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Research Article
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A serum proteome signature to predict mortality in severe COVID-19 patients

Franziska Völlmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, Ottavio Zucchetti, Alberto Papi, Carlo Alberto Volta, Luisa Marracino, Francesco Vieceli Dalla Sega, Francesca Fortini, Vadim Demichev, View ORCID ProfilePinkus Tober-Lau, Gianluca Campo, Marco Contoli, Markus Ralser, Florian Kurth, View ORCID ProfileSavino Spadaro, Paola Rizzo, View ORCID ProfileAlbert JR Heck  Correspondence email
Franziska Völlmy
1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
2Netherlands Proteomics Center, Utrecht, The Netherlands
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Henk van den Toorn
1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
2Netherlands Proteomics Center, Utrecht, The Netherlands
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Riccardo Zenezini Chiozzi
1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
2Netherlands Proteomics Center, Utrecht, The Netherlands
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Ottavio Zucchetti
3Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy
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Alberto Papi
4Respiratory Section, Department of Translational Medicine, University of Ferrara, Ferrara, Italy and Respiratory Disease Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy
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Carlo Alberto Volta
5Department of Translational Medicine University of Ferrara, Ferrara, Italy and Intensive Care Unit, Azienda Ospedaliero-Universitaria di Ferrara, Italy
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Luisa Marracino
6Department of Translational Medicine and Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
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Francesco Vieceli Dalla Sega
7Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
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Francesca Fortini
7Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
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Vadim Demichev
8Charité–Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany
9The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK
10The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge, UK
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Pinkus Tober-Lau
11Charité–Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany
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  • ORCID record for Pinkus Tober-Lau
Gianluca Campo
3Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy
7Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
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Marco Contoli
4Respiratory Section, Department of Translational Medicine, University of Ferrara, Ferrara, Italy and Respiratory Disease Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy
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Markus Ralser
8Charité–Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany
9The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK
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Florian Kurth
11Charité–Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany
12National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Savino Spadaro
5Department of Translational Medicine University of Ferrara, Ferrara, Italy and Intensive Care Unit, Azienda Ospedaliero-Universitaria di Ferrara, Italy
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Paola Rizzo
6Department of Translational Medicine and Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
7Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
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Albert JR Heck
1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
2Netherlands Proteomics Center, Utrecht, The Netherlands
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  • ORCID record for Albert JR Heck
  • For correspondence: a.j.r.heck@uu.nl
Published 5 July 2021. DOI: 10.26508/lsa.202101099
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Article Information

vol. 4 no. 9 e202101099
DOI 
https://doi.org/10.26508/lsa.202101099
PubMed 
34226277

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received April 16, 2021
  • Revision received June 24, 2021
  • Accepted June 24, 2021
  • Published online July 5, 2021.

Copyright & Usage 
© 2021 Völlmy et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Franziska Völlmy1,2,
  2. Henk van den Toorn1,2,
  3. Riccardo Zenezini Chiozzi1,2,
  4. Ottavio Zucchetti3,
  5. Alberto Papi4,
  6. Carlo Alberto Volta5,
  7. Luisa Marracino6,
  8. Francesco Vieceli Dalla Sega7,
  9. Francesca Fortini7,
  10. Vadim Demichev8,9,10,
  11. Pinkus Tober-Lau11,
  12. Gianluca Campo3,7,
  13. Marco Contoli4,
  14. Markus Ralser8,9,
  15. Florian Kurth11,12,
  16. Savino Spadaro5,
  17. Paola Rizzo6,7 and
  18. Albert JR Heck1,2⇑
  1. 1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
  2. 2Netherlands Proteomics Center, Utrecht, The Netherlands
  3. 3Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy
  4. 4Respiratory Section, Department of Translational Medicine, University of Ferrara, Ferrara, Italy and Respiratory Disease Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy
  5. 5Department of Translational Medicine University of Ferrara, Ferrara, Italy and Intensive Care Unit, Azienda Ospedaliero-Universitaria di Ferrara, Italy
  6. 6Department of Translational Medicine and Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy
  7. 7Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
  8. 8Charité–Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany
  9. 9The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK
  10. 10The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge, UK
  11. 11Charité–Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany
  12. 12National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
  1. Correspondence: a.j.r.heck{at}uu.nl
View Full Text

Funding

  • The Netherlands Proteomics Centre through the X-omics Road Map program

    184.034.019
  • EU Horizon 2020 program INFRAIA project Epic-XS

    Project 823839
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A proteome signature predicting COVID-19 mortality
Franziska Völlmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, Ottavio Zucchetti, Alberto Papi, Carlo Alberto Volta, Luisa Marracino, Francesco Vieceli Dalla Sega, Francesca Fortini, Vadim Demichev, Pinkus Tober-Lau, Gianluca Campo, Marco Contoli, Markus Ralser, Florian Kurth, Savino Spadaro, Paola Rizzo, Albert JR Heck
Life Science Alliance Jul 2021, 4 (9) e202101099; DOI: 10.26508/lsa.202101099

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A proteome signature predicting COVID-19 mortality
Franziska Völlmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, Ottavio Zucchetti, Alberto Papi, Carlo Alberto Volta, Luisa Marracino, Francesco Vieceli Dalla Sega, Francesca Fortini, Vadim Demichev, Pinkus Tober-Lau, Gianluca Campo, Marco Contoli, Markus Ralser, Florian Kurth, Savino Spadaro, Paola Rizzo, Albert JR Heck
Life Science Alliance Jul 2021, 4 (9) e202101099; DOI: 10.26508/lsa.202101099
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Volume 4, No. 9
September 2021
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