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Research Article
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Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity

View ORCID ProfileGonzalo Villapalos-García, View ORCID ProfilePablo Zubiaur  Correspondence email, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, View ORCID ProfilePaula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, View ORCID ProfileElena Fernández-Ruiz, View ORCID ProfileIsidoro González-Álvaro, Jesús Sanz, View ORCID ProfileFrancisco Abad-Santos  Correspondence email, View ORCID ProfileIgnacio de los Santos  Correspondence email
Gonzalo Villapalos-García
1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing—original draft, review, and editing
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  • ORCID record for Gonzalo Villapalos-García
Pablo Zubiaur
1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Pablo Zubiaur
  • For correspondence: pablo.zubiaur@salud.madrid.org
Rebeca Rivas-Durán
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Data curation, Investigation, Writing—review and editing
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Pilar Campos-Norte
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Data curation, Investigation, Writing—review and editing
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Cristina Arévalo-Román
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Data curation, Investigation, Writing—review and editing
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Marta Fernández-Rico
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Data curation, Investigation, Writing—review and editing
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Lucio García-Fraile Fraile
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Conceptualization, Data curation, Visualization, Methodology, Writing—review and editing
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Paula Fernández-Campos
1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Investigation, Writing—review and editing
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Paula Soria-Chacartegui
1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Investigation, Writing—review and editing
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  • ORCID record for Paula Soria-Chacartegui
Sara Fernández de Córdoba-Oñate
4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Resources, Writing—review and editing
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Pablo Delgado-Wicke
4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Resources, Writing—review and editing
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Elena Fernández-Ruiz
4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Resources, Writing—review and editing
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Isidoro González-Álvaro
5Rheumatology Service, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Resources, Methodology, Writing—review and editing
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Jesús Sanz
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
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Francisco Abad-Santos
1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing
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  • ORCID record for Francisco Abad-Santos
  • For correspondence: francisco.abad@salud.madrid.org
Ignacio de los Santos
3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing
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  • ORCID record for Ignacio de los Santos
  • For correspondence: isantosg@salud.madrid.org
Published 30 May 2022. DOI: 10.26508/lsa.202201396
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Article Information

vol. 5 no. 10 e202201396
DOI 
https://doi.org/10.26508/lsa.202201396
PubMed 
35636966

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 31, 2022
  • Revision received May 12, 2022
  • Accepted May 13, 2022
  • Published online May 30, 2022.

Copyright & Usage 
© 2022 Villapalos-García et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Gonzalo Villapalos-García, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing—original draft, review, and editing1,*,
  2. Pablo Zubiaur, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing1,2,*⇑,
  3. Rebeca Rivas-Durán, Data curation, Investigation, Writing—review and editing3,
  4. Pilar Campos-Norte, Data curation, Investigation, Writing—review and editing3,
  5. Cristina Arévalo-Román, Data curation, Investigation, Writing—review and editing3,
  6. Marta Fernández-Rico, Data curation, Investigation, Writing—review and editing3,
  7. Lucio García-Fraile Fraile, Conceptualization, Data curation, Visualization, Methodology, Writing—review and editing3,
  8. Paula Fernández-Campos, Investigation, Writing—review and editing1,
  9. Paula Soria-Chacartegui, Investigation, Writing—review and editing1,
  10. Sara Fernández de Córdoba-Oñate, Resources, Writing—review and editing4,
  11. Pablo Delgado-Wicke, Resources, Writing—review and editing4,
  12. Elena Fernández-Ruiz, Resources, Writing—review and editing4,
  13. Isidoro González-Álvaro, Resources, Methodology, Writing—review and editing5,
  14. Jesús Sanz, Resources, Writing—review and editing3,
  15. Francisco Abad-Santos, Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing1,2⇑ and
  16. Ignacio de los Santos, Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Project administration, Writing—review and editing3⇑
  1. 1Clinical Pharmacology Department, Hospital Universitario La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
  2. 2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
  3. 3Infectious Diseases Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
  4. 4Molecular Biology Unit, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
  5. 5Rheumatology Service, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain
  1. Correspondence: pablo.zubiaur{at}salud.madrid.org
  2. francisco.abad{at}salud.madrid.org
  3. isantosg{at}salud.madrid.org
  1. ↵* Gonzalo Villapalos-García and Pablo Zubiaur contributed equally to this work.

View Full Text

Funding

  • Community of Madrid, Banco Santander and CRUE

    Predinmun-COVID
  • Instituto de investigación Carlos III (ISCIII), Spanish Ministry of Science Innovation, and Universities, and the European Regional Development Fund

    PFIS FI20/00090
    G Villapalos-García
  • Infraestructura de Medicina de Precisión asociada a la Ciencia y Tecnología (IMPaCT). Instituto de investigación Carlos III (ISCIII), Spanish Ministry of Science Innovation, and Universities

    IMP/00009
    P Zubiaur
  • Instituto de investigación Carlos III (ISCIII), Spanish Ministry of Science Innovation, and Universities

    PI19/00096
    S Fernández de Córdoba-Oñate, P Delgado-Wicke
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Comorbidity, sex, and TMPRSS2 rs75603675 on COVID-19 severity
Gonzalo Villapalos-García, Pablo Zubiaur, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, Paula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, Elena Fernández-Ruiz, Isidoro González-Álvaro, Jesús Sanz, Francisco Abad-Santos, Ignacio de los Santos
Life Science Alliance May 2022, 5 (10) e202201396; DOI: 10.26508/lsa.202201396

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Comorbidity, sex, and TMPRSS2 rs75603675 on COVID-19 severity
Gonzalo Villapalos-García, Pablo Zubiaur, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, Paula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, Elena Fernández-Ruiz, Isidoro González-Álvaro, Jesús Sanz, Francisco Abad-Santos, Ignacio de los Santos
Life Science Alliance May 2022, 5 (10) e202201396; DOI: 10.26508/lsa.202201396
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Volume 5, No. 10
October 2022
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  • Villapalos-García, G., Zubiaur, P., Rivas-Durán, R., Campos-Norte, P., Arévalo-Román, C., Fernández-Rico, M., García-Fraile Fraile, L., Fernández-Campos, P., Soria-Chacartegui, P., Fernández de Córdoba-Oñate, S., Delgado-Wicke, P., Fernández-Ruiz, E., González-Álvaro, I., Sanz, J., Abad-Santos, F., & de los Santos, I. (2022). Correction: Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity and sex are the primary predictors of Covid-19 severity. Life Science Alliance, 5(10), e202201545. Accessed June 15, 2025. https://doi.org/10.26508/lsa.202201545.

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