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PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

View ORCID ProfileXiaokang Wang, View ORCID ProfileWojciech Rosikiewicz, Yurii Sedkov, View ORCID ProfileTanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, View ORCID ProfileShondra M Pruett-Miller, View ORCID ProfileKristian Helin, View ORCID ProfileHans-Martin Herz  Correspondence email
Xiaokang Wang
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Xiaokang Wang
Wojciech Rosikiewicz
2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing
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  • ORCID record for Wojciech Rosikiewicz
Yurii Sedkov
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology
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Tanner Martinez
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Data curation, Formal analysis, Validation, Investigation, Methodology
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  • ORCID record for Tanner Martinez
Baranda S Hansen
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology
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Patrick Schreiner
2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Data curation, Software, Formal analysis, Validation, Visualization, Methodology
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Jesper Christensen
3Biotech Research and Innovation Centre and The Novo Nordisk Foundation for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark
Roles: Resources
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Beisi Xu
2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Data curation, Software, Formal analysis, Visualization, Methodology
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Shondra M Pruett-Miller
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration
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  • ORCID record for Shondra M Pruett-Miller
Kristian Helin
3Biotech Research and Innovation Centre and The Novo Nordisk Foundation for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark
4Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York City, New York, USA
Roles: Resources, Funding acquisition
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  • ORCID record for Kristian Helin
Hans-Martin Herz
1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing
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  • ORCID record for Hans-Martin Herz
  • For correspondence: hans-martin.herz@stjude.org
Published 19 October 2021. DOI: 10.26508/lsa.202101228
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PROSER1 regulates DNA demethylation
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz
Life Science Alliance Oct 2021, 5 (1) e202101228; DOI: 10.26508/lsa.202101228

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PROSER1 regulates DNA demethylation
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz
Life Science Alliance Oct 2021, 5 (1) e202101228; DOI: 10.26508/lsa.202101228
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Volume 5, No. 1
January 2022
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  • Chromatin & Epigenetics
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