Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity

Gonzalo Villapalos-García; Pablo Zubiaur; Rebeca Rivas-Durán; Pilar Campos-Norte; Cristina Arévalo-Román; Marta Fernández-Rico; Lucio García-Fraile Fraile; Paula Fernández-Campos; Paula Soria-Chacartegui; Sara Fernández de Córdoba-Oñate; Pablo Delgado-Wicke; Elena Fernández-Ruiz; Isidoro González-Álvaro; Jesús Sanz; Francisco Abad-Santos; Ignacio de los Santos

doi:10.26508/lsa.202201396

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Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity

View ORCID ProfileGonzalo Villapalos-García, View ORCID ProfilePablo Zubiaur Correspondence email, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, View ORCID ProfilePaula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, View ORCID ProfileElena Fernández-Ruiz, View ORCID ProfileIsidoro González-Álvaro, Jesús Sanz, View ORCID ProfileFrancisco Abad-Santos Correspondence email, View ORCID ProfileIgnacio de los Santos Correspondence email

Gonzalo Villapalos-García

1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing—original draft, review, and editing

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Pablo Zubiaur

2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Pablo Zubiaur
For correspondence: pablo.zubiaur@salud.madrid.org

Rebeca Rivas-Durán

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Data curation, Investigation, Writing—review and editing

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Pilar Campos-Norte

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Data curation, Investigation, Writing—review and editing

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Cristina Arévalo-Román

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Data curation, Investigation, Writing—review and editing

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Marta Fernández-Rico

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Data curation, Investigation, Writing—review and editing

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Lucio García-Fraile Fraile

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Conceptualization, Data curation, Visualization, Methodology, Writing—review and editing

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Paula Fernández-Campos

Roles: Investigation, Writing—review and editing

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Paula Soria-Chacartegui

Roles: Investigation, Writing—review and editing

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ORCID record for Paula Soria-Chacartegui

Sara Fernández de Córdoba-Oñate

4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Resources, Writing—review and editing

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Pablo Delgado-Wicke

4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Resources, Writing—review and editing

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Elena Fernández-Ruiz

4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Resources, Writing—review and editing

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Isidoro González-Álvaro

5Rheumatology Service, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Resources, Methodology, Writing—review and editing

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Jesús Sanz

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Resources, Writing—review and editing

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Francisco Abad-Santos

2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing

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ORCID record for Francisco Abad-Santos
For correspondence: francisco.abad@salud.madrid.org

Ignacio de los Santos

3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing

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ORCID record for Ignacio de los Santos
For correspondence: isantosg@salud.madrid.org

Published 30 May 2022. DOI: 10.26508/lsa.202201396

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Comorbidity, sex, and TMPRSS2 rs75603675 on COVID-19 severity

Gonzalo Villapalos-García, Pablo Zubiaur, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, Paula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, Elena Fernández-Ruiz, Isidoro González-Álvaro, Jesús Sanz, Francisco Abad-Santos, Ignacio de los Santos

Life Science Alliance May 2022, 5 (10) e202201396; DOI: 10.26508/lsa.202201396

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Comorbidity, sex, and TMPRSS2 rs75603675 on COVID-19 severity

Life Science Alliance May 2022, 5 (10) e202201396; DOI: 10.26508/lsa.202201396

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Villapalos-García, G., Zubiaur, P., Rivas-Durán, R., Campos-Norte, P., Arévalo-Román, C., Fernández-Rico, M., García-Fraile Fraile, L., Fernández-Campos, P., Soria-Chacartegui, P., Fernández de Córdoba-Oñate, S., Delgado-Wicke, P., Fernández-Ruiz, E., González-Álvaro, I., Sanz, J., Abad-Santos, F., & de los Santos, I. (2022). Correction: Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity and sex are the primary predictors of Covid-19 severity. Life Science Alliance, 5(10), e202201545. Accessed January 15, 2025. https://doi.org/10.26508/lsa.202201545.

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