
  • Revision received August 15, 2022
  • Accepted August 19, 2022
  • Published online August 29, 2022.

Copyright & Usage 
© 2022 Romano et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. David Romano1, Conceptualization, Data curation, Formal analysis, Investigation, Writing—review and editing,
  2. Lucía García-Gutiérrez1,
  3. Nourhan Aboud1, Investigation,
  4. David J Duffy1,4, Data curation, Investigation, Writing—review and editing,
  5. Keith T Flaherty3, Data curation, Investigation, Writing—review and editing,
  6. Dennie T Frederick3, Data curation, Investigation, Writing—review and editing,
  7. Walter Kolch1,2⇑, Conceptualization, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing and
  8. David Matallanas1⇑, Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Writing—original draft, review, and editing
  1. 1Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland
  2. 2Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
  3. 3Massachusetts General Hospital, Boston, MA, USA
  4. 4Department of Biology/Whitney Laboratory for Marine Bioscience, University of Florida, Gainesville, FL, USA
  1. Correspondence: david.gomez{at}ucd.ie; walter.kolch{at}ucd.ie
View Full Text

Funding

  • Science Foundation Ireland

    18/SPP/3522; 14/IA/2395
    W Kolch
  • Science Foundation Ireland

    CDA 15_CDA_3495
    D Matallanas
  • UCD’s School of Medicine Ad Astra Fellowship

    N Aboud
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Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma
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MST2 regulates BRAF inhibitors response
David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas
Life Science Alliance Aug 2022, 5 (10) e202201445; DOI: 10.26508/lsa.202201445

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MST2 regulates BRAF inhibitors response
David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas
Life Science Alliance Aug 2022, 5 (10) e202201445; DOI: 10.26508/lsa.202201445
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Volume 5, No. 10
October 2022
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