PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

Xiaokang Wang; Wojciech Rosikiewicz; Yurii Sedkov; Tanner Martinez; Baranda S Hansen; Patrick Schreiner; Jesper Christensen; Beisi Xu; Shondra M Pruett-Miller; Kristian Helin; Hans-Martin Herz

doi:10.26508/lsa.202101228

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PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

View ORCID ProfileXiaokang Wang, View ORCID ProfileWojciech Rosikiewicz, Yurii Sedkov, View ORCID ProfileTanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, View ORCID ProfileShondra M Pruett-Miller, View ORCID ProfileKristian Helin, View ORCID ProfileHans-Martin Herz Correspondence email

Xiaokang Wang

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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Wojciech Rosikiewicz

2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing

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ORCID record for Wojciech Rosikiewicz

Yurii Sedkov

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology

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Tanner Martinez

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Data curation, Formal analysis, Validation, Investigation, Methodology

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ORCID record for Tanner Martinez

Baranda S Hansen

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Resources, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology

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Patrick Schreiner

2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Data curation, Software, Formal analysis, Validation, Visualization, Methodology

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Jesper Christensen

3Biotech Research and Innovation Centre and The Novo Nordisk Foundation for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark

Roles: Resources

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Beisi Xu

2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Data curation, Software, Formal analysis, Visualization, Methodology

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Shondra M Pruett-Miller

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration

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Kristian Helin

3Biotech Research and Innovation Centre and The Novo Nordisk Foundation for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark

4Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York City, New York, USA

Roles: Resources, Funding acquisition

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ORCID record for Kristian Helin

Hans-Martin Herz

1Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration, Writing—original draft, review, and editing

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ORCID record for Hans-Martin Herz
For correspondence: hans-martin.herz@stjude.org

Published 19 October 2021. DOI: 10.26508/lsa.202101228

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PROSER1 regulates DNA demethylation

Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz

Life Science Alliance Oct 2021, 5 (1) e202101228; DOI: 10.26508/lsa.202101228

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PROSER1 regulates DNA demethylation

Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz

Life Science Alliance Oct 2021, 5 (1) e202101228; DOI: 10.26508/lsa.202101228

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PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

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