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Table of Contents

January 2022 | Volume 5, No. 1

Research Articles

  • Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins
    Open Access
    Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins

    Yuta Endo, Yuko Shimizu, Hanako Nishikawa, Katsuhiro Sawasato, Ken-ichi Nishiyama

    Yuta Endo ... Ken-ichi Nishiyama

    Published 12 October 2021

    Charges in the N-terminal region and the synthesis level of membrane proteins with N-out topology determine YidC and PMF dependencies with the interplay between glycolipid MPIase, YidC, and PMF.

  • Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
    Open Access
    Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

    Jacqueline V Graniel, Kamlesh Bisht, Ann Friedman, James White, Eric Perkey, Ashley Vanderbeck, Alina Moroz, Léolène J Carrington, Joshua D Brandstadter, Frederick Allen, Adrienne Niederriter Shami, Peedikayil Thomas, Aniela Crayton, Mariel Manzor, Anna Mychalowych, Jennifer Chase, Saher S Hammoud, Catherine E Keegan, Ivan Maillard, Jayakrishnan Nandakumar

    Jacqueline V Graniel ... Jayakrishnan Nandakumar

    Published 13 October 2021

    A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.

  • HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7
    Open Access
    HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7

    Fu-Kai Hsieh, Fei Ji, Manashree Damle, Ruslan I Sadreyev, Robert E Kingston

    Fu-Kai Hsieh ... Robert E Kingston

    Published 18 October 2021

    Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.

  • PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands
    Open Access
    PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

    Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz

    Xiaokang Wang ... Hans-Martin Herz

    Published 19 October 2021

    PROSER1 promotes the interaction between TET2 and the glycosyltransferase OGT to regulate TET2 O-GlcNAcylation and stability on genomic elements that depend on the activity of the MLL3/4 complexes.

  • Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration
    Open Access
    Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration

    Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda

    Shuhao Lin ... Michiyuki Matsuda

    Published 19 October 2021

    By knocking out all four EGFR ligands expressed in MDCK cells, this study shows the redundant and specific roles of each EGFR ligand in the ERK activation waves during collective cell migration.

  • KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo
    Open Access
    KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo

    Stephen B Waters, Joseph R Dominguez, Hyun-Dong Cho, Nicolene A Sarich, Asrar B Malik, Kaori H Yamada

    Stephen B Waters ... Kaori H Yamada

    Published 20 October 2021

    The cancer cells secrete VEGF, which induces vascular leakage and metastasis. Inhibition of VEGFR2 trafficking to the cell surface prevents receiving VEGF, vascular leakage, and cancer metastasis.

  • Single-domain antibody screening by <em>is</em>PLA-seq
    Open Access
    Single-domain antibody screening by isPLA-seq

    Yueyuan Yin, Fei Yan, Ruimin Zhou, Mingchen Li, Jinyi Ma, Zhe Liu, Zhenyi Ma

    Yueyuan Yin ... Zhenyi Ma

    Published 21 October 2021

    This study describes a high-sensitive, high-throughput single-domain antibody library screening approach, which is applicable for any given interested protein at single-cell resolution by isPLA-seq.

  • Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
    Open Access
    Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia

    Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa

    Yoko Miura ... Satoshi Kanazawa

    Published 2 November 2021

    A novel mouse model of induced-usual interstitial pneumonia shows bimodal fibrosis with honeycombing, similar to chronic lung disease seen with idiopathic pulmonary fibrosis.

  • Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation
    Open Access
    Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation

    Qi Chen, Sajith Nair, Christiane Ruedl

    Qi Chen ... Christiane Ruedl

    Published 2 November 2021

    Maintenance of the gut lamina propria–resident macrophage cell pool requires monocyte input during adulthood. Here, Ruedl and colleagues demonstrate that the intestinal microbiome positively influences the replenishment of tissue-resident macrophages under both steady-state and inflammatory conditions.

  • Structure of <em>Aedes aegypti</em> procarboxypeptidase B1 and its binding with Dengue virus for controlling infection
    Open Access
    Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

    Edem Gavor, Yeu Khai Choong, Nikhil Kumar Tulsian, Digant Nayak, Fakhriedzwan Idris, Hariharan Sivaraman, Donald Heng Rong Ting, Alonso Sylvie, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

    Edem Gavor ... J Sivaraman

    Published 8 November 2021

    Using high-resolution structure, we have characterized the substrate specificity of Aedes aegypti procarboxypeptidase B1 and provided mechanistic insights into the binding and inhibition of DENV

  • Structural basis of membrane recognition of <em>Toxoplasma gondii</em> vacuole by Irgb6
    Open Access
    Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6

    Yumiko Saijo-Hamano, Aalaa Alrahman Sherif, Ariel Pradipta, Miwa Sasai, Naoki Sakai, Yoshiaki Sakihama, Masahiro Yamamoto, Daron M Standley, Ryo Nitta

    Yumiko Saijo-Hamano ... Ryo Nitta

    Published 9 November 2021

    Upon Toxoplasma gondii infection, Irgb6 is recruited to the parasitophorous vacuole membrane (PVM) where Irgb6 disrupts it. We solved the atomic structures of Irgb6 in two distinct nucleotide states, revealing a unique PVM-binding interface sensitive to GTPase cycling.

  • Molecular and genetic dissection of recursive splicing
    Open Access
    Molecular and genetic dissection of recursive splicing

    Brian Joseph, Chaz Scala, Shu Kondo, Eric C Lai

    Brian Joseph ... Eric C Lai

    Published 10 November 2021

    Recursive splicing is an unusual form of stepwise mRNA processing involving exons with functional splice donors at their 5′ ends. We use molecular and genetic assays to show three parameters that influence mRNA isoform outcomes during recursive splicing in Drosophila.

  • Integrated stress response restricts macrophage necroptosis
    Open Access
    Integrated stress response restricts macrophage necroptosis

    David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti

    David E Place ... Thirumala-Devi Kanneganti

    Published 11 November 2021

    Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.

Resources

  • Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
    Open Access
    Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology

    Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely

    Einat B Vitner ... Tomer Israely

    Published 11 November 2021

    SARS-CoV-2 infection alters the levels of sphingolipids early post infection. This phenomenon is reflected by increased levels of sphingolipids, including gangliosides, in infected cells, as well as in serum in a SARS-CoV-2 murine model.

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Volume 5, No. 1
January 2022
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